WormBase Tree Display for Gene: WBGene00000388

WBGene00000388 SMap: S_parent: Sequence: ZK637
  Identity: Version: 1
    Name: CGC_name: cdc-25.3
      Sequence_name: ZK637.11
      Molecular_name: ZK637.11
        ZK637.11.1
        CE00429
      Other_name: CELE_ZK637.11 Accession_evidence: NDB BX284603
      Public_name: cdc-25.3
    DB_info: Database (12)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:20 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: cdc
    Allele (25)
    Strain: WBStrain00002130
      WBStrain00001389
      WBStrain00031390
    RNASeq_FPKM (74)
    GO_annotation (18)
    Ortholog (34)
    Paralog: WBGene00000386 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00000387 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00000389 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
    Structured_description: Concise_description: cdc-25.3 encodes a tyrosine phosphatase that is a member of the cell division cycle 25 (CDC25) family of cell cycle regulators that includes Schizosaccharomyces pombe CDC25 and Drosophila string; cdc-25.3 is one of four cdc-25 genes in C. elegans and while it is known to be expressed in hermaphrodites, the precise function of cdc-25.3 is not yet clear; cdc-25.3 may function redundantly with cdc-25.2 during embryonic development and redundantly with cdc-25.1, cdc-25.2, and emb-29 during meiosis. Paper_evidence: WBPaper00003164
            WBPaper00011225
            WBPaper00017563
          Curator_confirmed: WBPerson1843
            WBPerson324
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Predicted to enable protein tyrosine phosphatase activity. Predicted to be involved in G2/M transition of mitotic cell cycle; positive regulation of G2/M transition of mitotic cell cycle; and positive regulation of G2/MI transition of meiotic cell cycle. Located in nucleus. Expressed in ABa; ABp; and germ line. Human ortholog(s) of this gene implicated in several diseases, including autosomal recessive polycystic kidney disease; endometrial hyperplasia; and reproductive organ cancer (multiple). Is an ortholog of human CDC25A (cell division cycle 25A); CDC25B (cell division cycle 25B); and CDC25C (cell division cycle 25C). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:11054 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1725,HGNC:1726)
      DOID:3459 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1725,HGNC:1726)
      DOID:0110861 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1725)
      DOID:2101 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1725,HGNC:1726,HGNC:1727)
      DOID:0080365 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1726,HGNC:1727)
      DOID:10283 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1725,HGNC:1726,HGNC:1727)
      DOID:4362 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1725,HGNC:1727)
      DOID:1612 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1727)
      DOID:1380 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1726,HGNC:1727)
  Molecular_info: Corresponding_CDS: ZK637.11
    Corresponding_transcript: ZK637.11.1
    Other_sequence (13)
    Associated_feature: WBsf651318
      WBsf651319
      WBsf993515
      WBsf227209
  Experimental_info: RNAi_result: WBRNAi00022096 Inferred_automatically: RNAi_primary
      WBRNAi00038381 Inferred_automatically: RNAi_primary
      WBRNAi00059582 Inferred_automatically: RNAi_primary
      WBRNAi00110768 Inferred_automatically: RNAi_primary
      WBRNAi00059581 Inferred_automatically: RNAi_primary
      WBRNAi00005830 Inferred_automatically: RNAi_primary
    Expr_pattern (12)
    Drives_construct: WBCnstr00000434
      WBCnstr00004288
      WBCnstr00037578
    Construct_product: WBCnstr00000434
      WBCnstr00037578
    Microarray_results (19)
    Expression_cluster (186)
    Interaction (145)
  Map_info: Map: III Position: 0.040793 Error: 0.003949
    Positive: Positive_clone: ZK637 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4187
        4764
        5435
        5518
    Pseudo_map_position
  Reference (28)
  Remark: email 16 from wen chen
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene