WormBase Tree Display for Gene: WBGene00000201
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| WBGene00000201 | Evidence | Paper_evidence | WBPaper00005843 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | Y79H2A | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | arx-3 | Person_evidence | WBPerson633 | |||||
| Sequence_name | Y79H2A.6 | ||||||||
| Molecular_name | Y79H2A.6a | ||||||||
| Y79H2A.6a.1 | |||||||||
| CE24672 | |||||||||
| Y79H2A.6b | |||||||||
| CE52951 | |||||||||
| Y79H2A.6b.1 | |||||||||
| Other_name | CELE_Y79H2A.6 | Accession_evidence | NDB | BX284603 | |||||
| Public_name | arx-3 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:20 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | arx | ||||||||
| Allele (150) | |||||||||
| Strain | WBStrain00037704 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (13) | |||||||||
| Contained_in_operon | CEOP3750 | ||||||||
| Ortholog (46) | |||||||||
| Structured_description | Concise_description | arx-3 also called as p41Arc encodes a subunit of the actin related protein of the conserved Arp2/3 complex, with 60% amino acid similarity with the homologous genes from human (OMIM: 604223); arx-3 is an essential gene as disruption in the expression by RNAi results in embryonic arrest due to ventral enclosure during morphogenesis; Arp2/3 depletion results in partial shrinking of the Ea/p apical surfaces and incomplete Ea/p cell internalization; WSP-1 activates Arp2/3 complex in vitro; WSP-1 and the Arp2/3 complex associate and function cell autonomously at cell boundaries during ventral enclosure; localization of WSP-1 is dependent on the Arp2/3 complex; expression of WSP-1 increases by the reduction of functional ARX-1. Arp2/3 regulates some Apical Junction components in embryos and adults; Arp2/3 is required during intestinal morphogenesis for regulation of intestinal lumen width in embryos and apical F-actin accumulation during larval and adult growth. | Paper_evidence | WBPaper00005843 | |||||
| WBPaper00035433 | |||||||||
| WBPaper00039779 | |||||||||
| Curator_confirmed | WBPerson12884 | ||||||||
| WBPerson1843 | |||||||||
| Date_last_updated | 10 Aug 2011 00:00:00 | ||||||||
| Automated_description | Predicted to enable actin filament binding activity. Predicted to be involved in Arp2/3 complex-mediated actin nucleation. Predicted to be located in actin cytoskeleton and cytoplasm. Predicted to be part of Arp2/3 protein complex. Human ortholog(s) of this gene implicated in several diseases, including gastrointestinal system cancer (multiple); immunodeficiency 71; and myelodysplastic syndrome. Is an ortholog of human ARPC1A (actin related protein 2/3 complex subunit 1A) and ARPC1B (actin related protein 2/3 complex subunit 1B). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0050866 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:704) | ||||
| DOID:4029 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:704) | ||||||
| DOID:0112004 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:704) | ||||||
| DOID:0050908 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:704) | ||||||
| DOID:1793 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:703) | ||||||
| DOID:10534 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:704) | ||||||
| DOID:5419 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:703,HGNC:704) | ||||||
| Molecular_info | Corresponding_CDS | Y79H2A.6a | |||||||
| Y79H2A.6b | |||||||||
| Corresponding_transcript | Y79H2A.6a.1 | ||||||||
| Y79H2A.6b.1 | |||||||||
| Other_sequence (57) | |||||||||
| Associated_feature | WBsf651527 | ||||||||
| WBsf667492 | |||||||||
| WBsf667493 | |||||||||
| WBsf994562 | |||||||||
| WBsf1016134 | |||||||||
| WBsf227627 | |||||||||
| WBsf227628 | |||||||||
| WBsf227629 | |||||||||
| WBsf227630 | |||||||||
| Experimental_info | RNAi_result (40) | ||||||||
| Expr_pattern | Expr3600 | ||||||||
| Expr1013871 | |||||||||
| Expr1030120 | |||||||||
| Expr1161935 | |||||||||
| Expr2009436 | |||||||||
| Expr2027673 | |||||||||
| Construct_product | WBCnstr00011525 | ||||||||
| WBCnstr00019216 | |||||||||
| Microarray_results (18) | |||||||||
| Expression_cluster (93) | |||||||||
| Interaction (89) | |||||||||
| Map_info | Map | III | Position | 14.3021 | Error | 0.175498 | |||
| Positive | Positive_clone | Y79H2A | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Mapping_data | Multi_point | 4904 | |||||||
| 5038 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (11) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
