WormBase Tree Display for Gene: WBGene00000481
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WBGene00000481 | SMap | S_parent | Sequence | ZC416 | |||||
---|---|---|---|---|---|---|---|---|---|
Identity | Version | 1 | |||||||
Name | CGC_name | cha-1 | Person_evidence | WBPerson1417 | |||||
Sequence_name | ZC416.8 | ||||||||
Molecular_name | ZC416.8b | ||||||||
ZC416.8b.1 | |||||||||
CE17308 | |||||||||
Other_name | CELE_CHA-1 | Accession_evidence | NDB | BX284604 | |||||
Public_name | cha-1 | ||||||||
DB_info | Database (12) | ||||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 07 Apr 2004 11:29:21 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
Status | Live | ||||||||
Gene_info | Biotype | SO:0001217 | |||||||
Gene_class | cha | ||||||||
Reference_allele | WBVar00095135 | ||||||||
Allele (205) | |||||||||
Legacy_information | p1152 : 99% reduced choline acetyltransferase slow-growing uncoordinated (coiler) resistant to aldicarb trichlorfon. ES3. NA6 (b401ts (ME2) p1154 etc.) One cha-1 allele p1156 fails to complement unc-17 and unc- 17 alleles e113 and e876 fail to complement cha-1. See also unc-17. | ||||||||
[Jim Thomas] Defecation cycle variable in length, often extremely long in all alleles tested. | |||||||||
See also m324 | |||||||||
[C.elegansII] p1152 : 99% reduced choline acetyltransferase, slow-growing, uncoordinated (coiler), Ric (resistant to aldicarb, trichlorfon); slow pumping. ES3. OA>10: m324 (lethal, probable null),b401ts (ME2), p1154, p1156 (anomalous allele, fails to complement unc-17), cn101,n2411 etc. Defecation cycle variable in length, often extremely long in all alleles tested. unc-17 alleles e113, e876 fail to complement cha-1. Cloned : encodes choline acetyltransferase, 37% identical to pig enzyme, 28% to Drosophila enzyme. Antibody staining cytosolic, in motor neurons.Shares 5' UTR exon with unc-17. [Rand 1989; Alfonso et al. 1994; RM; JT; DR; DA] | |||||||||
[Jacobson LA] p1152 : phenotype wild-type at 20C or below; Uncoordinated (coiler) at 25C, 100% penetrance; (Reversible after temperature downshift) | |||||||||
Strain (14) | |||||||||
RNASeq_FPKM (74) | |||||||||
GO_annotation (21) | |||||||||
Ortholog (39) | |||||||||
Paralog | WBGene00021703 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
Panther | |||||||||
WormBase-Compara | |||||||||
WBGene00021002 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
Panther | |||||||||
WormBase-Compara | |||||||||
WBGene00019644 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
Panther | |||||||||
WormBase-Compara | |||||||||
WBGene00020911 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
Panther | |||||||||
WormBase-Compara | |||||||||
WBGene00011850 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
Panther | |||||||||
WormBase-Compara | |||||||||
WBGene00009622 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
Panther | |||||||||
WormBase-Compara | |||||||||
WBGene00008629 | Caenorhabditis elegans | From_analysis | Panther | ||||||
WormBase-Compara | |||||||||
WBGene00012907 | Caenorhabditis elegans | From_analysis | Panther | ||||||
WormBase-Compara | |||||||||
WBGene00007175 | Caenorhabditis elegans | From_analysis | Panther | ||||||
WormBase-Compara | |||||||||
WBGene00011122 | Caenorhabditis elegans | From_analysis | Panther | ||||||
WormBase-Compara | |||||||||
Structured_description | Concise_description | cha-1 is part of a gene complex, in which it shares a common promoter and first (noncoding) exon with unc-17 (and is thus coexpressed with unc-17), but in which the two genes encode mutationally separable functions; cha-1 encodes a choline acetyltransferase that synthesizes acetylcholine, is expressed in neurons, and is required for viability, normal growth, locomotion, and sensitivity to acetylcholinesterase inhibitors. | Paper_evidence | WBPaper00000675 | |||||
WBPaper00001938 | |||||||||
WBPaper00002015 | |||||||||
WBPaper00002195 | |||||||||
WBPaper00002590 | |||||||||
Curator_confirmed | WBPerson567 | ||||||||
Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
Automated_description | Enables choline O-acetyltransferase activity. Involved in acetylcholine biosynthetic process. Located in several cellular components, including cytosol; excitatory synapse; and neuronal cell body. Expressed in IL2 neuron. Human ortholog(s) of this gene implicated in Alzheimer's disease and congenital myasthenic syndrome 6. Is an ortholog of human CHAT (choline O-acetyltransferase). | Paper_evidence | WBPaper00065943 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
WBPerson37462 | |||||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
Disease_info | Potential_model | DOID:10652 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1912) | ||||
DOID:0110671 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1912) | ||||||
Molecular_info | Corresponding_CDS | ZC416.8b | |||||||
Corresponding_transcript | ZC416.8b.1 | ||||||||
Other_sequence (19) | |||||||||
Associated_feature | WBsf995999 | ||||||||
WBsf996000 | |||||||||
WBsf996001 | |||||||||
WBsf996002 | |||||||||
WBsf1017092 | |||||||||
WBsf1017093 | |||||||||
WBsf1017094 | |||||||||
WBsf1017095 | |||||||||
WBsf229907 | |||||||||
Experimental_info | RNAi_result | WBRNAi00001082 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00027619 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00102775 | Inferred_automatically | RNAi_primary | |||||||
Expr_pattern | Expr7819 | ||||||||
Expr11449 | |||||||||
Expr1026272 | |||||||||
Expr1030283 | |||||||||
Expr2009949 | |||||||||
Expr2028189 | |||||||||
Drives_construct | WBCnstr00037505 | ||||||||
Construct_product | WBCnstr00037505 | ||||||||
Antibody | WBAntibody00001332 | ||||||||
WBAntibody00001333 | |||||||||
WBAntibody00001334 | |||||||||
WBAntibody00001335 | |||||||||
WBAntibody00001336 | |||||||||
Microarray_results (18) | |||||||||
Expression_cluster (138) | |||||||||
Interaction (35) | |||||||||
Anatomy_function | WBbtf0232 | ||||||||
Map_info | Map | IV | Position | -3.11541 | Error | 0.003705 | |||
Well_ordered | |||||||||
Positive | Positive_clone | RM#2L | |||||||
ZC416 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||||
Mapping_data (2) | |||||||||
Reference (173) | |||||||||
Remark | cha-1 only corresponds to ZC416.8b and not ZC416.8a which instead corresponds to the unc-17 gene. | ||||||||
Method | Gene |