WormBase Tree Display for Gene: WBGene00001165

WBGene00001165 SMap: S_parent: Sequence: F56A11
  Identity: Version: 1
    Name: CGC_name: efn-4 Person_evidence: WBPerson893
      Sequence_name: F56A11.3
      Molecular_name: F56A11.3
        F56A11.3.1
        CE29503
      Other_name: mab-26
        CELE_F56A11.3 Accession_evidence: NDB BX284604
      Public_name: efn-4
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:23 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: efn
    Allele (170)
    Legacy_information: [C.elegansII] bx80sd : fusions among all rays; also head, body and (especially) tail deformities; bx80/+ impenetrant R4 to R3 transformation. [Chow and Emmons 1994; EM]
    Strain: WBStrain00005372
      WBStrain00007176
      WBStrain00049265
      WBStrain00049276
    RNASeq_FPKM (74)
    GO_annotation (33)
    Ortholog: WBGene00059483 Caenorhabditis remanei From_analysis: OMA
            Inparanoid_8
            WormBase-Compara
      WBGene00024824 Caenorhabditis briggsae From_analysis: Hillier-set
            OrthoMCL
            OMA
            Inparanoid_8
            WormBase-Compara
      WBGene00146874 Caenorhabditis brenneri From_analysis: OMA
            Inparanoid_8
            WormBase-Compara
      WBGene00146524 Caenorhabditis brenneri From_analysis: OMA
            Inparanoid_8
            WormBase-Compara
      WBGene00133236 Caenorhabditis japonica From_analysis: Inparanoid_8
            WormBase-Compara
      CBOVI.g11318 Caenorhabditis bovis From_analysis: WormBase-Compara
      CSP21.g3468 Caenorhabditis parvicauda From_analysis: WormBase-Compara
      CSP26.g18952 Caenorhabditis zanzibari From_analysis: WormBase-Compara
      CSP28.g7028 Caenorhabditis panamensis From_analysis: WormBase-Compara
      CSP29.g7151 Caenorhabditis becei From_analysis: WormBase-Compara
      CSP31.g12733 Caenorhabditis uteleia From_analysis: WormBase-Compara
      CSP32.g12841 Caenorhabditis sulstoni From_analysis: WormBase-Compara
      CSP38.g2348 Caenorhabditis quiockensis From_analysis: WormBase-Compara
      CSP39.g9366 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      CSP40.g12954 Caenorhabditis tribulationis From_analysis: WormBase-Compara
      Cni-efn-4 Caenorhabditis nigoni From_analysis: WormBase-Compara
      Csp11.Scaffold629.g7566 Caenorhabditis tropicalis From_analysis: WormBase-Compara
      Csp5_scaffold_01155.g18832 Caenorhabditis sinica From_analysis: WormBase-Compara
      FL83_16352 Caenorhabditis latens From_analysis: WormBase-Compara
      GCK72_014693 Caenorhabditis remanei From_analysis: WormBase-Compara
      OTIPU.nOt.2.0.1.g02766 Oscheius tipulae From_analysis: WormBase-Compara
      Sp34_40114300 Caenorhabditis inopinata From_analysis: WormBase-Compara
      chrIV_pilon.g9524 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00286612 Trichuris muris From_analysis: WormBase-Compara
      ZFIN:ZDB-GENE-990415-66 Danio rerio From_analysis: EnsEMBL-Compara
            Panther
            SonicParanoid
      ZFIN:ZDB-GENE-980526-186 Danio rerio From_analysis: EnsEMBL-Compara
            Panther
            SonicParanoid
      ZFIN:ZDB-GENE-001128-1 Danio rerio From_analysis: EnsEMBL-Compara
            Panther
            SonicParanoid
      ZFIN:ZDB-GENE-010618-2 Danio rerio From_analysis: EnsEMBL-Compara
            Inparanoid
            OrthoFinder
            Panther
            PhylomeDB
      ZFIN:ZDB-GENE-011108-1 Danio rerio From_analysis: EnsEMBL-Compara
            Panther
            SonicParanoid
      ZFIN:ZDB-GENE-040426-1135 Danio rerio From_analysis: EnsEMBL-Compara
            Panther
            SonicParanoid
      ZFIN:ZDB-GENE-041007-5 Danio rerio From_analysis: EnsEMBL-Compara
            Panther
            SonicParanoid
      ZFIN:ZDB-GENE-100922-64 Danio rerio From_analysis: EnsEMBL-Compara
            Panther
            SonicParanoid
      ZFIN:ZDB-GENE-060503-186 Danio rerio From_analysis: EnsEMBL-Compara
            Panther
            SonicParanoid
      HGNC:3221 Homo sapiens From_analysis: EnsEMBL-Compara
            Panther
            SonicParanoid
      HGNC:3222 Homo sapiens From_analysis: EnsEMBL-Compara
            Panther
            SonicParanoid
      HGNC:3223 Homo sapiens From_analysis: EnsEMBL-Compara
            Panther
            SonicParanoid
      HGNC:3224 Homo sapiens From_analysis: EnsEMBL-Compara
            Panther
            SonicParanoid
      HGNC:3225 Homo sapiens From_analysis: EnsEMBL-Compara
            Panther
            SonicParanoid
      HGNC:3226 Homo sapiens From_analysis: EnsEMBL-Compara
            OrthoFinder
            Panther
            PhylomeDB
      MGI:103236 Mus musculus From_analysis: EnsEMBL-Compara
            Inparanoid
            OrthoInspector
            Panther
            SonicParanoid
      MGI:102707 Mus musculus From_analysis: EnsEMBL-Compara
            Inparanoid
            Panther
            SonicParanoid
      MGI:106644 Mus musculus From_analysis: EnsEMBL-Compara
            Inparanoid
            Panther
            SonicParanoid
      MGI:106643 Mus musculus From_analysis: EnsEMBL-Compara
            Inparanoid
            Panther
            SonicParanoid
      MGI:107444 Mus musculus From_analysis: EnsEMBL-Compara
            Inparanoid
            Panther
            SonicParanoid
      RGD:620389 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Inparanoid
            Panther
            SonicParanoid
      RGD:620388 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Inparanoid
            Panther
            SonicParanoid
      RGD:620391 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Inparanoid
            Panther
            SonicParanoid
      RGD:620390 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Inparanoid
            Panther
            SonicParanoid
      RGD:1309497 Rattus norvegicus From_analysis: EnsEMBL-Compara
            OrthoFinder
            Panther
            PhylomeDB
      RGD:1307808 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Inparanoid
            Panther
            SonicParanoid
    Paralog: WBGene00001163 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00001164 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00006869 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
    Structured_description: Concise_description: efn-4 encodes a divergent member of the ephrin family of ligands; efn-4 is required for neuroblast migrations during closure of the ventral gastrulation cleft and subsequent epidermal morphogenesis, possibly functioning independently of EFN-1, EFN-2, EFN-3, and the VAB-1 receptor during morphogenesis; EFN-4 can interact weakly with VAB-1 in vitro; EFN-4 is expressed in neural and epidermal precursors at the 100-cell stage, in head neurons, pharyngeal cells, lateral and tail neurons, and in the ectoderm during epidermal enclosure. Paper_evidence: WBPaper00003865
            WBPaper00005631
          Curator_confirmed: WBPerson48
            WBPerson1843
          Date_last_updated: 23 Jul 2008 00:00:00
      Automated_description: Predicted to enable ephrin receptor binding activity. Involved in several processes, including embryonic morphogenesis; nematode male tail tip morphogenesis; and regulation of axon guidance. Located in axon and neuronal cell body. Expressed in several structures, including CAN; epithelial cell; ganglia; intestinal cell; and somatic nervous system. Human ortholog(s) of this gene implicated in craniofrontonasal syndrome; dysostosis; and stomach cancer. Is an ortholog of human EFNB1 (ephrin B1). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:1934 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:3226)
      DOID:10534 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:3226)
      DOID:14737 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:3226)
  Molecular_info: Corresponding_CDS: F56A11.3
    Corresponding_transcript: F56A11.3.1
    Other_sequence: CR11929
      TS00903
      TSC03402_1
      CRC05251_1
      CBC06448_1
      CR02130
    Associated_feature (22)
  Experimental_info: RNAi_result: WBRNAi00111800 Inferred_automatically: RNAi_primary
      WBRNAi00067312 Inferred_automatically: RNAi_primary
      WBRNAi00086136 Inferred_automatically: RNAi_primary
      WBRNAi00067361 Inferred_automatically: RNAi_primary
      WBRNAi00064650 Inferred_automatically: RNAi_primary
      WBRNAi00048574 Inferred_automatically: RNAi_primary
      WBRNAi00015760 Inferred_automatically: RNAi_primary
    Expr_pattern (11)
    Drives_construct: WBCnstr00000722
      WBCnstr00000723
      WBCnstr00006419
      WBCnstr00011024
      WBCnstr00037053
      WBCnstr00042431
      WBCnstr00042437
    Construct_product: WBCnstr00006419
      WBCnstr00021468
      WBCnstr00021469
      WBCnstr00021470
      WBCnstr00021472
      WBCnstr00021473
      WBCnstr00021477
      WBCnstr00022268
      WBCnstr00037053
    Antibody: WBAntibody00000596
    Microarray_results (21)
    Expression_cluster (158)
    Interaction (63)
    WBProcess: WBbiopr:00000025
  Map_info: Map: IV Position: -25.7615 Error: 0.138637
    Positive: Positive_clone: F56A11 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 3132
        4992
        5641
  Reference (44)
  Method: Gene