WormBase Tree Display for Gene: WBGene00000226
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| WBGene00000226 | Evidence | CGC_data_submission | |||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | T06E4 | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | atl-1 | Person_evidence | WBPerson1551 | |||||
| Sequence_name | T06E4.3 | ||||||||
| Molecular_name | T06E4.3a | ||||||||
| T06E4.3a.1 | |||||||||
| CE25103 | |||||||||
| T06E4.3c | |||||||||
| CE45629 | |||||||||
| T06E4.3a.2 | |||||||||
| T06E4.3c.1 | |||||||||
| Other_name | Ce-atl1 | Accession_evidence | EMBL | AB018598 | |||||
| CELE_T06E4.3 | Accession_evidence | NDB | BX284605 | ||||||
| Public_name | atl-1 | ||||||||
| DB_info | Database (15) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:20 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | atl | ||||||||
| Allele (123) | |||||||||
| Strain | WBStrain00036017 | ||||||||
| WBStrain00006438 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (25) | |||||||||
| Contained_in_operon | CEOP5585 | ||||||||
| Ortholog (43) | |||||||||
| Paralog | WBGene00004879 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| WBGene00000227 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00002583 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00007028 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | The atl-1 gene encodes a large, 2514-residue protein of the ATM family, homologous to human AT (OMIM:208900, mutated in ataxia telangiectasia); the C-terminal sequence of ATL-1 contains a PI-3 kinase-like domain; ATL-1 is required for survival through early embryogenesis and normal chromosomal segregation; atl-1 is expressed in both the mitotic and meiotic cells of adult gonads. | Paper_evidence | WBPaper00004326 | |||||
| Curator_confirmed | WBPerson567 | ||||||||
| Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
| Automated_description | Predicted to enable 1-phosphatidylinositol-3-kinase activity and protein serine/threonine kinase activity. Involved in DNA damage checkpoint signaling; embryo development; and meiotic chromosome segregation. Located in nucleus. Expressed in gonad. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; Seckel syndrome 1; gastrointestinal system cancer (multiple); and pancreatic cancer. Is an ortholog of human ATR (ATR serine/threonine kinase). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:10652 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:882) | ||||
| DOID:9261 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:882) | ||||||
| DOID:0070007 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:882) | ||||||
| DOID:1324 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:882) | ||||||
| DOID:1793 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:882) | ||||||
| DOID:219 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:882) | ||||||
| DOID:0080202 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:882) | ||||||
| Molecular_info | Corresponding_CDS | T06E4.3a | |||||||
| T06E4.3c | |||||||||
| Corresponding_CDS_history | T06E4.3:wp52 | ||||||||
| T06E4.3b:wp270 | |||||||||
| Corresponding_transcript | T06E4.3a.1 | ||||||||
| T06E4.3a.2 | |||||||||
| T06E4.3c.1 | |||||||||
| Other_sequence | AB018598 | ||||||||
| SRC07073_1 | |||||||||
| FC813984.1 | |||||||||
| FG976670.1 | |||||||||
| Associated_feature | WBsf652930 | ||||||||
| WBsf669247 | |||||||||
| WBsf234255 | |||||||||
| Experimental_info | RNAi_result (23) | ||||||||
| Expr_pattern | Expr1119 | ||||||||
| Expr1120 | |||||||||
| Expr4273 | |||||||||
| Expr11800 | |||||||||
| Expr1019215 | |||||||||
| Expr1030143 | |||||||||
| Expr1156260 | |||||||||
| Expr2009505 | |||||||||
| Expr2027742 | |||||||||
| Drives_construct | WBCnstr00037648 | ||||||||
| Construct_product | WBCnstr00037648 | ||||||||
| Antibody | WBAntibody00001035 | ||||||||
| WBAntibody00001157 | |||||||||
| Microarray_results (29) | |||||||||
| Expression_cluster (132) | |||||||||
| Interaction (114) | |||||||||
| Map_info | Map | V | Position | 2.06022 | Error | 0.000681 | |||
| Positive | Positive_clone | T06E4 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference (70) | |||||||||
| Remark | Sequence connection from [Boulton S, Vidal M] | ||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
