WormBase Tree Display for Gene: WBGene00000257
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| WBGene00000257 | SMap | S_parent | Sequence | CHROMOSOME_V | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | bmk-1 | Person_evidence | WBPerson565 | |||||
| Sequence_name | F23B12.8 | ||||||||
| Molecular_name | F23B12.8a | ||||||||
| F23B12.8a.1 | |||||||||
| CE09600 | |||||||||
| F23B12.8b | |||||||||
| CE45384 | |||||||||
| F23B12.8b.1 | |||||||||
| Other_name | klp-14 | ||||||||
| CELE_F23B12.8 | Accession_evidence | NDB | BX284605 | ||||||
| Public_name | bmk-1 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:20 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | bmk | ||||||||
| Allele (70) | |||||||||
| Strain | WBStrain00031533 | ||||||||
| WBStrain00034607 | |||||||||
| WBStrain00034610 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (23) | |||||||||
| Ortholog (43) | |||||||||
| Paralog (19) | |||||||||
| Structured_description | Concise_description | bmk-1 encodes the sole C. elegans BimC/kinesin-5 homolog; while BMK-1 activity is not essential for mitotic progression or development, BMK-1 does play a role in negatively regulating interpolar microtubule sliding during anaphase spindle elongation, thus serving as a brake to slow the rate of spindle-pole separation; BMK-1 localizes to mitotic and meiotic spindles and becomes concentrated at the spindle midzone during mitotic anaphase and telophase; in vivo, BMK-1 localization is dependent upon the AIR-2/Aurora B kinase with which it interacts and serves as a substrate in vitro. | Paper_evidence | WBPaper00024605 | |||||
| WBPaper00030799 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson480 | |||||||||
| Date_last_updated | 23 Jul 2007 00:00:00 | ||||||||
| Automated_description | Predicted to enable plus-end-directed microtubule motor activity. Involved in negative regulation of mitotic spindle elongation. Located in spindle midzone and spindle pole. Human ortholog(s) of this gene implicated in microcephaly with or without chorioretinopathy, lymphedema, or mental retardation. Is an ortholog of human KIF11 (kinesin family member 11). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0060349 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6388) | ||||
| Molecular_info | Corresponding_CDS | F23B12.8a | |||||||
| F23B12.8b | |||||||||
| Corresponding_transcript | F23B12.8a.1 | ||||||||
| F23B12.8b.1 | |||||||||
| Other_sequence | AF295093 | ||||||||
| CBC12983_1 | |||||||||
| HBC01778_1 | |||||||||
| JI171620.1 | |||||||||
| EG025511.1 | |||||||||
| BXC02175_1 | |||||||||
| ES742822.1 | |||||||||
| JI257369.1 | |||||||||
| CJC16998_1 | |||||||||
| Tcol_isotig16017 | |||||||||
| Associated_feature | WBsf653388 | ||||||||
| WBsf653389 | |||||||||
| WBsf234952 | |||||||||
| WBsf234953 | |||||||||
| Experimental_info | RNAi_result (14) | ||||||||
| Expr_pattern | Expr4769 | ||||||||
| Expr4770 | |||||||||
| Expr1014302 | |||||||||
| Expr1030166 | |||||||||
| Expr1149307 | |||||||||
| Expr2009640 | |||||||||
| Expr2027879 | |||||||||
| Drives_construct | WBCnstr00037623 | ||||||||
| Construct_product | WBCnstr00037623 | ||||||||
| Antibody | WBAntibody00001003 | ||||||||
| Microarray_results (22) | |||||||||
| Expression_cluster (189) | |||||||||
| Interaction (75) | |||||||||
| Map_info | Map | V | Position | 6.38237 | Error | 0.013317 | |||
| Positive | Positive_clone | F23B12 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 4170 | |||||||
| 4233 | |||||||||
| 5296 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (23) | |||||||||
| Remark | Sequence connection from [source J Schumacher] | ||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
