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WormBase Tree Display for Gene: WBGene00000962

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Name Class

WBGene00000962EvidenceCGC_data_submission
SMapS_parentSequenceT21E12
IdentityVersion1
NameCGC_namedhc-1Person_evidenceWBPerson1562
Sequence_nameT21E12.4
Molecular_nameT21E12.4a
T21E12.4a.1
CE23997
T21E12.4b
CE51690
T21E12.4b.1
Other_namelet-354
spd-4
CELE_T21E12.4Accession_evidenceNDBBX284601
Public_namedhc-1
DB_infoDatabase (11)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:22WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_info (13)
Disease_infoExperimental_modelDOID:1826Homo sapiensPaper_evidenceWBPaper00028525
Curator_confirmedWBPerson324
Date_last_updated24 Aug 2021 00:00:00
DOID:0050453Homo sapiensPaper_evidenceWBPaper00028525
Accession_evidenceOMIM607432
Curator_confirmedWBPerson324
Date_last_updated17 Apr 2013 00:00:00
Potential_modelDOID:0070043Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:2961)
DOID:10652Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:2961)
DOID:0070351Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:2961)
DOID:0110175Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:2961)
Disease_relevanceIn humans, mutations in the LIS1 gene (Platelet activating factor acetylhydrolase, isoform 1B, alpha subunit; PAFAH1B1) and the LIS1 pathway, are implicated in Lissencephaly, a developmental abnormality associated with a failure of neuronal migration in the cerebral cortex, leading to mental retardation and epilepsy; human NDE1 and NDEL1, are effectors of LIS1; the elegans genetic model for epileptic siezures consists of lis-1 mutants that are responsive to the common seizure inducer pentylenetetrazole (PTZ) and diplay a distinct convulsive phenotype; studies in the worm show that dhc-1/dynein heavy chain (orthologous to human DYNC1H1), is a LIS1 pathway component and worms depleted for LIS1 pathway components via RNA interference, NUD-1, NUD-2, DHC-1, CDK-5, and CDKA-1, also exhibited significant convulsions following PTZ treatment; further nud-1 (orthologous to human NUDC), nud-2/NDE1 and cdk-5 show significant enhancement in convulsions in a lis-1 heterozygous background when compared with the wild-type background; these animals are also less likely to recover when PTZ treatment is removed, when compared to wild-type; these studies show that while knocking down target genes (lis-1, cdk-5, and cdka-1 that function in neuronal migration), and their interacting proteins like nud-1, nud-2 and dhc-1, does not yield spontaneous convulsions in C. elegans, further alterations in the neural environment through the application of PTZ serve to pass a critical threshold within these animals.Homo sapiensCurator_confirmedWBPerson324
Models_disease_in_annotationWBDOannot00000150
WBDOannot00001012
Molecular_infoCorresponding_CDST21E12.4a
T21E12.4b
Corresponding_transcriptT21E12.4a.1
T21E12.4b.1
Other_sequence (122)
Associated_featureWBsf643215
WBsf656205
WBsf656206
WBsf656207
WBsf656208
WBsf983394
WBsf217528
WBsf217529
Experimental_infoRNAi_result (43)
Expr_pattern (19)
Drives_constructWBCnstr00003093
WBCnstr00007434
WBCnstr00008880
WBCnstr00013402
WBCnstr00037176
WBCnstr00042469
Construct_productWBCnstr00007434
WBCnstr00008880
WBCnstr00013402
WBCnstr00037176
WBCnstr00039347
WBCnstr00042469
AntibodyWBAntibody00000242
WBAntibody00000917
WBAntibody00002792
WBAntibody00002860
Microarray_results (20)
Expression_cluster (137)
InteractionWBInteraction000001876
WBInteraction000001996
WBInteraction000002423
WBInteraction000002424
WBInteraction000002425
WBInteraction000004815
WBInteraction000008081
WBInteraction000008082
WBInteraction000008083
WBInteraction000008086
WBInteraction000008087
WBInteraction000008088
WBInteraction000008089
WBInteraction000008090
WBInteraction000008091
WBInteraction000008093
WBInteraction000008094
WBInteraction000008095
WBInteraction000008098
WBInteraction000008099
WBInteraction000008100
WBInteraction000008102
WBInteraction000008103
WBInteraction000008104
WBInteraction000008107
WBInteraction000008108
WBInteraction000008109
WBInteraction000008110
WBInteraction000008111
WBInteraction000008112
WBInteraction000008113
WBInteraction000008114
WBInteraction000008115
WBInteraction000008116
WBInteraction000008117
WBInteraction000008118
WBInteraction000008121
WBInteraction000008122
WBInteraction000008123
WBInteraction000008125
WBInteraction000008126
WBInteraction000008127
WBInteraction000008129
WBInteraction000008130
WBInteraction000008131
WBInteraction000008133
WBInteraction000008134
WBInteraction000008135
WBInteraction000008137
WBInteraction000008138
WBInteraction000008139
WBInteraction000008141
WBInteraction000008142
WBInteraction000008143
WBInteraction000008145
WBInteraction000008146
WBInteraction000008147
WBInteraction000008150
WBInteraction000008151
WBInteraction000008152
WBInteraction000008153
WBInteraction000008154
WBInteraction000008156
WBInteraction000008157
WBInteraction000008159
WBInteraction000008160
WBInteraction000008161
WBInteraction000008164
WBInteraction000008165
WBInteraction000008166
WBInteraction000008168
WBInteraction000008169
WBInteraction000008170
WBInteraction000008172
WBInteraction000008173
WBInteraction000008174
WBInteraction000008175
WBInteraction000008176
WBInteraction000008177
WBInteraction000008179
WBInteraction000008180
WBInteraction000008181
WBInteraction000008182
WBInteraction000008183
WBInteraction000008184
WBInteraction000008186
WBInteraction000008187
WBInteraction000008188
WBInteraction000008189
WBInteraction000008190
WBInteraction000008191
WBInteraction000008193
WBInteraction000008194
WBInteraction000008195
WBInteraction000008196
WBInteraction000008197
WBInteraction000008198
WBInteraction000008199
WBInteraction000008200
WBInteraction000008201
WBInteraction000008202
WBInteraction000008203
WBInteraction000008204
WBInteraction000008205
WBInteraction000008206
WBInteraction000008207
WBInteraction000008208
WBInteraction000008209
WBInteraction000008210
WBInteraction000008212
WBInteraction000008213
WBInteraction000008214
WBInteraction000008215
WBInteraction000008216
WBInteraction000008217
WBInteraction000008218
WBInteraction000008219
WBInteraction000008220
WBInteraction000008221
WBInteraction000008222
WBInteraction000008223
WBInteraction000008224
WBInteraction000008225
WBInteraction000008226
WBInteraction000008227
WBInteraction000008228
WBInteraction000008229
WBInteraction000008230
WBInteraction000008231
WBInteraction000008233
WBInteraction000008234
WBInteraction000008235
WBInteraction000008236
WBInteraction000008238
WBInteraction000008239
WBInteraction000008240
WBInteraction000008241
WBInteraction000008242
WBInteraction000008243
WBInteraction000008244
WBInteraction000008246
WBInteraction000008247
WBInteraction000008248
WBInteraction000008249
WBInteraction000008250
WBInteraction000008251
WBInteraction000008252
WBInteraction000008253
WBInteraction000008254
WBInteraction000008255
WBInteraction000008256
WBInteraction000008257
WBInteraction000008258
WBInteraction000008259
WBInteraction000008260
WBInteraction000009918
WBInteraction000028422
WBInteraction000028592
WBInteraction000028593
WBInteraction000028700
WBInteraction000028877
WBInteraction000032726
WBInteraction000032781
WBInteraction000032907
WBInteraction000033151
WBInteraction000033291
WBInteraction000033416
WBInteraction000034099
WBInteraction000034262
WBInteraction000034334
WBInteraction000034477
WBInteraction000034646
WBInteraction000035087
WBInteraction000035348
WBInteraction000035534
WBInteraction000036073
WBInteraction000036562
WBInteraction000037202
WBInteraction000037832
WBInteraction000038279
WBInteraction000038402
WBInteraction000038490
WBInteraction000039010
WBInteraction000039170
WBInteraction000039214
WBInteraction000039741
WBInteraction000039776
WBInteraction000041738
WBInteraction000042118
WBInteraction000043482
WBInteraction000045581
WBInteraction000046376
WBInteraction000046380
WBInteraction000048446
WBInteraction000049498
WBInteraction000049868
WBInteraction000050052
WBInteraction000050484
WBInteraction000050536
WBInteraction000050756
WBInteraction000050926
WBInteraction000052762
WBInteraction000052763
WBInteraction000112991
WBInteraction000120236
WBInteraction000137967
WBInteraction000137968
WBInteraction000139201
WBInteraction000140872
WBInteraction000151419
WBInteraction000152078
WBInteraction000153027
WBInteraction000166278
WBInteraction000166279
WBInteraction000166479
WBInteraction000166622
WBInteraction000208266
WBInteraction000211658
WBInteraction000225867
WBInteraction000236114
WBInteraction000240180
WBInteraction000240508
WBInteraction000247216
WBInteraction000250985
WBInteraction000258511
WBInteraction000261848
WBInteraction000269179
WBInteraction000271449
WBInteraction000296195
WBInteraction000303857
WBInteraction000313138
WBInteraction000314912
WBInteraction000324492
WBInteraction000331232
WBInteraction000334151
WBInteraction000342867
WBInteraction000346649
WBInteraction000351396
WBInteraction000359871
WBInteraction000368735
WBInteraction000382794
WBInteraction000393677
WBInteraction000399084
WBInteraction000401916
WBInteraction000402779
WBInteraction000420188
WBInteraction000421080
WBInteraction000423128
WBInteraction000424628
WBInteraction000426485
WBInteraction000427834
WBInteraction000431683
WBInteraction000442879
WBInteraction000457892
WBInteraction000460869
WBInteraction000468806
WBInteraction000470584
WBInteraction000471909
WBInteraction000471983
WBInteraction000472043
WBInteraction000472523
WBInteraction000501988
WBInteraction000501989
WBInteraction000502995
WBInteraction000502996
WBInteraction000503345
WBInteraction000503346
WBInteraction000503347
WBInteraction000503960
WBInteraction000503961
WBInteraction000504693
WBInteraction000504720
WBInteraction000522714
WBInteraction000540068
WBInteraction000540069
WBInteraction000540488
WBInteraction000540630
WBInteraction000540631
WBInteraction000549426
WBInteraction000555762
WBInteraction000555767
WBInteraction000557070
WBInteraction000563072
WBInteraction000568899
WBInteraction000569109
WBInteraction000569282
WBInteraction000570280
WBInteraction000571871
WBInteraction000574665
WBInteraction000578533
WBInteraction000582834
WBInteraction000586397
WBProcessWBbiopr:00000017
Map_infoMapIPosition-1.31043Error0.007943
Well_ordered
PositivePositive_cloneT21E12Inferred_automaticallyFrom sequence, transcript, pseudogene data
Mapping_data2_point2523
Multi_point1007
1758
1759
1760
1761
1762
1763
3862
Pos_neg_data (15)
Reference (130)
RemarkSequence connection from [Schmidt D, Strome S]
Previous connection of genomic_sequence to dhc-14 was a typo [030225 ck1]
MethodGene