WormBase Tree Display for Gene: WBGene00000298

WBGene00000298 SMap: S_parent: Sequence: CHROMOSOME_V
  Identity: Version: 1
    Name: CGC_name: cat-4 Person_evidence: WBPerson261
      Sequence_name: F32G8.6
      Molecular_name: F32G8.6
        F32G8.6.1
        CE05795
      Other_name: gtpch-1 Paper_evidence: WBPaper00005354
        CELE_F32G8.6 Accession_evidence: NDB BX284605
      Public_name: cat-4
    DB_info: Database (13)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:20 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: cat
    Reference_allele: WBVar00143773
    Allele (28)
    Legacy_information: e1141 : dopamine reduced > 90%. ES1 ME2 NA1.
      [Leon Avery] Serotonin is reduced or absent (CGC#1105).
      See also e1141
      [C.elegansII] e1141 : dopamine reduced > 90%, serotonin reduced orabsent; poor male turning behavior; enhanced foraging behavior, suppressed by serotonin agonists; serotonin immunoreactivity restored by exogenous serotonin or 5-hydroxytryptophan;cuticle defective, hypersensitive to SDS, levamisole,hypochlorite.. ES1 ME2 NA1. [Sulston et al. 1975; Loer and Kenyon 1993; DA; KP; LC]
    Strain: WBStrain00024111
      WBStrain00024121
      WBStrain00027351
      WBStrain00004253
      WBStrain00004816
      WBStrain00024116
    RNASeq_FPKM (74)
    GO_annotation (27)
    Ortholog (39)
    Structured_description: Automated_description: Enables GTP cyclohydrolase I activity. Involved in dopamine biosynthetic process from tyrosine; melanin biosynthetic process; and tetrahydrobiopterin biosynthetic process. Predicted to be located in cytoplasm. Expressed in several structures, including body wall musculature; dopaminergic neurons; hyp7 syncytium; intestinal cell; and serotonergic neurons. Human ortholog(s) of this gene implicated in several diseases, including BH4-deficient hyperphenylalaninemia B; diabetic angiopathy; and movement disease (multiple). Is an ortholog of human GCH1 (GTP cyclohydrolase 1). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model (11)
  Molecular_info: Corresponding_CDS: F32G8.6
    Corresponding_transcript: F32G8.6.1
    Other_sequence (413)
    Associated_feature: WBsf047518
      WBsf047519
      WBsf047520
      WBsf1001139
      WBsf1020318
      WBsf232395
  Experimental_info: RNAi_result: WBRNAi00031695 Inferred_automatically: RNAi_primary
      WBRNAi00115602 Inferred_automatically: RNAi_primary
      WBRNAi00014232 Inferred_automatically: RNAi_primary
      WBRNAi00115714 Inferred_automatically: RNAi_primary
      WBRNAi00046157 Inferred_automatically: RNAi_primary
      WBRNAi00115603 Inferred_automatically: RNAi_primary
      WBRNAi00115701 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr4817
      Expr12165
      Expr1027591
      Expr1150045
      Expr2009728
      Expr2027967
    Drives_construct: WBCnstr00012257
      WBCnstr00015879
      WBCnstr00017075
      WBCnstr00020335
      WBCnstr00037596
    Construct_product: WBCnstr00012257
      WBCnstr00037596
    Microarray_results (19)
    Expression_cluster (261)
    Interaction (175)
  Map_info: Map: V Position: 2.59941 Error: 0.001738
    Positive: Positive_clone: F32G8 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 151
        1529
        2269
      Pos_neg_data: 6765
        6766
        6767
        6769
        6771
  Reference: WBPaper00000365
    WBPaper00000480
    WBPaper00000527
    WBPaper00000608
    WBPaper00001105
    WBPaper00001285
    WBPaper00001689
    WBPaper00001704
    WBPaper00001854
    WBPaper00001861
    WBPaper00002320
    WBPaper00003655
    WBPaper00003951
    WBPaper00004195
    WBPaper00004257
    WBPaper00004653
    WBPaper00005274
    WBPaper00005469
    WBPaper00005511
    WBPaper00005551
    WBPaper00005734
    WBPaper00006103
    WBPaper00010979
    WBPaper00011634
    WBPaper00011911
    WBPaper00013858
    WBPaper00014504
    WBPaper00014653
    WBPaper00014717
    WBPaper00015375
    WBPaper00016741
    WBPaper00017250
    WBPaper00017338
    WBPaper00017417
    WBPaper00017477
    WBPaper00017787
    WBPaper00017992
    WBPaper00018297
    WBPaper00019156
    WBPaper00019250
    WBPaper00021914
    WBPaper00022172
    WBPaper00022173
    WBPaper00022889
    WBPaper00023396
    WBPaper00023549
    WBPaper00023572
    WBPaper00024949
    WBPaper00025146
    WBPaper00026622
    WBPaper00026818
    WBPaper00026835
    WBPaper00026948
    WBPaper00027669
    WBPaper00029013
    WBPaper00029029
    WBPaper00029060
    WBPaper00030285
    WBPaper00030761
    WBPaper00030941
    WBPaper00030989
    WBPaper00031366
    WBPaper00031861
    WBPaper00031936
    WBPaper00032335
    WBPaper00032638
    WBPaper00032994
    WBPaper00033705
    WBPaper00034171
    WBPaper00034518
    WBPaper00037498
    WBPaper00037844
    WBPaper00038491
    WBPaper00041493
    WBPaper00041560
    WBPaper00042470
    WBPaper00043610
    WBPaper00043908
    WBPaper00044457
    WBPaper00046585
    WBPaper00047935
    WBPaper00052649
    WBPaper00052716
    WBPaper00053165
    WBPaper00055090
    WBPaper00055798
    WBPaper00059947
    WBPaper00060921
    WBPaper00061476
    WBPaper00061641
    WBPaper00065325
    WBPaper00065331
    WBPaper00066019
    WBPaper00066057
  Remark: Interacting_genes '[Leon Avery] unc-31: cat-4 enhances the Egl defect of unc-31 mutants, especially at 15C.
  Method: Gene