WormBase Tree Display for Gene: WBGene00000447

WBGene00000447 SMap: S_parent: Sequence: F55B12
  Identity: Version: 1
    Name: CGC_name: ceh-24 Person_evidence: WBPerson83
      Sequence_name: F55B12.1
      Molecular_name: F55B12.1
        F55B12.1.1
        CE25006
      Other_name: CELE_F55B12.1 Accession_evidence: NDB BX284605
      Public_name: ceh-24
    DB_info: Database: AceView gene 5O295
        WormQTL gene WBGene00000447
        WormFlux gene WBGene00000447
        NDB locus_tag CELE_F55B12.1
        Panther gene CAEEL|WormBase=WBGene00000447|UniProtKB=Q9NLC2
          family PTHR24340
        NCBI gene 179877
        RefSeq protein NM_074018.5
        SwissProt UniProtAcc Q9NLC2
        UniProt_GCRP UniProtAcc Q9NLC2
        OMIM gene 600635
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:20 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: ceh
    Allele (38)
    Legacy_information: [C.elegansII] pk92 : Tc1 insertion, no known phenotype.Encodes NK class homeoprotein. ceh-24:lacZ expressed in pharynx muscle m8, vulval muscles,some head neurons. [PD]
    Strain: WBStrain00030582
      WBStrain00030580
      WBStrain00030581
      WBStrain00008317
      WBStrain00048954
      WBStrain00051837
    RNASeq_FPKM (74)
    GO_annotation (14)
    Ortholog: WBGene00052885 Caenorhabditis remanei From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00032588 Caenorhabditis briggsae From_analysis: Hillier-set
            OrthoMCL
            OMA
            Inparanoid_8
            WormBase-Compara
      WBGene00156749 Caenorhabditis brenneri From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00122388 Caenorhabditis japonica From_analysis: TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00231872 Brugia malayi From_analysis: WormBase-Compara
      CBOVI.g2143 Caenorhabditis bovis From_analysis: WormBase-Compara
      CSP21.g11485 Caenorhabditis parvicauda From_analysis: WormBase-Compara
      CSP26.g10003 Caenorhabditis zanzibari From_analysis: WormBase-Compara
      CSP28.g4508 Caenorhabditis panamensis From_analysis: WormBase-Compara
      CSP29.g18062 Caenorhabditis becei From_analysis: WormBase-Compara
      CSP31.g451 Caenorhabditis uteleia From_analysis: WormBase-Compara
      CSP32.g9112 Caenorhabditis sulstoni From_analysis: WormBase-Compara
      CSP38.g7175 Caenorhabditis quiockensis From_analysis: WormBase-Compara
      CSP39.g2404 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      CSP40.g7669 Caenorhabditis tribulationis From_analysis: WormBase-Compara
      Cni-ceh-24 Caenorhabditis nigoni From_analysis: WormBase-Compara
      Csp11.Scaffold629.g14265 Caenorhabditis tropicalis From_analysis: WormBase-Compara
      Csp5_scaffold_03031.g28831 Caenorhabditis sinica From_analysis: WormBase-Compara
      FL83_03742 Caenorhabditis latens From_analysis: WormBase-Compara
      GCK72_018656 Caenorhabditis remanei From_analysis: WormBase-Compara
      Pan_g14710 Panagrellus redivivus From_analysis: WormBase-Compara
      Sp34_50168300 Caenorhabditis inopinata From_analysis: WormBase-Compara
      chrV_pilon.g16333 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00202633 Pristionchus pacificus From_analysis: WormBase-Compara
      WBGene00263708 Strongyloides ratti From_analysis: WormBase-Compara
      WBGene00285801 Trichuris muris From_analysis: WormBase-Compara
      FB:FBgn0287186 Drosophila melanogaster From_analysis: EnsEMBL-Compara
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-000830-1 Danio rerio From_analysis: EnsEMBL-Compara
            Inparanoid
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-010404-1 Danio rerio From_analysis: EnsEMBL-Compara
            Inparanoid
            OrthoInspector
            Panther
            SonicParanoid
      ZFIN:ZDB-GENE-030131-6336 Danio rerio From_analysis: EnsEMBL-Compara
            Inparanoid
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      HGNC:11825 Homo sapiens From_analysis: EnsEMBL-Compara
            Inparanoid
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      HGNC:7837 Homo sapiens From_analysis: EnsEMBL-Compara
            Inparanoid
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      MGI:108067 Mus musculus From_analysis: EnsEMBL-Compara
            Inparanoid
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      MGI:97349 Mus musculus From_analysis: EnsEMBL-Compara
            OrthoInspector
            Panther
            SonicParanoid
      RGD:3866 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Inparanoid
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      RGD:1304985 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Inparanoid
            OrthoInspector
            Panther
            SonicParanoid
    Paralog: WBGene00000428 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00000434 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00000445 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00000450 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00000449 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00000584 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
    Structured_description: Concise_description: ceh-24 encodes an NK class homeodomain protein orthologous to human NK2 Homeobox 1 (NKX2-1; OMIM:600635) which is expressed in the thyroid, lung, and bronchial epithelia and which, when mutated, leads to disease. Curator_confirmed: WBPerson1843
            WBPerson1823
            WBPerson567
          Date_last_updated: 29 Oct 2009 00:00:00
      Automated_description: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in cell differentiation; regulation of transcription by RNA polymerase II; and regulation of transcription elongation by RNA polymerase II. Predicted to be located in nucleus. Expressed in head muscle; intestine; neurons; non-striated muscle; and ventral nerve cord. Human ortholog(s) of this gene implicated in choreatic disease and thyroid gland papillary carcinoma. Is an ortholog of human NKX2-1 (NK2 homeobox 1) and NKX2-4 (NK2 homeobox 4). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:3969 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:11825)
      DOID:12859 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:11825)
  Molecular_info: Corresponding_CDS: F55B12.1
    Corresponding_transcript: F55B12.1.1
    Other_sequence: FD515256.1
      ACC33915_1
      EY472969.1
      Oden_isotig14746
      MIC05372_1
      Oden_isotig14745
      MI06369
      CSC01139_1
      JI169963.1
    Associated_feature: WBsf647488
      WBsf662047
      WBsf919538
      WBsf919539
      WBsf978299
      WBsf1001892
      WBsf1001893
      WBsf1001894
      WBsf1020764
      WBsf232828
    Transcription_factor: WBTranscriptionFactor000318
  Experimental_info: RNAi_result (16)
    Expr_pattern (18)
    Drives_construct (16)
    Construct_product: WBCnstr00010279
      WBCnstr00016692
      WBCnstr00018732
      WBCnstr00018733
      WBCnstr00019836
      WBCnstr00037530
    Microarray_results (20)
    Expression_cluster (93)
    Interaction (35)
    WBProcess: WBbiopr:00000040
  Map_info: Map: V Position: 5.59946 Error: 0.002711
    Positive: Positive_clone: F55B12 Inferred_automatically: From sequence, transcript, pseudogene data
        PD#BH911
    Mapping_data: Multi_point: 4207
        5333
    Pseudo_map_position
  Reference (32)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene