WormBase Tree Display for Gene: WBGene00001130
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| WBGene00001130 | SMap | S_parent | Sequence | C02C6 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | dyn-1 | Person_evidence | WBPerson42 | |||||
| Sequence_name | C02C6.1 | ||||||||
| Molecular_name | C02C6.1a | ||||||||
| C02C6.1a.1 | |||||||||
| CE07833 | |||||||||
| C02C6.1b | |||||||||
| CE07832 | |||||||||
| C02C6.1b.1 | |||||||||
| Other_name | dyn1 | Accession_evidence | EMBL | L29031 | |||||
| CELE_C02C6.1 | Accession_evidence | NDB | BX284606 | ||||||
| Public_name | dyn-1 | ||||||||
| DB_info | Database (13) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:23 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | dyn | ||||||||
| Allele (91) | |||||||||
| Legacy_information | [Clark SG] ky51 is P70S change in dyn-1 GTPase domain, exhibits a ts Unc phenotype: mutants are apparently WT at 15C, but become Unc less than one minute after shift to 25C (sluggish, kinked, especially as larvae, Egl, Mel, not reversible by shift to 15C). Two alternatively spliced transcripts, encoding 838aa (DYN-1A) or 830aa (DYN-1B)proteins, 61% identical to human dynamin-I. dyn-1::lacZ expressed in motor neurons, intestine, pharyngeal muscle. Predicted gene C02C6.1a,b | ||||||||
| Complementation_data | [Clark SG] ky51 complements let-15(mn127), let-18(mn122), let-38(mn141), let-40(mn150) | ||||||||
| Strain | WBStrain00005363 | ||||||||
| WBStrain00002541 | |||||||||
| WBStrain00002824 | |||||||||
| WBStrain00005217 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (55) | |||||||||
| Ortholog (48) | |||||||||
| Paralog | WBGene00001093 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| WBGene00001134 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | dyn-1 encodes the C. elegans ortholog of the dynamin GTPase; dyn-1 activity is required for endocytosis, synaptic vesicle recycling, cytokinesis, and the CED-1 pathway that regulates engulfment and degradation of apoptotic cells; mutations in dyn-1 affect locomotion, egg-laying, defecation, and embryonic development, indicating that dyn-1's endocytic function is required for a number of diverse processes; dyn-1 reporter fusion constructs are expressed in motor neurons, intestinal cells, and pharyngeal muscle. | Paper_evidence | WBPaper00002892 | |||||
| WBPaper00003831 | |||||||||
| WBPaper00004812 | |||||||||
| WBPaper00005664 | |||||||||
| WBPaper00027659 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 02 Nov 2007 00:00:00 | ||||||||
| Automated_description | Enables GTPase activity. Involved in several processes, including embryo development; endocytosis; and necroptotic process. Located in several cellular components, including plasma membrane; plasma membrane bounded cell projection; and spindle microtubule. Expressed in several structures, including neurons; non-striated muscle; pharyngeal-intestinal valve; rectal valve cell; and somatic nervous system. Used to study early infantile epileptic encephalopathy. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; Charcot-Marie-Tooth disease dominant intermediate B; centronuclear myopathy 1; and developmental and epileptic encephalopathy (multiple). Is an ortholog of human DNM1 (dynamin 1); DNM2 (dynamin 2); and DNM3 (dynamin 3). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:0050709 | Homo sapiens | Paper_evidence | WBPaper00060104 | ||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 24 Aug 2020 00:00:00 | ||||||||
| Potential_model | DOID:0080437 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2972) | |||||
| DOID:10652 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2972) | ||||||
| DOID:0060558 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2974) | ||||||
| DOID:0110197 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2974) | ||||||
| DOID:0070376 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2972) | ||||||
| DOID:0111223 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2974) | ||||||
| Models_disease_asserted | WBDOannot00000798 | ||||||||
| Molecular_info | Corresponding_CDS | C02C6.1a | |||||||
| C02C6.1b | |||||||||
| Corresponding_transcript | C02C6.1a.1 | ||||||||
| C02C6.1b.1 | |||||||||
| Other_sequence (61) | |||||||||
| Associated_feature (11) | |||||||||
| Experimental_info | RNAi_result (52) | ||||||||
| Expr_pattern (16) | |||||||||
| Drives_construct (15) | |||||||||
| Construct_product (16) | |||||||||
| Antibody | WBAntibody00000197 | ||||||||
| WBAntibody00001270 | |||||||||
| WBAntibody00002116 | |||||||||
| WBAntibody00002189 | |||||||||
| Microarray_results (20) | |||||||||
| Expression_cluster (148) | |||||||||
| Interaction (173) | |||||||||
| Anatomy_function | WBbtf0490 | ||||||||
| WBProcess | WBbiopr:00000015 | ||||||||
| Map_info | Map | X | Position | 22.8512 | Error | 0.008189 | |||
| Well_ordered | |||||||||
| Positive | Inside_rearr | mnDf1 | |||||||
| mnDf4 | |||||||||
| mnDf8 | |||||||||
| Positive_clone | C02C6 | Inferred_automatically | From sequence, transcript, pseudogene data | ||||||
| Y53G9 | |||||||||
| Y69B5 | |||||||||
| Negative | Outside_rearr | mnDf43 | |||||||
| Mapping_data | Multi_point | 4273 | |||||||
| Pos_neg_data | 9355 | ||||||||
| 9356 | |||||||||
| 9357 | |||||||||
| 9358 | |||||||||
| Reference (119) | |||||||||
| Remark | Data extracted from Clark et al. (1997) | ||||||||
| Method | Gene |
