WormBase Tree Display for Gene: WBGene00000585

WBGene00000585 SMap: S_parent: Sequence: C06G3
  Identity: Version: 2
    Name: CGC_name: cogc-2 Paper_evidence: WBPaper00026979
          Person_evidence: WBPerson449
      Sequence_name: C06G3.10
      Molecular_name: C06G3.10
        C06G3.10.1
        CE28817
      Other_name: cog2 Accession_evidence: EMBL Z34976
        cgo-2
        CELE_C06G3.10 Accession_evidence: NDB BX284604
      Public_name: cogc-2
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:21 WBPerson1971 Event: Imported: Initial conversion from geneace
        2 17 Jan 2006 13:29:50 WBPerson2970 Name_change: CGC_name: cogc-2
                Other_name: cgo-2
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: cogc
    Allele (33)
    RNASeq_FPKM (74)
    GO_annotation (12)
    Contained_in_operon: CEOP4208
    Ortholog (28)
    Structured_description: Concise_description: cogc-2 encodes an ortholog of mammalian COG-2, a subunit of lobe A ofthe conserved oligomeric Golgi complex (COGC); COGC-2 is required fornormal gonadal distal tip cell migration, a process that also requiresseven other orthologs of COGC subunits; like other lobe A subunits inboth C. elegans and S. cerevisiae, COGC-2 is strongly required fornormal function, while lobe B subunits are only partially required ineither worms or yeast. Paper_evidence: WBPaper00026979
            WBPaper00028363
            WBPaper00028599
            WBPaper00028603
          Curator_confirmed: WBPerson567
          Date_last_updated: 25 Oct 2006 00:00:00
      Automated_description: Involved in gonad morphogenesis and regulation of cell migration. Predicted to be located in Golgi membrane. Predicted to be part of Golgi transport complex. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type IIq. Is an ortholog of human COG2 (component of oligomeric golgi complex 2). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0070269 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:6546)
  Molecular_info: Corresponding_CDS: C06G3.10
    Corresponding_transcript: C06G3.10.1
    Other_sequence (23)
    Associated_feature: WBsf651882
      WBsf981776
      WBsf230214
      WBsf230215
  Experimental_info: RNAi_result (36)
    Expr_pattern: Expr1021050
      Expr1030345
      Expr1144006
      Expr2010291
      Expr2028533
    Drives_construct: WBCnstr00037444
    Construct_product: WBCnstr00037444
    Microarray_results (19)
    Expression_cluster: WBPaper00031040:TGF-beta_adult_downregulated
      WBPaper00033065:cyc-1(RNAi)_downregulated
      WBPaper00033070:Elbe_upregulated
      WBPaper00036375:enriched_in_PVD_OLL
      WBPaper00037950:all-neurons_L1-larva_expressed
      WBPaper00037950:all-neurons_L2-larva_expressed
      WBPaper00037950:AVA-neuron_L1-larva_expressed
      WBPaper00037950:AVE-neuron_L1-larva_expressed
      WBPaper00037950:bodywall-muscle_L1-larva_expressed
      WBPaper00037950:bodywall-muscle_L2-larva_expressed
      WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
      WBPaper00037950:coelomocytes_L1-larva_expressed
      WBPaper00037950:dopaminergic-neurons_L1-larva_expressed
      WBPaper00037950:excretory-cell_L2-larva_expressed
      WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed
      WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed
      WBPaper00037950:hypodermis_L1-larva_expressed
      WBPaper00037950:hypodermis_L3-L4-larva_expressed
      WBPaper00037950:intestine_L1-larva_expressed
      WBPaper00037950:intestine_L2-larva_expressed
      WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
      WBPaper00044736:flat_dev_expression
      WBPaper00045571:germline-ablation_downregulated
      WBPaper00046691:P1_enriched
      WBPaper00048923:Aging_regulated
      WBPaper00048926:miaserin_upregulated_adult-day3
      WBPaper00048988:neuron_expressed
      WBPaper00049545:cco-1(RNAi)_downregulated
      WBPaper00049545:jmjd-3.1(+)_downregulated
      WBPaper00049920:Glucose-Diet_downregulated_hyl-2(tm2031)
      WBPaper00049920:Glucose-Diet_downregulated_N2
      WBPaper00050412:cco-1(RNAi)_downregulated_N2
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050859:downregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:downregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00051039:germline_enriched
      WBPaper00051245:epidermis_cytoplasm_expressed
      WBPaper00051265:F4_morc-1(tm6048)_upregulated
      WBPaper00052884:emb-4(hc60)_downregulated
      WBPaper00053184:sma-2(rax5)_downregulated
      WBPaper00053184:sma-4(rax3)_downregulated
      WBPaper00053289:DREAM-target
      WBPaper00053302:alovudine_24h_regulated
      WBPaper00053302:stavudine_24h_regulated
      WBPaper00053302:zidovudine_72h_regulated
      WBPaper00053308:SMG-2_associated_NMD(-)_unaltered_ClassII
      WBPaper00053388:dauer_regulated_Cluster5
      WBPaper00053810:daf-2(e1370)_downregulated
      WBPaper00053810:nuo-6(qm200)_downregulated
      WBPaper00055060:flr-1(RNAi)_upregulated
      WBPaper00055482:pmt-2(RNAi)_downregulated
      WBPaper00055565:AVK_enriched
      WBPaper00055648:germline_expressed
      WBPaper00056034:pals-22(jy3)_downregulated
      WBPaper00056161:male_enriched_siRNA
      WBPaper00056443:sek-1(km4)_downregulated
      WBPaper00057006:DietaryRestriction_downregulated
      WBPaper00057288:Cold_downregulated_transcript
      WBPaper00057288:iff-1(RNAi)_downregulated_transcript
      WBPaper00058886:anp-1(ok608)_downregulated
      WBPaper00059174:MEG-3_interacting
      WBPaper00059356:BAZ-2_SET-6_interacting
      WBPaper00059471:EGL-43_interacting
      WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
      WBPaper00060358:B.thuringiensis_pathogen_regulated_N2
      WBPaper00060661:sensory-neuron_depleted
      WBPaper00060683:hlh-11(ko1)_downregulated
      WBPaper00061340:K_Kprime
      WBPaper00061340:Pharyngeal_marginal_cell
      WBPaper00061439:unc-30(ok613)_downregulated
      WBPaper00061478:SUMO-conjugated_protein
      WBPaper00061527:172183_at-176110_at
      WBPaper00061527:npp-8_4355-afd-1_4796
      WBPaper00061527:T02E1.2-uri-1
      WBPaper00061902:camt-1(ok515)_regulated_RMG
      WBPaper00063930:BRD-1_interacting
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_fem-3(q20)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_fem-3(q20)
      WBPaper00064201:SNA-3_interacting
      WBPaper00064716:paraquat_upregulated
      WBPaper00064769:him-17(me24)_downregulated
      WBPaper00064871:hypoxia_upregulated_F1
      WBPaper00065096:Day10_vs_Day1_upregulated
      WBPaper00065373:sek-1(km4)_downregulated_cisplatin
      WBPaper00065993:glp-1(e2141)_downregulated
      WBPaper00066062:xrep-4(lax137)_upregulated
      WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14
      WBPaper00025032:cluster_176
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00032165:differentially_expressed_with_age_medoid_5
      WBPaper00034739:N2moreDR1350
      WBPaper00035873:dpy-10_regulated
      WBPaper00035905:FBF-1_Associated
      WBPaper00036286:Pattern_H
      WBPaper00037695:LD_DD_6-day
      WBPaper00038060:SUMO-1_upregulated
      WBPaper00041002:HF_3d_2.0mM_Down
      WBPaper00041002:HQ_3d_0.2mM_Down
      WBPaper00041606:CE_B.thuringiensis-DB27_regulated
      WBPaper00041606:CE_S.marcescens_regulated
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00042258:DA1877_downregulated_GravidAdult
      WBPaper00046853:AOBr_M.aeruginosa-batch-culture_upregulated
      WBPaper00048989:eat-2(ad465)_rapamycin_upregulated
      WBPaper00048989:N2_allantoin_upregulated
      WBPaper00053236:Starvation_regulated_N2
      WBPaper00057098:SiO2-nanoparticles_upregulated
      [cgc5767]:expression_class_E
      [cgc5767]:expression_class_E_pi(122_min)
      [cgc5767]:expression_class_M
      [cgc5767]:expression_class_MD
      [cgc5767]:expression_class_MDE
      [cgc5767]:expression_class_MD_pd(23_min)
      [cgc5767]:expression_class_ME
      [cgc6390]:intrinsic
    Interaction (19)
  Map_info: Map: IV Position: 3.27829 Error: 0.000592
    Positive: Positive_clone: C06G3 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00027766
    WBPaper00038491
    WBPaper00055090
    WBPaper00061547
  Remark: C06G3.10 was incorrectly linked to cog-2. C06G3.10 is required for normal Golgi morphology and function and has nothing to do with cog - Connection Of Gonad defective. The EMBL gene name cog2 refers to a Golgi-localized protein complex. However, "cog" is not CGC approved CGC_data_submission
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene