WormBase Tree Display for Gene: WBGene00000899
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| WBGene00000899 | SMap | S_parent | Sequence | F25E2 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | daf-3 | Person_evidence | WBPerson521 | |||||
| Sequence_name | F25E2.5 | ||||||||
| Molecular_name (27) | |||||||||
| Other_name | CELE_F25E2.5 | Accession_evidence | NDB | BX284606 | |||||
| Public_name | daf-3 | ||||||||
| DB_info | Database | AceView | gene | XB438 | |||||
| WormQTL | gene | WBGene00000899 | |||||||
| SignaLink | protein | WBGene00000899 | |||||||
| WormFlux | gene | WBGene00000899 | |||||||
| NDB | locus_tag | CELE_F25E2.5 | |||||||
| Panther | gene | CAEEL|WormBase=F25E2.5d|UniProtKB=A0A0K3AVK9 | |||||||
| family | PTHR13703 | ||||||||
| NCBI | gene | 180431 | |||||||
| RefSeq | protein | NM_001313413.4 | |||||||
| NM_001313414.4 | |||||||||
| NM_001029434.5 | |||||||||
| NM_001313417.4 | |||||||||
| NM_075760.6 | |||||||||
| NM_001029433.7 | |||||||||
| NM_001313412.4 | |||||||||
| NM_001380898.1 | |||||||||
| NM_001313415.4 | |||||||||
| SwissProt | UniProtAcc | Q95QI7 | |||||||
| UniProt_GCRP | UniProtAcc | Q95QI7 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:21 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | daf | ||||||||
| Reference_allele | WBVar00143953 | ||||||||
| Allele (178) | |||||||||
| Legacy_information | e1376 : defective dauer formation (daf-2 suppressible). ES1 ME3 NA8. | ||||||||
| See also e1376 | |||||||||
| [C.elegansII] e1376 : defective dauer formation. ES1 ME3. OA7. [Riddle et al. 1981; Thomas et al. 1993; DR] | |||||||||
| Strain (14) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (36) | |||||||||
| Ortholog (26) | |||||||||
| Paralog | WBGene00004857 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
| WormBase-Compara | |||||||||
| WBGene00004856 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| WormBase-Compara | |||||||||
| WBGene00000904 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| WormBase-Compara | |||||||||
| WBGene00000910 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| WormBase-Compara | |||||||||
| WBGene00004858 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00006445 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| Structured_description | Concise_description | daf-3 encodes a co-SMAD protein that is most closely related to Drosophila Medea and the vertebrate Smad4 proteins; DAF-3 functions as a transcriptional regulator that is required for formation of the alternative dauer larval stage as well as for regulation of pharyngeal gene expression during non-dauer development, and normal adult lifespan; DAF-3 activity is antagonized by signaling through the DAF-7/TGF-beta pathway which promotes reproductive growth; in yeast two-hybrid studies, DAF-3 interacts with SMA-3, another Smad protein that does not appear to have a role in dauer formation; in vitro, DAF-3 binds the organ-specific C subelement in the promoter of the pharyngeal muscle-specific myosin myo-2 and in vivo, suppresses the enhancer activity of this element during larval development; a DAF-3::GFP fusion protein is expressed in many tissues that undergo remodeling during dauer development, including the gut, nervous system and pharynx; DAF-3 localizes predominantly to the cytoplasm, but is also found in the nucleus in association with mitotic chromosomes. | Paper_evidence | WBPaper00002915 | |||||
| WBPaper00003384 | |||||||||
| WBPaper00006332 | |||||||||
| WBPaper00031040 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 10 Apr 2017 00:00:00 | ||||||||
| Automated_description | Enables cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including determination of adult lifespan; positive regulation of dauer larval development; and regulation of pharyngeal pumping. Located in condensed chromosome; cytoplasm; and nucleus. Expressed in several structures, including P1; P2; hermaphrodite distal tip cell; hypodermal cell; and neurons. | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | F25E2.5a | |||||||
| F25E2.5b | |||||||||
| F25E2.5c | |||||||||
| F25E2.5d | |||||||||
| F25E2.5e | |||||||||
| F25E2.5f | |||||||||
| F25E2.5g | |||||||||
| F25E2.5h | |||||||||
| F25E2.5i | |||||||||
| Corresponding_transcript | F25E2.5a.1 | ||||||||
| F25E2.5b.1 | |||||||||
| F25E2.5c.1 | |||||||||
| F25E2.5d.1 | |||||||||
| F25E2.5e.1 | |||||||||
| F25E2.5f.1 | |||||||||
| F25E2.5g.1 | |||||||||
| F25E2.5h.1 | |||||||||
| F25E2.5i.1 | |||||||||
| Other_sequence | CBC08439_1 | ||||||||
| Associated_feature | WBsf653668 | ||||||||
| WBsf669931 | |||||||||
| WBsf670084 | |||||||||
| WBsf978813 | |||||||||
| WBsf1003871 | |||||||||
| WBsf1003872 | |||||||||
| WBsf1022176 | |||||||||
| WBsf236964 | |||||||||
| WBsf236965 | |||||||||
| Gene_product_binds | WBsf919607 | ||||||||
| WBsf919641 | |||||||||
| Transcription_factor | WBTranscriptionFactor000472 | ||||||||
| Experimental_info (11) | |||||||||
| Map_info | Map | X | Position | -19.4994 | Error | 0.004628 | |||
| Well_ordered | |||||||||
| Positive | Inside_rearr | mgDf90 | |||||||
| Positive_clone | F25E2 | Inferred_automatically | From sequence, transcript, pseudogene data | ||||||
| Mapping_data | 2_point | 299 | |||||||
| 413 | |||||||||
| 414 | |||||||||
| Multi_point | 5067 | ||||||||
| Pos_neg_data | 9317 | ||||||||
| Reference (225) | |||||||||
| Method | Gene |
