WormBase Tree Display for Gene: WBGene00000962
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WBGene00000962 | Evidence | CGC_data_submission | |||||||
---|---|---|---|---|---|---|---|---|---|
SMap | S_parent | Sequence | T21E12 | ||||||
Identity | Version | 1 | |||||||
Name | CGC_name | dhc-1 | Person_evidence | WBPerson1562 | |||||
Sequence_name | T21E12.4 | ||||||||
Molecular_name | T21E12.4a | ||||||||
T21E12.4a.1 | |||||||||
CE23997 | |||||||||
T21E12.4b | |||||||||
CE51690 | |||||||||
T21E12.4b.1 | |||||||||
Other_name | let-354 | ||||||||
spd-4 | |||||||||
CELE_T21E12.4 | Accession_evidence | NDB | BX284601 | ||||||
Public_name | dhc-1 | ||||||||
DB_info | Database (11) | ||||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 07 Apr 2004 11:29:22 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
Status | Live | ||||||||
Gene_info (13) | |||||||||
Disease_info | Experimental_model | DOID:1826 | Homo sapiens | Paper_evidence | WBPaper00028525 | ||||
Curator_confirmed | WBPerson324 | ||||||||
Date_last_updated | 24 Aug 2021 00:00:00 | ||||||||
DOID:0050453 | Homo sapiens | Paper_evidence | WBPaper00028525 | ||||||
Accession_evidence | OMIM | 607432 | |||||||
Curator_confirmed | WBPerson324 | ||||||||
Date_last_updated | 17 Apr 2013 00:00:00 | ||||||||
Potential_model | DOID:0070043 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2961) | |||||
DOID:10652 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2961) | ||||||
DOID:0070351 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2961) | ||||||
DOID:0110175 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2961) | ||||||
Disease_relevance | In humans, mutations in the LIS1 gene (Platelet activating factor acetylhydrolase, isoform 1B, alpha subunit; PAFAH1B1) and the LIS1 pathway, are implicated in Lissencephaly, a developmental abnormality associated with a failure of neuronal migration in the cerebral cortex, leading to mental retardation and epilepsy; human NDE1 and NDEL1, are effectors of LIS1; the elegans genetic model for epileptic siezures consists of lis-1 mutants that are responsive to the common seizure inducer pentylenetetrazole (PTZ) and diplay a distinct convulsive phenotype; studies in the worm show that dhc-1/dynein heavy chain (orthologous to human DYNC1H1), is a LIS1 pathway component and worms depleted for LIS1 pathway components via RNA interference, NUD-1, NUD-2, DHC-1, CDK-5, and CDKA-1, also exhibited significant convulsions following PTZ treatment; further nud-1 (orthologous to human NUDC), nud-2/NDE1 and cdk-5 show significant enhancement in convulsions in a lis-1 heterozygous background when compared with the wild-type background; these animals are also less likely to recover when PTZ treatment is removed, when compared to wild-type; these studies show that while knocking down target genes (lis-1, cdk-5, and cdka-1 that function in neuronal migration), and their interacting proteins like nud-1, nud-2 and dhc-1, does not yield spontaneous convulsions in C. elegans, further alterations in the neural environment through the application of PTZ serve to pass a critical threshold within these animals. | Homo sapiens | Curator_confirmed | WBPerson324 | |||||
Models_disease_in_annotation | WBDOannot00000150 | ||||||||
WBDOannot00001012 | |||||||||
Molecular_info | Corresponding_CDS | T21E12.4a | |||||||
T21E12.4b | |||||||||
Corresponding_transcript | T21E12.4a.1 | ||||||||
T21E12.4b.1 | |||||||||
Other_sequence | MI05328 | ||||||||
HG09483 | |||||||||
CR06938 | |||||||||
SR04717 | |||||||||
EY473357.1 | |||||||||
HGC05288_1 | |||||||||
HG04602 | |||||||||
Tcol_isotig01501 | |||||||||
ACC31961_1 | |||||||||
FC541563.1 | |||||||||
FC547166.1 | |||||||||
HGC11537_1 | |||||||||
CR04675 | |||||||||
CR03857 | |||||||||
FD514573.1 | |||||||||
Acan_isotig01643 | |||||||||
Dviv_isotig23127 | |||||||||
HG04398 | |||||||||
EX554095.1 | |||||||||
CBC10492_1 | |||||||||
EY460757.1 | |||||||||
ACC29450_1 | |||||||||
AF345794.1 | |||||||||
HGC12145_1 | |||||||||
HS01156 | |||||||||
EY465485.1 | |||||||||
ASC04257_1 | |||||||||
FC542230.1 | |||||||||
JI462358.1 | |||||||||
HGC11240_1 | |||||||||
CRC10764_1 | |||||||||
CRC00967_1 | |||||||||
EX549147.1 | |||||||||
EX552788.1 | |||||||||
Tcol_isotig01499 | |||||||||
CBC07849_1 | |||||||||
JI466643.1 | |||||||||
MA02017 | |||||||||
JI469556.1 | |||||||||
RSC00485_1 | |||||||||
HSC01511_1 | |||||||||
JI466703.1 | |||||||||
Tcol_isotig18307 | |||||||||
Name_isotig05541 | |||||||||
Tcir_isotig15105 | |||||||||
ACC09510_1 | |||||||||
EX545222.1 | |||||||||
JI473892.1 | |||||||||
CSC01077_1 | |||||||||
Acan_isotig23031 | |||||||||
BUC01617_1 | |||||||||
Oden_isotig13546 | |||||||||
Hbac_isotig04221 | |||||||||
FC819864.1 | |||||||||
FC546244.1 | |||||||||
CRC03983_1 | |||||||||
HG04631 | |||||||||
CBC01865_1 | |||||||||
EX552977.1 | |||||||||
Acan_isotig01642 | |||||||||
BXC07207_1 | |||||||||
EX559338.1 | |||||||||
CK854663.1 | |||||||||
EY462170.1 | |||||||||
Tcol_isotig01500 | |||||||||
EX557334.1 | |||||||||
CRC12256_1 | |||||||||
FC810952.1 | |||||||||
EY470294.1 | |||||||||
EX548381.1 | |||||||||
HC03110 | |||||||||
CJC09629_1 | |||||||||
JI459625.1 | |||||||||
JI163783.1 | |||||||||
FM207803.1 | |||||||||
FC545746.1 | |||||||||
FC544967.1 | |||||||||
FC817987.1 | |||||||||
CR07864 | |||||||||
Dviv_isotig25064 | |||||||||
EX548746.1 | |||||||||
TDC01437_1 | |||||||||
SRC03452_1 | |||||||||
HC04485 | |||||||||
BXC05721_1 | |||||||||
MJ04647 | |||||||||
MJC03793_1 | |||||||||
MAC01346_1 | |||||||||
Tcir_isotig05652 | |||||||||
FC546814.1 | |||||||||
JI459579.1 | |||||||||
Acan_isotig01644 | |||||||||
EX538063.1 | |||||||||
Oden_isotig13545 | |||||||||
HS00094 | |||||||||
HCC01244_1 | |||||||||
HG05231 | |||||||||
Tcol_isotig01502 | |||||||||
EY473347.1 | |||||||||
EX550223.1 | |||||||||
EY465318.1 | |||||||||
CRC03947_1 | |||||||||
EX547627.1 | |||||||||
MIC04661_1 | |||||||||
EY462088.1 | |||||||||
WBC02134_1 | |||||||||
HSC00228_1 | |||||||||
CR04119 | |||||||||
BXC07559_1 | |||||||||
FC816412.1 | |||||||||
Name_isotig05777 | |||||||||
EX555097.1 | |||||||||
AS10298 | |||||||||
EX559803.1 | |||||||||
SRC00785_1 | |||||||||
GT737140.1 | |||||||||
CB037474.1 | |||||||||
HCC09529_1 | |||||||||
Hbac_isotig06346 | |||||||||
FC547729.1 | |||||||||
SR00190 | |||||||||
JI473733.1 | |||||||||
Associated_feature | WBsf643215 | ||||||||
WBsf656205 | |||||||||
WBsf656206 | |||||||||
WBsf656207 | |||||||||
WBsf656208 | |||||||||
WBsf983394 | |||||||||
WBsf217528 | |||||||||
WBsf217529 | |||||||||
Experimental_info | RNAi_result (43) | ||||||||
Expr_pattern (19) | |||||||||
Drives_construct | WBCnstr00003093 | ||||||||
WBCnstr00007434 | |||||||||
WBCnstr00008880 | |||||||||
WBCnstr00013402 | |||||||||
WBCnstr00037176 | |||||||||
WBCnstr00042469 | |||||||||
Construct_product | WBCnstr00007434 | ||||||||
WBCnstr00008880 | |||||||||
WBCnstr00013402 | |||||||||
WBCnstr00037176 | |||||||||
WBCnstr00039347 | |||||||||
WBCnstr00042469 | |||||||||
Antibody | WBAntibody00000242 | ||||||||
WBAntibody00000917 | |||||||||
WBAntibody00002792 | |||||||||
WBAntibody00002860 | |||||||||
Microarray_results (20) | |||||||||
Expression_cluster (137) | |||||||||
Interaction (292) | |||||||||
WBProcess | WBbiopr:00000017 | ||||||||
Map_info | Map | I | Position | -1.31043 | Error | 0.007943 | |||
Well_ordered | |||||||||
Positive | Positive_clone | T21E12 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
Mapping_data | 2_point | 2523 | |||||||
Multi_point | 1007 | ||||||||
1758 | |||||||||
1759 | |||||||||
1760 | |||||||||
1761 | |||||||||
1762 | |||||||||
1763 | |||||||||
3862 | |||||||||
Pos_neg_data (15) | |||||||||
Reference (130) | |||||||||
Remark | Sequence connection from [Schmidt D, Strome S] | ||||||||
Previous connection of genomic_sequence to dhc-14 was a typo [030225 ck1] | |||||||||
Method | Gene |