WormBase Tree Display for Gene: WBGene00000157
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| WBGene00000157 | SMap | S_parent | Sequence | F02E8 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | aps-2 | Person_evidence | WBPerson360 | |||||
| Sequence_name | F02E8.3 | ||||||||
| Molecular_name | F02E8.3 | ||||||||
| F02E8.3.1 | |||||||||
| CE07018 | |||||||||
| Other_name | CELE_F02E8.3 | Accession_evidence | NDB | BX284606 | |||||
| Public_name | aps-2 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:20 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | aps | ||||||||
| Allele (17) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (13) | |||||||||
| Ortholog (36) | |||||||||
| Paralog | WBGene00000159 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| WBGene00000165 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | aps-2 encodes an adaptin: specifically, it encodes an ortholog of the sigma2 subunit of adaptor protein complex 2 (AP2), which mediates endocytosis from the plasma membrane; APS-2 is required for embryonic and larval development and for normal body morphogenesis, but is not required for endocytosis of yolk protein in developing oocytes; APS-2 is expressed in nearly all cells during embryogenesis, but during larval and adult stages, expression is confined to neurons and some hypodermal cells, including vulval hypodermal cells during the fourth larval stage. | Paper_evidence | WBPaper00003831 | |||||
| WBPaper00004187 | |||||||||
| WBPaper00004907 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 21 Mar 2008 00:00:00 | ||||||||
| Automated_description | Predicted to enable clathrin binding activity. Involved in several processes, including body morphogenesis; clathrin-dependent endocytosis; and nematode larval development. Predicted to be located in intracellular membrane-bounded organelle. Expressed in neurons. Human ortholog(s) of this gene implicated in familial hypocalciuric hypercalcemia 3. Is an ortholog of human AP2S1 (adaptor related protein complex 2 subunit sigma 1). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0060702 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:565) | ||||
| Molecular_info | Corresponding_CDS | F02E8.3 | |||||||
| Corresponding_transcript | F02E8.3.1 | ||||||||
| Other_sequence (34) | |||||||||
| Associated_feature | WBsf648013 | ||||||||
| WBsf662688 | |||||||||
| WBsf1004950 | |||||||||
| WBsf1022787 | |||||||||
| WBsf235578 | |||||||||
| WBsf235579 | |||||||||
| Experimental_info | RNAi_result (16) | ||||||||
| Expr_pattern | Expr1131 | ||||||||
| Expr3602 | |||||||||
| Expr1027362 | |||||||||
| Expr1030086 | |||||||||
| Expr1147796 | |||||||||
| Expr2009367 | |||||||||
| Expr2027603 | |||||||||
| Drives_construct | WBCnstr00006657 | ||||||||
| WBCnstr00010097 | |||||||||
| WBCnstr00017687 | |||||||||
| WBCnstr00037697 | |||||||||
| Construct_product | WBCnstr00006657 | ||||||||
| WBCnstr00011527 | |||||||||
| WBCnstr00017687 | |||||||||
| WBCnstr00037697 | |||||||||
| Microarray_results (20) | |||||||||
| Expression_cluster (130) | |||||||||
| Interaction (54) | |||||||||
| Map_info | Map | X | Position | -7.59862 | Error | 0.010695 | |||
| Positive | Positive_clone | F02E8 | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Pseudo_map_position | |||||||||
| Reference | WBPaper00003831 | ||||||||
| WBPaper00004187 | |||||||||
| WBPaper00004907 | |||||||||
| WBPaper00032011 | |||||||||
| WBPaper00038491 | |||||||||
| WBPaper00041806 | |||||||||
| WBPaper00051874 | |||||||||
| WBPaper00055090 | |||||||||
| Remark | Sequence connection from [Shim J, Lee J] | ||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
