WormBase Tree Display for Gene: WBGene00001234
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| WBGene00001234 | Evidence | Author_evidence | Slack FJ | ||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | C47B2 | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | eif-6 | |||||||
| Sequence_name | C47B2.5 | ||||||||
| Molecular_name | C47B2.5 | ||||||||
| C47B2.5.1 | |||||||||
| CE17565 | |||||||||
| Other_name | CELE_C47B2.5 | Accession_evidence | NDB | BX284601 | |||||
| Public_name | eif-6 | ||||||||
| DB_info | Database | AceView | gene | 1N561 | |||||
| WormQTL | gene | WBGene00001234 | |||||||
| WormFlux | gene | WBGene00001234 | |||||||
| NDB | locus_tag | CELE_C47B2.5 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00001234|UniProtKB=O62106 | |||||||
| family | PTHR10784 | ||||||||
| NCBI | gene | 173169 | |||||||
| RefSeq | protein | NM_060871.8 | |||||||
| SwissProt | UniProtAcc | O62106 | |||||||
| TREEFAM | TREEFAM_ID | TF105396 | |||||||
| UniProt_GCRP | UniProtAcc | O62106 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:23 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | eif | ||||||||
| Allele (23) | |||||||||
| Strain | WBStrain00001619 | ||||||||
| WBStrain00047687 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (26) | |||||||||
| Contained_in_operon | CEOP1988 | ||||||||
| Ortholog (37) | |||||||||
| Structured_description | Concise_description | eif-6 encodes the C. elegans ortholog of vertebrate anti-association factor eIF6 and Saccharomyces cerevisiae Tif6p; EIF-6 is required for lin-4 miRNA-mediated repression of lin-14 and lin-28 mRNA and protein levels and in addition, is required for normal rates of growth and control of cell division in the germ line; eif-6 is expressed ubiquitously (or nearly so) in somatic larval and adult tissues; by orthology to eIF6 and Tif6p, EIF-6 is predicted to be recycled by K10C3.5 and W06E11.4 during maturation of 60S ribosomal subunits, suggesting a link between ribosome assembly and several processes, including miRNA-mediated gene silencing, germline proliferation, and regulation of growth rates; EIF-6 may suppress tumorous growth in the germ line by ensuring robust larval germline proliferation. | Paper_evidence | WBPaper00006525 | |||||
| WBPaper00028280 | |||||||||
| WBPaper00028930 | |||||||||
| WBPaper00028931 | |||||||||
| WBPaper00028932 | |||||||||
| WBPaper00029397 | |||||||||
| WBPaper00031006 | |||||||||
| WBPaper00032020 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 24 Jul 2008 00:00:00 | ||||||||
| Automated_description | Predicted to enable ribosomal large subunit binding activity. Involved in miRNA-mediated post-transcriptional gene silencing. Predicted to be located in cytosol and nucleolus. Predicted to be part of preribosome, large subunit precursor. Used to study obesity. Is an ortholog of human EIF6 (eukaryotic translation initiation factor 6). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:9970 | Homo sapiens | Paper_evidence | WBPaper00061889 | ||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 28 Jun 2022 00:00:00 | ||||||||
| Models_disease_in_annotation | WBDOannot00001258 | ||||||||
| Molecular_info | Corresponding_CDS | C47B2.5 | |||||||
| Corresponding_transcript | C47B2.5.1 | ||||||||
| Other_sequence (76) | |||||||||
| Associated_feature | WBsf654836 | ||||||||
| WBsf985741 | |||||||||
| WBsf218663 | |||||||||
| WBsf218664 | |||||||||
| Experimental_info | RNAi_result (17) | ||||||||
| Expr_pattern | Chronogram1152 | ||||||||
| Chronogram1473 | |||||||||
| Chronogram1775 | |||||||||
| Expr5524 | |||||||||
| Expr1026159 | |||||||||
| Expr1030782 | |||||||||
| Expr1146640 | |||||||||
| Expr2011263 | |||||||||
| Expr2029499 | |||||||||
| Drives_construct | WBCnstr00002458 | ||||||||
| WBCnstr00004347 | |||||||||
| Microarray_results (23) | |||||||||
| Expression_cluster (139) | |||||||||
| Interaction (166) | |||||||||
| Map_info | Map | I | Position | 16.7968 | Error | 0.002957 | |||
| Positive | Positive_clone | C47B2 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 94 | |||||||
| Pseudo_map_position | |||||||||
| Reference | WBPaper00028280 | ||||||||
| WBPaper00029397 | |||||||||
| WBPaper00038491 | |||||||||
| WBPaper00049828 | |||||||||
| WBPaper00055090 | |||||||||
| WBPaper00061889 | |||||||||
| WBPaper00064339 | |||||||||
| WBPaper00065861 | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
