WormBase Tree Display for Gene: WBGene00000910
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| WBGene00000910 | Evidence | CGC_data_submission | |||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | F01G10 | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | daf-14 | Person_evidence | WBPerson521 | |||||
| Sequence_name | F01G10.8 | ||||||||
| Molecular_name | F01G10.8a | ||||||||
| F01G10.8a.1 | |||||||||
| CE29090 | |||||||||
| F01G10.8b | |||||||||
| CE45907 | |||||||||
| F01G10.8b.1 | |||||||||
| Other_name | CELE_F01G10.8 | Accession_evidence | NDB | BX284604 | |||||
| Public_name | daf-14 | ||||||||
| DB_info | Database | AceView | gene | 4L19 | |||||
| WormQTL | gene | WBGene00000910 | |||||||
| WormFlux | gene | WBGene00000910 | |||||||
| NDB | locus_tag | CELE_F01G10.8 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00000910|UniProtKB=F5GUE5 | |||||||
| family | PTHR13703 | ||||||||
| NCBI | gene | 177908 | |||||||
| RefSeq | protein | NM_001268547.2 | |||||||
| NM_001268546.3 | |||||||||
| SwissProt | UniProtAcc | F5GUE5 | |||||||
| UniProt_GCRP | UniProtAcc | F5GUE5 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:21 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | daf | ||||||||
| Reference_allele | WBVar00088567 | ||||||||
| Allele (71) | |||||||||
| Legacy_information | m77ts : constitutive dauer formation at 25x incomplete penetrance reversible by shift to 15x; Type C Egl. ES3 (L3). NA1. | ||||||||
| [C.elegansII] m77ts : constitutive dauer formation at 25C, incomplete penetrance, reversible by shift to 15C; Type C Egl; dark intestine; clumpy; Srf-6 at 16C. ES3 (L3). OA1: sa340 (21% dauers at 25C, derived from egl-21 strain).Cloned: cosmid rescue. [Thomas et al. 1994; DR; GR; JT] | |||||||||
| Strain | WBStrain00022477 | ||||||||
| WBStrain00022842 | |||||||||
| WBStrain00030740 | |||||||||
| WBStrain00030759 | |||||||||
| WBStrain00033294 | |||||||||
| WBStrain00006222 | |||||||||
| WBStrain00006223 | |||||||||
| WBStrain00006237 | |||||||||
| WBStrain00006267 | |||||||||
| WBStrain00006177 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (28) | |||||||||
| Ortholog (24) | |||||||||
| Paralog | WBGene00000899 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
| WormBase-Compara | |||||||||
| WBGene00000904 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00004857 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00004856 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00004858 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00006445 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | daf-14 encodes a Smad-related protein that is unusual in that while its C-terminus is well-conserved with Smad proteins, it lacks the N-terminal DNA binding domain found in all other known Smads; DAF-14 is predicted to function as a transducer of the DAF-7/TGF-beta-mediated signal that promotes reproductive growth and negatively regulates dauer formation; DAF-14 activity is also required for normal adult lifespan; as reduction of daf-14 function enhances the dauer constitutive phenotype of daf-8 mutants, and overexpression of daf-14 can rescue daf-8 mutant animals, it is likely that the DAF-14 and DAF-8 Smad proteins function in parallel to control dauer formation; further genetic analyses suggest that DAF-14 and DAF-8 function to antagonize the activities of the DAF-3 Smad and DAF-5 Sno/Ski oncoprotein, which are required for dauer formation; a DAF-14::GFP reporter is expressed in a dynamic pattern in tissues, such as the hypodermis, intestine, and pharynx, that are remodeled during dauer development. | Paper_evidence | WBPaper00002915 | |||||
| WBPaper00003883 | |||||||||
| WBPaper00006391 | |||||||||
| WBPaper00031040 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 10 Apr 2017 00:00:00 | ||||||||
| Automated_description | Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; I-SMAD binding activity; and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including determination of adult lifespan; egg-laying behavior; and negative regulation of dauer larval development. Predicted to be part of heteromeric SMAD protein complex. Expressed in several structures, including anal sphincter muscle; excretory duct cell; intestine; nerve ring; and phasmid sheath cell. | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | F01G10.8a | |||||||
| F01G10.8b | |||||||||
| Corresponding_CDS_history | F01G10.8:wp52 | ||||||||
| F01G10.8:wp63 | |||||||||
| Corresponding_transcript | F01G10.8a.1 | ||||||||
| F01G10.8b.1 | |||||||||
| Other_sequence (12) | |||||||||
| Associated_feature | WBsf228969 | ||||||||
| Transcription_factor | WBTranscriptionFactor000351 | ||||||||
| Experimental_info | RNAi_result | WBRNAi00012750 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00030554 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00043770 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00067623 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00075919 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr967 | ||||||||
| Expr1022498 | |||||||||
| Expr1030571 | |||||||||
| Expr1147748 | |||||||||
| Expr2010763 | |||||||||
| Expr2029000 | |||||||||
| Drives_construct | WBCnstr00001991 | ||||||||
| WBCnstr00001995 | |||||||||
| WBCnstr00019738 | |||||||||
| WBCnstr00037201 | |||||||||
| Construct_product | WBCnstr00001991 | ||||||||
| WBCnstr00037201 | |||||||||
| Microarray_results (22) | |||||||||
| Expression_cluster (128) | |||||||||
| Interaction (128) | |||||||||
| WBProcess | WBbiopr:00000025 | ||||||||
| Map_info | Map | IV | Position | 4.56437 | |||||
| Positive | Positive_clone | F01G10 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | 2_point | 436 | |||||||
| 437 | |||||||||
| Multi_point (17) | |||||||||
| Pos_neg_data | 957 | ||||||||
| 965 | |||||||||
| 2738 | |||||||||
| Reference (138) | |||||||||
| Remark | Sequence connection from [Inoue T, Thomas JH] | ||||||||
| Method | Gene |
