WormBase Tree Display for Gene: WBGene00000830

WBGene00000830 SMap: S_parent: Sequence: Y54G11A
  Identity: Version: 1
    Name: CGC_name: ctl-1 Person_evidence: WBPerson95
      Sequence_name: Y54G11A.6
      Molecular_name: Y54G11A.6
        Y54G11A.6.1
        CE30713
      Other_name: cat2 Accession_evidence: EMBL Y14065
              Y14066
        CELE_Y54G11A.6 Accession_evidence: NDB BX284602
      Public_name: ctl-1
    DB_info: Database (13)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:21 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: ctl
    Allele (26)
    Strain: WBStrain00031898
    RNASeq_FPKM (74)
    GO_annotation (20)
    Ortholog (42)
    Paralog: WBGene00000831 Caenorhabditis elegans From_analysis: Inparanoid_8
            Panther
            WormBase-Compara
      WBGene00013220 Caenorhabditis elegans From_analysis: TreeFam
            Inparanoid_8
            Panther
            WormBase-Compara
    Structured_description: Concise_description: ctl-1 encodes one of three C. elegans catalases; CTL-1 exhibits catalase activity in vitro, and thus likely functions in vivo as an antioxidant enzyme that protects cells from reactive oxygen species; ctl-1 activity contributes to the extended lifespan seen in daf-2 mutant animals; in addition, ctl-1 expression is negatively regulated by DAF-2-mediated insulin signaling; as CTL-1 does not possess a C-terminal peroxisomal targeting signal (PTS), it is predicted to be a cytosolic catalase. Paper_evidence: WBPaper00003973
            WBPaper00005976
            WBPaper00006515
          Curator_confirmed: WBPerson48
            WBPerson1843
          Date_last_updated: 23 May 2006 00:00:00
      Automated_description: Enables catalase activity. Predicted to be involved in hydrogen peroxide catabolic process and response to hydrogen peroxide. Predicted to be located in mitochondrion and peroxisome. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); eye disease (multiple); and lung disease (multiple). Is an ortholog of human CAT (catalase). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model (48)
  Molecular_info: Corresponding_CDS: Y54G11A.6
    Corresponding_CDS_history: Y54G11A.6:wp78
    Corresponding_transcript: Y54G11A.6.1
    Other_sequence (60)
    Associated_feature: WBsf019139
      WBsf019140
      WBsf019141
      WBsf224261
  Experimental_info: RNAi_result: WBRNAi00063177 Inferred_automatically: RNAi_primary
      WBRNAi00078268 Inferred_automatically: RNAi_primary
      WBRNAi00103092 Inferred_automatically: RNAi_primary
      WBRNAi00030271 Inferred_automatically: RNAi_primary
      WBRNAi00112317 Inferred_automatically: RNAi_primary
      WBRNAi00063176 Inferred_automatically: RNAi_primary
      WBRNAi00063178 Inferred_automatically: RNAi_primary
      WBRNAi00020988 Inferred_automatically: RNAi_primary
      WBRNAi00057425 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr1318
      Expr1320
      Expr1030512
      Expr1160867
      Expr2010575
      Expr2028815
    Drives_construct: WBCnstr00005460
      WBCnstr00037260
    Construct_product: WBCnstr00005460
      WBCnstr00010215
      WBCnstr00037260
    Microarray_results (25)
    Expression_cluster: WBPaper00030894:daf-2(e1370ts)_upregulated
      WBPaper00031040:Cluster_4
      WBPaper00031070:rrf-3_eri-1_upregulated
      WBPaper00033065:cyc-1(RNAi)_upregulated
      WBPaper00033444:BacteriaDiet_regulated
      WBPaper00037047:aging_accelerated_insoluble_protein
      WBPaper00037047:insoluble_protein
      WBPaper00038289:oocyte_protein
      WBPaper00040990:PA14_upregulated
      WBPaper00041072:UTX-1_interacting_protein
      WBPaper00041954:ethanol_upregulated
      WBPaper00042215:wdr-23(tm1817)_upregulated
      WBPaper00043951:insoluble_protein_day16_N2
      WBPaper00044427:lbp-5(tm1618)_downregulated
      WBPaper00044753:ahr-1_upregulated
      WBPaper00045521:Gender_Neutral
      WBPaper00045618:puf-8_upregulated
      WBPaper00045729:gld-2(RNAi)_upregulated
      WBPaper00046337:monosomal_N2_vs_daf-2_downregulated
      WBPaper00046337:polysomal_daf-2_vs_daf-2;daf-16_downregulated
      WBPaper00046337:polysomal_N2_vs_daf-2_downregulated
      WBPaper00046509:lin-35(n745)_downregulated
      WBPaper00048910:Apoptosis-induced_mRNA-interacting_protein
      WBPaper00048910:mRNA-interacting_protein
      WBPaper00048971:daf-16(mgDf50)_downregulated_L1
      WBPaper00048988:neuron_expressed
      WBPaper00049325:CB4856_vs_N2_DEG
      WBPaper00049736:daf-2(e1370)_upregulated_15deg-then-25deg(12hr)
      WBPaper00049942:hsf-1(RNAi)_downregulated
      WBPaper00050121:mir-60(n4947)_upregulated
      WBPaper00050234:lin-28(RNAi)_downregulated
      WBPaper00050344:ASER-neuron_enriched
      WBPaper00050344:PLM-neuron_enriched
      WBPaper00050370:dpy-21(e428)_L3_downregulated
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
      WBPaper00050599:nicotine(0.01mM)_upregulated
      WBPaper00050599:nicotine(1mM)_upregulated
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00051039:intestine_enriched
      WBPaper00051245:epidermis_cytoplasm_expressed
      WBPaper00051245:intestine_cytoplasm_expressed
      WBPaper00051245:intestine_nucleus_expressed
      WBPaper00052884:emb-4(hc60)_upregulated
      WBPaper00053295:lin-22(ot267)_downregulated
      WBPaper00053295:lin-22(ot269)_downregulated
      WBPaper00053318:Aging_upregulated_mRNA_N2
      WBPaper00053318:mir-71(n4115)_upregulated_mRNA
      WBPaper00053321:nos-1(gv5)nos-2(RNAi)_downregulated_L1_SMARTseq
      WBPaper00053321:PGCs_enriched_NuGen
      WBPaper00053388:dauer_regulated_Cluster2
      WBPaper00053713:Starvation-induced_postdauer_vs_control_upregulated
      WBPaper00053810:daf-2(e1370)_upregulated
      WBPaper00053810:nuo-6(qm200)_upregulated
      WBPaper00055226:ADR-2_target_adr-1(tm668)
      WBPaper00055226:ADR-2_target_N2
      WBPaper00055354:Rapamycin-Rifampicin-Psora_upregulated
      WBPaper00055386:daf-2(e1370)_upregulated
      WBPaper00055626:pry-1(mu38)_upregulated
      WBPaper00055941:atfs-1(et15)_downregulated
      WBPaper00056034:pals-25(jy9)_upregulated
      WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047)
      WBPaper00056139:soil-microbiota_upregulated
      WBPaper00056471:S.aureus-4h_upregulated_N2
      WBPaper00056826:hmc_biased
      WBPaper00056900:TOFU-6_interacting
      WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C
      WBPaper00057041:spc-1(cas971)_downregulated
      WBPaper00057041:unc-70(cas983)_downregulated
      WBPaper00057068:ints-4(RNAi)_downregulated
      WBPaper00057288:Cold_downregulated_protein
      WBPaper00058598:sin-3(tm1276)_downregulated
      WBPaper00058691:WDR-5.1_interacting_protein
      WBPaper00058948:PA14_downregulated
      WBPaper00058958:100mGy-irradiation-72h_upregulated
      WBPaper00058969:RIS_depleted
      WBPaper00059117:B.subtilis_upregulated
      WBPaper00059537:ngn-1(ok2200)_downregulated
      WBPaper00059605:MUT-16_interacting
      WBPaper00059824:rnp-6(dh1127)_regulated_S.aureus
      WBPaper00060014:set-2(zr2012)_upregulated
      WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
      WBPaper00060526:plp-1(ok2155)_downregulated
      WBPaper00060634:fhod-1(tm2363)_upregulated
      WBPaper00060911:prx-5(RNAi)_upregulated_protein
      WBPaper00061203:let-418(n3536)_upregulated
      WBPaper00061203:sin-3(tm1276)_upregulated
      WBPaper00061203:spr-1(ok2144)_upregulated
      WBPaper00061340:RID_parent
      WBPaper00061377:MYRF-1_interacting
      WBPaper00061439:unc-30(ok613)_upregulated
      WBPaper00061466:nath-10(icb99)_downregulated
      WBPaper00061466:nath-10(icb102)_downregulated
      WBPaper00061478:SUMO-conjugated_protein
      WBPaper00061479:hda-1(ne4752)_upregulated
      WBPaper00061479:ubc-9(ne4833)_upregulated
      WBPaper00061527:dhs-28_22199-acs-14
      WBPaper00061613:human-amyloid-beta_upregulated
      WBPaper00061699:daf-18(ok480)_downregulated
      WBPaper00061753:csr-1(tor159)_upregulated_25C
      WBPaper00062056:lin-36(we31)_upregulated
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062193:daf-16(RNAi)_downregulated
      WBPaper00062193:skn-1(RNAi)_upregulated
      WBPaper00062293:isp-1(qm150)_upregulated
      WBPaper00062325:muscle_depleted_coding-RNA
      WBPaper00062554:MAGU-2_interacting
      WBPaper00062590:Aging_downregulated_hypodermis
      WBPaper00062669:extracellular-vesicle_protein
      WBPaper00064005:starvation_upregulated_N2_mRNA
      WBPaper00064071:NHR-49_interacting
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_glp-1(e2141)
      WBPaper00064163:ZNFX-1_interacting_embryo
      WBPaper00064494:postdauer_upregulated_WholeAnimal
      WBPaper00064632:daf-2(e1370)_upregulated_intestine
      WBPaper00064661:lpd-3(ok2138)_upregulated
      WBPaper00064716:paraquat_downregulated
      WBPaper00064727:daf-2(e1370)_upregulated
      WBPaper00064933:bcf-1(ylf1)_downregulated_transcript
      WBPaper00065158:AFD_depleted
      WBPaper00065373:Cisplatin_upregulated_WT
      WBPaper00065373:sek-1(km4)_upregulated_Ref
      WBPaper00065749:Heat-Shock_upregulated_endu-2(tm4977)
      WBPaper00065749:Heat-Shock_upregulated_N2
      WBPaper00065945:epidermis-rpoa-2(-)_upregulated_protein
      WBPaper00065975:P-body_vs_WholeAnimal_depleted
      WBPaper00065984:pals-17(syb3980)_downregulated
      WBPaper00065993:glp-1(e2141)_upregulated
      WBPaper00066004:fust-1(csb21)_downregulated
      WBPaper00066146:germline-inx-14(RNAi)_upregulated_PA14
      WBPaper00025032:cluster_104
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00027111:rde-3(r459)_downregulated
      WBPaper00027111:rrf-1(pk1417)_upregulated
      WBPaper00030985:Enterococcus_faecalis_upregulated
      WBPaper00030985:Erwinia_carotovora_upregulated
      WBPaper00030985:Photorhabdus_luminescens_upregulated
      WBPaper00031003:0hr_muscle_depleted
      WBPaper00031003:24hr_muscle_depleted
      WBPaper00031003:total_muscle_depleted
      WBPaper00031039:mtss-1(RNAi)_upregulated
      WBPaper00031532:Larva_Pan_Neuronal_Depleted
      WBPaper00032165:differentially_expressed_with_age_medoid_7
      WBPaper00034739:N2moreDR1350
      WBPaper00034757:up_by_oxidative_stress
      WBPaper00035504:daf-2(e1370)_upregulated
      WBPaper00035588:alg-1(-)_upregulated
      WBPaper00036286:Pattern_H
      WBPaper00037695:LD_DD_6-day
      WBPaper00038231:Cry5B_1.5-fold_upregulated
      WBPaper00038231:Cry5B_2-fold_upregulated
      WBPaper00040184:hcf-1up_sir-2.1up_daf-2up
      WBPaper00040210:Chlorpyrifos_24C_regulated
      WBPaper00040210:Chlorpyrifos_Diazinon_24C_regulated
      WBPaper00040858:eQTL_age_regulated_aging
      WBPaper00040858:eQTL_regulated_aging
      WBPaper00040858:eQTL_regulated_developing
      WBPaper00040858:eQTL_regulated_juvenile
      WBPaper00040858:eQTL_regulated_old
      WBPaper00040858:eQTL_regulated_reproductive
      WBPaper00041002:HQ_3d_2.0mM_Up
      WBPaper00041370:spg-7(RNAi)_upregulated
      WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
      WBPaper00041939:UVC-EtBr-exposed_vs_EtBr-exposed_48h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_24h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h
      WBPaper00041960:N2_fasting_upregulated_9hto12h
      WBPaper00041960:N2_fasting_upregulated_anytime
      WBPaper00042234:xpa-1_upregulated
      WBPaper00042331:a-SWCNTs_downregulated
      WBPaper00044535:male_downregulated
      WBPaper00045263:nuo-6(qm200)_upregulated
      WBPaper00045865:biofilm_upregulated_A
      WBPaper00045960:L1-L4-lethargus_upregulated
      WBPaper00045960:L4-lethargus_upregulated
      WBPaper00049311:AgNO3_regulated
      WBPaper00053236:Starvation_regulated_GR1307
      WBPaper00053236:Starvation_regulated_N2
      WBPaper00055435:AuNPs_downregulated
      WBPaper00055899:nitrotriazolone_regulated
    Interaction (161)
    WBProcess: WBbiopr:00000039
      WBbiopr:00000096
      WBbiopr:00000121
  Map_info: Map: II Position: 22.9037 Error: 0.000659
    Positive: Positive_clone: Y54G11A Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4241
        4938
    Pseudo_map_position
  Reference (82)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene