WormBase Tree Display for Gene: WBGene00000372
expand all nodes | collapse all nodes | view schema
| WBGene00000372 | Evidence | Person_evidence | WBPerson427 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Author_evidence | Gilchrist EJ | ||||||||
| SMap | S_parent | Sequence | T10B9 | ||||||
| Identity | Version | 2 | |||||||
| Name | CGC_name | cyp-13A7 | |||||||
| Sequence_name | T10B9.10 | ||||||||
| Molecular_name | T10B9.10 | ||||||||
| T10B9.10.1 | |||||||||
| CE01655 | |||||||||
| Other_name | ccp-13A7 | CGC_data_submission | |||||||
| CELE_T10B9.10 | Accession_evidence | NDB | BX284602 | ||||||
| Public_name | cyp-13A7 | ||||||||
| DB_info | Database (13) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:20 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| 2 | 21 Sep 2004 09:38:16 | WBPerson1971 | Name_change | CGC_name | ccp-13A7 -> cyp-13A7 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | cyp | ||||||||
| Allele (34) | |||||||||
| Strain | WBStrain00035499 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation | 00079962 | ||||||||
| 00079963 | |||||||||
| 00079964 | |||||||||
| 00107249 | |||||||||
| 00107250 | |||||||||
| 00107251 | |||||||||
| 00107252 | |||||||||
| Ortholog (68) | |||||||||
| Paralog (12) | |||||||||
| Structured_description | Concise_description | cyp-13A7 encodes a homolog of cytochrome P450 proteins; these proteins are membrane proteins with a heme prosthetic group that catalyze the synthesis of steroid hormones (and bile salts), and also detoxify foreign substances (xenobiotic compounds); loss of cyp-13A7 activity in large-scale RNAi screens results in uncoordinated locomotion and decreased and/or slow growth; a cyp-13A7::gfp promoter fusion is induced in the intestine in response to treatment with the antibiotic rifampicin. | Paper_evidence | WBPaper00005654 | |||||
| WBPaper00006395 | |||||||||
| WBPaper00013148 | |||||||||
| WBPaper00031939 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 20 Nov 2008 00:00:00 | ||||||||
| Automated_description | Predicted to enable heme binding activity; iron ion binding activity; and oxidoreductase activity. Expressed in intestine. Human ortholog(s) of this gene implicated in several diseases, including Ghosal hematodiaphyseal syndrome; familial Mediterranean fever; and leukemia (multiple). Is an ortholog of several human genes including CYP3A4 (cytochrome P450 family 3 subfamily A member 4); CYP3A5 (cytochrome P450 family 3 subfamily A member 5); and CYP3A7 (cytochrome P450 family 3 subfamily A member 7). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:8552 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2638) | ||||
| DOID:3526 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11609) | ||||||
| DOID:2987 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2637) | ||||||
| DOID:9952 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2638) | ||||||
| DOID:0112251 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11609) | ||||||
| DOID:0080630 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2638) | ||||||
| DOID:10825 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2638) | ||||||
| DOID:1612 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2637) | ||||||
| Molecular_info | Corresponding_CDS | T10B9.10 | |||||||
| Corresponding_transcript | T10B9.10.1 | ||||||||
| Associated_feature | WBsf221933 | ||||||||
| Experimental_info | RNAi_result | WBRNAi00035420 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00053014 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00092625 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr8187 | ||||||||
| Expr1011535 | |||||||||
| Expr1156614 | |||||||||
| Expr2010687 | |||||||||
| Expr2028926 | |||||||||
| Drives_construct | WBCnstr00004993 | ||||||||
| WBCnstr00037590 | |||||||||
| Construct_product | WBCnstr00037590 | ||||||||
| Microarray_results (17) | |||||||||
| Expression_cluster (149) | |||||||||
| Interaction (41) | |||||||||
| Map_info | Map | II | Position | 1.72346 | Error | 0.001468 | |||
| Positive | Positive_clone | T10B9 | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Mapping_data | Multi_point | 4181 | |||||||
| Pseudo_map_position | |||||||||
| Reference | WBPaper00031939 | ||||||||
| WBPaper00038491 | |||||||||
| WBPaper00038729 | |||||||||
| WBPaper00042257 | |||||||||
| WBPaper00055090 | |||||||||
| WBPaper00058833 | |||||||||
| WBPaper00062515 | |||||||||
| WBPaper00064598 | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
