cogc-2 encodes an ortholog of mammalian COG-2, a subunit of lobe A ofthe conserved oligomeric Golgi complex (COGC); COGC-2 is required fornormal gonadal distal tip cell migration, a process that also requiresseven other orthologs of COGC subunits; like other lobe A subunits inboth C. elegans and S. cerevisiae, COGC-2 is strongly required fornormal function, while lobe B subunits are only partially required ineither worms or yeast.
Involved in gonad morphogenesis and regulation of cell migration. Predicted to be located in Golgi membrane. Predicted to be part of Golgi transport complex. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type IIq. Is an ortholog of human COG2 (component of oligomeric golgi complex 2).
C06G3.10 was incorrectly linked to cog-2. C06G3.10 is required for normal Golgi morphology and function and has nothing to do with cog - Connection Of Gonad defective. The EMBL gene name cog2 refers to a Golgi-localized protein complex. However, "cog" is not CGC approved
CGC_data_submission
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.