WormBase Tree Display for Gene: WBGene00001049
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| WBGene00001049 | SMap | S_parent | Sequence | F33H2 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | dog-1 | Person_evidence | WBPerson533 | |||||
| Sequence_name | F33H2.1 | ||||||||
| Molecular_name | F33H2.1 | ||||||||
| F33H2.1.1 | |||||||||
| CE17764 | |||||||||
| Other_name | CELE_F33H2.1 | Accession_evidence | NDB | BX284601 | |||||
| Public_name | dog-1 | ||||||||
| DB_info | Database (13) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:22 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | dog | ||||||||
| Allele (117) | |||||||||
| Strain | WBStrain00001778 | ||||||||
| WBStrain00003477 | |||||||||
| WBStrain00035483 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (25) | |||||||||
| Contained_in_operon | CEOP1772 | ||||||||
| Ortholog (43) | |||||||||
| Paralog | WBGene00010839 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| WBGene00009124 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00044493 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WBGene00021752 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | dog-1 encodes a helicase homologous to the human FANCJ/BRIP1/BACH1 helicase; DOG-1 is required for interstrand cross-link (ICL) repair and for maintenance of polyguanine tracts of germline and somatic DNA by resolving the secondary structure that can occur in guanine-rich DNA during lagging-strand DNA synthesis; genetic analysis suggests that dog-1 functions downstream of fcd-2 and rad-51 in mediating ICL and that fcd-2 activity is required for G/C tract maintenance in the absence of dog-1. | Paper_evidence | WBPaper00005308 | |||||
| WBPaper00031336 | |||||||||
| Curator_confirmed | WBPerson48 | ||||||||
| WBPerson1843 | |||||||||
| WBPerson1823 | |||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 25 May 2011 00:00:00 | ||||||||
| Automated_description | Predicted to enable DNA helicase activity. Involved in DNA metabolic process; regulation of DNA-templated DNA replication; and reproduction. Predicted to be located in nucleus. Expressed in head and tail. Used to study Fanconi anemia. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; Down syndrome; Fanconi anemia complementation group J; and cervical squamous cell carcinoma. Is an ortholog of human BRIP1 (BRCA1 interacting helicase 1). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:13636 | Homo sapiens | Paper_evidence | WBPaper00031336 | ||||
| Accession_evidence | OMIM | 227650 | |||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 05 Mar 2018 00:00:00 | ||||||||
| Potential_model | DOID:10652 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:20473) | |||||
| DOID:9256 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:20473) | ||||||
| DOID:14250 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:20473) | ||||||
| DOID:3459 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:20473) | ||||||
| DOID:3744 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:20473) | ||||||
| DOID:1588 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:20473) | ||||||
| DOID:1612 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:20473) | ||||||
| DOID:0111097 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:20473) | ||||||
| Disease_relevance | Human FANCJ/BRIP1/BACH1 encodes a dead-box helicase and BRCA1-binding protein mutated in Fanconi anemia (FA) and early-onset breast cancer; Fanconi anemia is a disorder characterized by genomic instability and cellular hypersensitivity to chemicals that generate DNA interstrand cross-links (ICLs); studies in C.elegans indicate that dog-1, the C. elegans functional orthlog of FANCJ, functions to maintain G-rich DNA and reduce ICL-induced damage, together with other FA pathway components. | Homo sapiens | Paper_evidence | WBPaper00041180 | |||||
| Curator_confirmed | WBPerson324 | ||||||||
| Models_disease_asserted | WBDOannot00000099 | ||||||||
| WBDOannot00000493 | |||||||||
| WBDOannot00000494 | |||||||||
| Molecular_info | Corresponding_CDS | F33H2.1 | |||||||
| Corresponding_transcript | F33H2.1.1 | ||||||||
| Other_sequence (23) | |||||||||
| Associated_feature | WBsf649787 | ||||||||
| WBsf665194 | |||||||||
| WBsf220678 | |||||||||
| Experimental_info | RNAi_result (11) | ||||||||
| Expr_pattern | Chronogram442 | ||||||||
| Chronogram788 | |||||||||
| Expr5942 | |||||||||
| Expr5943 | |||||||||
| Expr1021031 | |||||||||
| Expr1030661 | |||||||||
| Expr1150126 | |||||||||
| Expr2011023 | |||||||||
| Expr2029260 | |||||||||
| Drives_construct | WBCnstr00002591 | ||||||||
| WBCnstr00004379 | |||||||||
| WBCnstr00037121 | |||||||||
| Construct_product | WBCnstr00037121 | ||||||||
| Microarray_results (19) | |||||||||
| Expression_cluster (140) | |||||||||
| Interaction | WBInteraction000052805 | ||||||||
| WBInteraction000052900 | |||||||||
| WBInteraction000161806 | |||||||||
| WBInteraction000161819 | |||||||||
| WBInteraction000163067 | |||||||||
| WBInteraction000351166 | |||||||||
| WBInteraction000372486 | |||||||||
| WBInteraction000441914 | |||||||||
| WBInteraction000500003 | |||||||||
| WBInteraction000500004 | |||||||||
| Map_info | Map | I | Position | 29.4332 | Error | 0.084094 | |||
| Positive | Positive_clone | F33H2 | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Mapping_data | Multi_point | 4499 | |||||||
| Pseudo_map_position | |||||||||
| Reference (50) | |||||||||
| Remark | Sequence connection from [Cheung I, Schertzer M, Rose A, Lansdorp RM], [020809 krb] | ||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
