WormBase Tree Display for Gene: WBGene00000898
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WBGene00000898 | SMap | S_parent | Sequence | Y55D5A | |||||
---|---|---|---|---|---|---|---|---|---|
Identity | Version | 1 | |||||||
Name | CGC_name | daf-2 | Person_evidence | WBPerson521 | |||||
Sequence_name | Y55D5A.5 | ||||||||
Molecular_name (19) | |||||||||
Other_name | CELE_Y55D5A.5 | Accession_evidence | NDB | BX284603 | |||||
Public_name | daf-2 | ||||||||
DB_info | Database (14) | ||||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 07 Apr 2004 11:29:21 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
Status | Live | ||||||||
Gene_info (12) | |||||||||
Disease_info | Experimental_model | DOID:9351 | Homo sapiens | Paper_evidence | WBPaper00064218 | ||||
Curator_confirmed | WBPerson324 | ||||||||
Date_last_updated | 07 Nov 2022 00:00:00 | ||||||||
DOID:14330 | Homo sapiens | Paper_evidence | WBPaper00045313 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
Date_last_updated | 26 Jan 2015 00:00:00 | ||||||||
Potential_model (37) | |||||||||
Disease_relevance | Parkinson''s disease (PD) is an age-dependent neurodegenerative disease characterized by the accumulation of alpha-synuclein (alpha-syn) and the selective loss of dopamine (DA) neurons; studies in C. elegans models of alpha-syn proteotoxcity indicate that reduced IGF-1/insulin-like signaling (IIS) suppresses alpha-syn toxicity and DA neurodegeneration; specifically daf-2 mutant worms that overexpress human alpha-syn retain more wild-type DA neurons when compared to alpha-syn worms alone; mutants of daf-16/FOXO, a well-characterized downstream component of the IIS pathway enhanced neurodegeneration, and an intermediate level of neuroprotection was seen in daf-2; daf-16 double mutants overexpressing alpha-syn-GFP in DA neurons; further, RNA interference of glucose-6-phosphate isomerase (gpi-1/GPI), the glycolytic enzyme, enhanced alpha-syn-induced DA neurotoxicity, while it''s overexpression in DA neurons was neuroprotective; further studies in Drosophila and mice confirm that GPI is neuroprotective; these studies indicate that IIS signaling modulates alpha-syn induced DA neurodegeneration, across species. | Homo sapiens | Paper_evidence | WBPaper00045313 | |||||
WBPaper00025083 | |||||||||
WBPaper00031384 | |||||||||
Curator_confirmed | WBPerson324 | ||||||||
Date_last_updated | 26 Jan 2015 00:00:00 | ||||||||
In glucose-fed wild-type animals, the exponential like decline was restored in the active state, indicating that insulin signaling may be involved in regulation of fractal scaling of C. elegans behavior. | Homo sapiens | Curator_confirmed | WBPerson324 | ||||||
Models_disease_in_annotation | WBDOannot00000339 | ||||||||
Models_disease_asserted | WBDOannot00001356 | ||||||||
Molecular_info | Corresponding_CDS (6) | ||||||||
Corresponding_CDS_history | Y55D5A.5:wp187 | ||||||||
Y55D5A.5a:wp229 | |||||||||
Y55D5A.5b:wp229 | |||||||||
Y55D5A.5b:wp247 | |||||||||
Corresponding_transcript | Y55D5A.5b | ||||||||
Y55D5A.5a.1 | |||||||||
Y55D5A.5c.1 | |||||||||
Y55D5A.5d.1 | |||||||||
Y55D5A.5e.1 | |||||||||
Y55D5A.5f.1 | |||||||||
Y55D5A.5g.1 | |||||||||
Other_sequence (112) | |||||||||
Associated_feature (24) | |||||||||
Experimental_info (11) | |||||||||
Map_info | Map | III | Position | -8.03413 | Error | 0.111365 | |||
Well_ordered | |||||||||
Positive | Inside_rearr | nDf11 | |||||||
Positive_clone | C44B11 | ||||||||
H05C05 | |||||||||
Y55D5A | Inferred_automatically | From sequence, transcript, pseudogene data | |||||||
Negative | Outside_rearr | tDf9 | |||||||
Mapping_data | 2_point | 273 | |||||||
411 | |||||||||
412 | |||||||||
7053 | |||||||||
Multi_point (23) | |||||||||
Pos_neg_data (12) | |||||||||
Reference (1726) | |||||||||
Picture | WBPicture0000013078 | ||||||||
WBPicture0000013087 | |||||||||
Method | Gene |