WormBase Tree Display for Gene: WBGene00000894
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| WBGene00000894 | Evidence | Person_evidence | WBPerson481 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | M110 | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | dab-1 | Person_evidence | WBPerson194 | |||||
| Sequence_name | M110.5 | ||||||||
| Molecular_name (27) | |||||||||
| Other_name | CELE_M110.5 | Accession_evidence | NDB | BX284602 | |||||
| Public_name | dab-1 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:21 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | dab | ||||||||
| Allele (96) | |||||||||
| Strain | WBStrain00030632 | ||||||||
| WBStrain00035921 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (25) | |||||||||
| Ortholog (38) | |||||||||
| Paralog | WBGene00000420 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| WBGene00009930 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00002176 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00001116 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00003830 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | dab-1 encodes an ortholog of the cytoplasmic adaptor protein DISABLED,required for normal molting and meiotic arrest; DAB-1 is also required forEGL-17 secretion from vulval cells, and thus indirectly for normal sexmyoblast (SM) migration and egg-laying; DAB-1 contains a conserved PTBdomain and signals that confer localization to Golgi-proximal vesicles,and DAB-1 localizes to vesicular structures in vivo; dab-1 is expressed inventral precursor cells, and DAB-1 prevents EGL-17 protein accumulation inthem; dab-1 is also expressed in other cells (anchor cell, sheath cells,etc.) but has no obvious function in them; DAB-1 binds the cytoplasmicdomains of either LRP-1 or LRP-2 in yeast two-hybrid experiments;dab-1(gk291) and dab-1(RNAi) animals have similar defects in molting,EGL-17 secretion from VPCs, SM migration, and egg-laying; dab-1(RNAi) doesnot enhance the SM phenotypes of lrp-1(RNAi) or lrp-2(RNAi), suggestingthat these genes act in concert to promote normal EGL-17 secretion and SMmigration; in vitro, DAB-1 binds to the ear domains of APT-4 (strongly)and of APT-1 and APT-9 (weakly); genetically, dab-1(RNAi) functions aspart of the vab-1 pathway in oocytes inhibiting meiotic maturation, andDAB-1 is found in oocyte cytoplasm. | Paper_evidence | WBPaper00006219 | |||||
| WBPaper00027122 | |||||||||
| WBPaper00027739 | |||||||||
| Curator_confirmed | WBPerson567 | ||||||||
| Date_last_updated | 23 Aug 2006 00:00:00 | ||||||||
| Automated_description | Enables clathrin heavy chain binding activity and protein domain specific binding activity. Involved in several processes, including ecdysis, collagen and cuticulin-based cuticle; egg-laying behavior; and positive regulation of growth rate. Located in cell cortex; clathrin-coated pit; and cytoplasmic vesicle. Expressed in several structures, including P5.ppp; amphid sheath cell; anchor cell; oocyte; and vulval cell. Human ortholog(s) of this gene implicated in autistic disorder and spinocerebellar ataxia type 37. Is an ortholog of human DAB1 (DAB adaptor protein 1). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0050984 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2661) | ||||
| DOID:12849 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2661) | ||||||
| Molecular_info | Corresponding_CDS | M110.5a | |||||||
| M110.5b | |||||||||
| M110.5c | |||||||||
| M110.5d | |||||||||
| M110.5e | |||||||||
| M110.5f | |||||||||
| M110.5g | |||||||||
| M110.5h | |||||||||
| Corresponding_CDS_history | M110.5a:wp119 | ||||||||
| M110.5a:wp136 | |||||||||
| M110.5b:wp119 | |||||||||
| M110.5b:wp136 | |||||||||
| M110.5c:wp119 | |||||||||
| M110.5d:wp136 | |||||||||
| Corresponding_transcript (11) | |||||||||
| Other_sequence (62) | |||||||||
| Associated_feature | WBsf644451 | ||||||||
| WBsf644452 | |||||||||
| WBsf657953 | |||||||||
| WBsf976512 | |||||||||
| WBsf976513 | |||||||||
| WBsf976514 | |||||||||
| WBsf976515 | |||||||||
| WBsf988678 | |||||||||
| WBsf221714 | |||||||||
| WBsf221715 | |||||||||
| Experimental_info | RNAi_result (38) | ||||||||
| Expr_pattern | Expr2796 | ||||||||
| Expr2797 | |||||||||
| Expr2798 | |||||||||
| Expr4830 | |||||||||
| Expr7864 | |||||||||
| Expr1015658 | |||||||||
| Expr1030559 | |||||||||
| Expr1154649 | |||||||||
| Expr2010757 | |||||||||
| Expr2028994 | |||||||||
| Drives_construct | WBCnstr00001840 | ||||||||
| WBCnstr00010951 | |||||||||
| WBCnstr00037215 | |||||||||
| Construct_product | WBCnstr00010951 | ||||||||
| WBCnstr00021682 | |||||||||
| WBCnstr00037215 | |||||||||
| Antibody | WBAntibody00000696 | ||||||||
| WBAntibody00001060 | |||||||||
| Microarray_results (45) | |||||||||
| Expression_cluster (154) | |||||||||
| Interaction (122) | |||||||||
| WBProcess | WBbiopr:00000120 | ||||||||
| Map_info | Map | II | Position | 0.751738 | Error | 0.000698 | |||
| Positive | Positive_clone | M110 | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Mapping_data | Multi_point | 5014 | |||||||
| 4726 | |||||||||
| 5608 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (23) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
