WormBase Tree Display for Gene: WBGene00000481
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| WBGene00000481 | SMap | S_parent | Sequence | ZC416 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | cha-1 | Person_evidence | WBPerson1417 | |||||
| Sequence_name | ZC416.8 | ||||||||
| Molecular_name | ZC416.8b | ||||||||
| ZC416.8b.1 | |||||||||
| CE17308 | |||||||||
| Other_name | CELE_CHA-1 | Accession_evidence | NDB | BX284604 | |||||
| Public_name | cha-1 | ||||||||
| DB_info | Database (12) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:21 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | cha | ||||||||
| Reference_allele | WBVar00095135 | ||||||||
| Allele (205) | |||||||||
| Legacy_information | p1152 : 99% reduced choline acetyltransferase slow-growing uncoordinated (coiler) resistant to aldicarb trichlorfon. ES3. NA6 (b401ts (ME2) p1154 etc.) One cha-1 allele p1156 fails to complement unc-17 and unc- 17 alleles e113 and e876 fail to complement cha-1. See also unc-17. | ||||||||
| [Jim Thomas] Defecation cycle variable in length, often extremely long in all alleles tested. | |||||||||
| See also m324 | |||||||||
| [C.elegansII] p1152 : 99% reduced choline acetyltransferase, slow-growing, uncoordinated (coiler), Ric (resistant to aldicarb, trichlorfon); slow pumping. ES3. OA>10: m324 (lethal, probable null),b401ts (ME2), p1154, p1156 (anomalous allele, fails to complement unc-17), cn101,n2411 etc. Defecation cycle variable in length, often extremely long in all alleles tested. unc-17 alleles e113, e876 fail to complement cha-1. Cloned : encodes choline acetyltransferase, 37% identical to pig enzyme, 28% to Drosophila enzyme. Antibody staining cytosolic, in motor neurons.Shares 5' UTR exon with unc-17. [Rand 1989; Alfonso et al. 1994; RM; JT; DR; DA] | |||||||||
| [Jacobson LA] p1152 : phenotype wild-type at 20C or below; Uncoordinated (coiler) at 25C, 100% penetrance; (Reversible after temperature downshift) | |||||||||
| Strain (14) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (21) | |||||||||
| Ortholog (39) | |||||||||
| Paralog | WBGene00021703 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00021002 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00019644 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00020911 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00011850 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00009622 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00008629 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00012907 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00007175 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00011122 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | cha-1 is part of a gene complex, in which it shares a common promoter and first (noncoding) exon with unc-17 (and is thus coexpressed with unc-17), but in which the two genes encode mutationally separable functions; cha-1 encodes a choline acetyltransferase that synthesizes acetylcholine, is expressed in neurons, and is required for viability, normal growth, locomotion, and sensitivity to acetylcholinesterase inhibitors. | Paper_evidence | WBPaper00000675 | |||||
| WBPaper00001938 | |||||||||
| WBPaper00002015 | |||||||||
| WBPaper00002195 | |||||||||
| WBPaper00002590 | |||||||||
| Curator_confirmed | WBPerson567 | ||||||||
| Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
| Automated_description | Enables choline O-acetyltransferase activity. Involved in acetylcholine biosynthetic process. Located in several cellular components, including cytosol; excitatory synapse; and neuronal cell body. Expressed in IL2 neuron. Human ortholog(s) of this gene implicated in Alzheimer's disease and congenital myasthenic syndrome 6. Is an ortholog of human CHAT (choline O-acetyltransferase). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:10652 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1912) | ||||
| DOID:0110671 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1912) | ||||||
| Molecular_info | Corresponding_CDS | ZC416.8b | |||||||
| Corresponding_transcript | ZC416.8b.1 | ||||||||
| Other_sequence (19) | |||||||||
| Associated_feature | WBsf995999 | ||||||||
| WBsf996000 | |||||||||
| WBsf996001 | |||||||||
| WBsf996002 | |||||||||
| WBsf1017092 | |||||||||
| WBsf1017093 | |||||||||
| WBsf1017094 | |||||||||
| WBsf1017095 | |||||||||
| WBsf229907 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00001082 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00027619 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00102775 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr7819 | ||||||||
| Expr11449 | |||||||||
| Expr1026272 | |||||||||
| Expr1030283 | |||||||||
| Expr2009949 | |||||||||
| Expr2028189 | |||||||||
| Drives_construct | WBCnstr00037505 | ||||||||
| Construct_product | WBCnstr00037505 | ||||||||
| Antibody | WBAntibody00001332 | ||||||||
| WBAntibody00001333 | |||||||||
| WBAntibody00001334 | |||||||||
| WBAntibody00001335 | |||||||||
| WBAntibody00001336 | |||||||||
| Microarray_results | 172037_x_at | ||||||||
| 188870_s_at | |||||||||
| A_12_P110801 | |||||||||
| Aff_ZC416.8B | |||||||||
| GPL13394_WBGene00000481 | |||||||||
| GPL13914_ZC416.8 | |||||||||
| GPL14144_ZC416.8b_1046-1105_0.899_9_C | |||||||||
| GPL14144_ZC416.8b_1431-1490_0.943_4_B | |||||||||
| GPL14144_ZC416.8b_1814-1873_0.962_1_A | |||||||||
| GPL19516_CGZ0055864 | |||||||||
| GPL21109_ZC416.8b | |||||||||
| GPL3518_CE17308 | |||||||||
| GPL8304_CE_WBGene00006756_A | |||||||||
| GPL8673_ZC416_8bP00485 | |||||||||
| GPL8673_ZC416_8bP00994 | |||||||||
| GPL8673_ZC416_8bP01688 | |||||||||
| GPL9450_ZC416.8b | |||||||||
| cea2.c.32848 | |||||||||
| Expression_cluster (138) | |||||||||
| Interaction (35) | |||||||||
| Anatomy_function | WBbtf0232 | ||||||||
| Map_info | Map | IV | Position | -3.11541 | Error | 0.003705 | |||
| Well_ordered | |||||||||
| Positive | Positive_clone | RM#2L | |||||||
| ZC416 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||||
| Mapping_data | 2_point | 517 | |||||||
| 523 | |||||||||
| 1644 | |||||||||
| 1645 | |||||||||
| 2838 | |||||||||
| Multi_point (19) | |||||||||
| Reference (173) | |||||||||
| Remark | cha-1 only corresponds to ZC416.8b and not ZC416.8a which instead corresponds to the unc-17 gene. | ||||||||
| Method | Gene |
