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WormBase Tree Display for Gene: WBGene00001165

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Name Class

WBGene00001165SMapS_parentSequenceF56A11
IdentityVersion1
NameCGC_nameefn-4Person_evidenceWBPerson893
Sequence_nameF56A11.3
Molecular_nameF56A11.3
F56A11.3.1
CE29503
Other_namemab-26
CELE_F56A11.3Accession_evidenceNDBBX284604
Public_nameefn-4
DB_infoDatabase (11)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:23WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classefn
Allele (170)
Legacy_information[C.elegansII] bx80sd : fusions among all rays; also head, body and (especially) tail deformities; bx80/+ impenetrant R4 to R3 transformation. [Chow and Emmons 1994; EM]
StrainWBStrain00005372
WBStrain00007176
WBStrain00049265
WBStrain00049276
RNASeq_FPKM (74)
GO_annotation (33)
Ortholog (50)
ParalogWBGene00001163Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00001164Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00006869Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
Structured_descriptionConcise_descriptionefn-4 encodes a divergent member of the ephrin family of ligands; efn-4 is required for neuroblast migrations during closure of the ventral gastrulation cleft and subsequent epidermal morphogenesis, possibly functioning independently of EFN-1, EFN-2, EFN-3, and the VAB-1 receptor during morphogenesis; EFN-4 can interact weakly with VAB-1 in vitro; EFN-4 is expressed in neural and epidermal precursors at the 100-cell stage, in head neurons, pharyngeal cells, lateral and tail neurons, and in the ectoderm during epidermal enclosure.Paper_evidenceWBPaper00003865
WBPaper00005631
Curator_confirmedWBPerson48
WBPerson1843
Date_last_updated23 Jul 2008 00:00:00
Automated_descriptionPredicted to enable ephrin receptor binding activity. Involved in several processes, including embryonic morphogenesis; nematode male tail tip morphogenesis; and regulation of axon guidance. Located in axon and neuronal cell body. Expressed in several structures, including CAN; epithelial cell; ganglia; intestinal cell; and somatic nervous system. Human ortholog(s) of this gene implicated in craniofrontonasal syndrome; dysostosis; and stomach cancer. Is an ortholog of human EFNB1 (ephrin B1).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_modelDOID:1934Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:3226)
DOID:10534Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:3226)
DOID:14737Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:3226)
Molecular_infoCorresponding_CDSF56A11.3
Corresponding_transcriptF56A11.3.1
Other_sequenceCR11929
TS00903
TSC03402_1
CRC05251_1
CBC06448_1
CR02130
Associated_feature (22)
Experimental_infoRNAi_resultWBRNAi00111800Inferred_automaticallyRNAi_primary
WBRNAi00067312Inferred_automaticallyRNAi_primary
WBRNAi00086136Inferred_automaticallyRNAi_primary
WBRNAi00067361Inferred_automaticallyRNAi_primary
WBRNAi00064650Inferred_automaticallyRNAi_primary
WBRNAi00048574Inferred_automaticallyRNAi_primary
WBRNAi00015760Inferred_automaticallyRNAi_primary
Expr_pattern (11)
Drives_constructWBCnstr00000722
WBCnstr00000723
WBCnstr00006419
WBCnstr00011024
WBCnstr00037053
WBCnstr00042431
WBCnstr00042437
Construct_productWBCnstr00006419
WBCnstr00021468
WBCnstr00021469
WBCnstr00021470
WBCnstr00021472
WBCnstr00021473
WBCnstr00021477
WBCnstr00022268
WBCnstr00037053
AntibodyWBAntibody00000596
Microarray_results (21)
Expression_cluster (158)
InteractionWBInteraction000000251
WBInteraction000002082
WBInteraction000002815
WBInteraction000002816
WBInteraction000002817
WBInteraction000002819
WBInteraction000004052
WBInteraction000004053
WBInteraction000004054
WBInteraction000004055
WBInteraction000004843
WBInteraction000004844
WBInteraction000005103
WBInteraction000005440
WBInteraction000005461
WBInteraction000005464
WBInteraction000006177
WBInteraction000006766
WBInteraction000006815
WBInteraction000008780
WBInteraction000008781
WBInteraction000008782
WBInteraction000008784
WBInteraction000028617
WBInteraction000029331
WBInteraction000029695
WBInteraction000029696
WBInteraction000029748
WBInteraction000030421
WBInteraction000030422
WBInteraction000030423
WBInteraction000126392
WBInteraction000136827
WBInteraction000140842
WBInteraction000140843
WBInteraction000140844
WBInteraction000140891
WBInteraction000153201
WBInteraction000165709
WBInteraction000165721
WBInteraction000166032
WBInteraction000166248
WBInteraction000166451
WBInteraction000268413
WBInteraction000322441
WBInteraction000356890
WBInteraction000366574
WBInteraction000367858
WBInteraction000369120
WBInteraction000371302
WBInteraction000392352
WBInteraction000392531
WBInteraction000417475
WBInteraction000442425
WBInteraction000446247
WBInteraction000459007
WBInteraction000541296
WBInteraction000553813
WBInteraction000556399
WBInteraction000560778
WBInteraction000560779
WBInteraction000560780
WBInteraction000560781
WBProcessWBbiopr:00000025
Map_infoMapIVPosition-25.7615Error0.138637
PositivePositive_cloneF56A11Inferred_automaticallyFrom CDS info
From sequence, transcript, pseudogene data
Mapping_dataMulti_point3132
4992
5641
Reference (44)
MethodGene