dog-1 encodes a helicase homologous to the human FANCJ/BRIP1/BACH1 helicase; DOG-1 is required for interstrand cross-link (ICL) repair and for maintenance of polyguanine tracts of germline and somatic DNA by resolving the secondary structure that can occur in guanine-rich DNA during lagging-strand DNA synthesis; genetic analysis suggests that dog-1 functions downstream of fcd-2 and rad-51 in mediating ICL and that fcd-2 activity is required for G/C tract maintenance in the absence of dog-1.
Predicted to enable DNA helicase activity. Involved in DNA metabolic process; regulation of DNA-templated DNA replication; and reproduction. Predicted to be located in nucleus. Expressed in head and tail. Used to study Fanconi anemia. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; Down syndrome; Fanconi anemia complementation group J; and cervical squamous cell carcinoma. Is an ortholog of human BRIP1 (BRCA1 interacting helicase 1).
Inferred by orthology to human genes with DO annotation (HGNC:20473)
Disease_relevance
Human FANCJ/BRIP1/BACH1 encodes a dead-box helicase and BRCA1-binding protein mutated in Fanconi anemia (FA) and early-onset breast cancer; Fanconi anemia is a disorder characterized by genomic instability and cellular hypersensitivity to chemicals that generate DNA interstrand cross-links (ICLs); studies in C.elegans indicate that dog-1, the C. elegans functional orthlog of FANCJ, functions to maintain G-rich DNA and reduce ICL-induced damage, together with other FA pathway components.
Sequence connection from [Cheung I, Schertzer M, Rose A, Lansdorp RM], [020809 krb]
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.