| WBGene00001400 | SMap | S_parent | Sequence | F56E3 |
|---|
| Identity | Version | 1 |
| | Name | CGC_name | fax-1 | Person_evidence | WBPerson691 |
| | | Sequence_name | F56E3.4 |
| | | Molecular_name | F56E3.4a |
| | | | F56E3.4a.1 |
| | | | CE28464 |
| | | | F56E3.4b |
| | | | CE04670 |
| | | | F56E3.4b.1 |
| | | Other_name | nhr-29 |
| | | | CELE_F56E3.4 | Accession_evidence | NDB | BX284606 |
| | | Public_name | fax-1 |
| | DB_info | Database | AceView | gene | XD816 |
| | | | WormQTL | gene | WBGene00001400 |
| | | | WormFlux | gene | WBGene00001400 |
| | | | NDB | locus_tag | CELE_F56E3.4 |
| | | | Panther | gene | CAEEL|WormBase=WBGene00001400|UniProtKB=G5EDJ0 |
| | | | | family | PTHR24083 |
| | | | NCBI | gene | 180609 |
| | | | RefSeq | protein | NM_001277024.2 |
| | | | | | NM_076146.4 |
| | | | SwissProt | UniProtAcc | G5EDJ0 |
| | | | UniProt_GCRP | UniProtAcc | G5EDJ0 |
| | | | OMIM | gene | 604485 |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:24 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | fax |
| | Allele (57) |
| | Legacy_information | [Wightman B] Mutations cause a weak kinker phenotype and defects in axon guidance of HSNL, AVKR, PVQL axons. |
| | | [Wightman B] encoded by F56E3.4 nuclear hormone receptor, mutants are Unc, egg-laying constitutive, and have defects in axon pathfinding in the ventral nerve cord. |
| | Strain | WBStrain00027632 |
| | | WBStrain00001394 |
| | | WBStrain00027630 |
| | | WBStrain00028736 |
| | | WBStrain00028744 |
| | | WBStrain00031525 |
| | RNASeq_FPKM (74) |
| | GO_annotation (33) |
| | Ortholog (34) |
| | Paralog (43) |
| | Structured_description | Concise_description | fax-1 encodes a conserved nuclear receptor that contains two C4-type zinc fingers and is orthologous to the vertebrate photoreceptor-specific nuclear receptor PNR (OMIM:604485, mutated in enhanced S-cone syndrome and retinitis pigmentosa); fax-1 is required for normal locomotion and neuron fate specification, including specification of the AVA, AVE, and AVK interneurons and proper axon pathfinding of the AVK, HSNL, and PVQL axons; expression of reporter gene fusions in fax-1 mutants suggests that fax-1 functions by regulating expression of a number of downstream targets, including nmr-1 and nmr-2, opt-3, flp-1, and ncs-1; in some neurons, fax-1 regulates expression combinatorially with unc-42, which encodes a paired-like homeodomain protein that additionally, regulates fax-1 expression in AVK neurons; FAX-1 exhibits sequence-specific DNA binding in vitro and the FAX-1 DNA binding domain, when fused to the GAL4 transcriptional activator, can positively regulate transcription in yeast one-hybrid assays; FAX-1 is expressed in the nuclei of 18 neurons, including the AVK, AVA, AVB, and AVE interneurons, beginning at mid-embryogenesis and continuing through larval and adult stages; FAX-1 is also seen in two non-neuronal cell types: the distal tip cells (DTCs), from L2 to L4 larval stages, and two pairs of vulval cells in L4 animals. | Paper_evidence | WBPaper00003941 |
| | | | | | WBPaper00026828 |
| | | | | | WBPaper00031380 |
| | | | | Curator_confirmed | WBPerson1843 |
| | | | | | WBPerson1823 |
| | | | | | WBPerson567 |
| | | | | Date_last_updated | 09 Oct 2008 00:00:00 |
| | | Automated_description | Enables DNA-binding transcription factor activity, RNA polymerase II-specific and sequence-specific DNA binding activity. Involved in several processes, including neuron differentiation; positive regulation of transcription by RNA polymerase II; and regulation of locomotion. Located in nucleus. Expressed in several structures, including CEP; hermaphrodite distal tip cell; interneuron; pharyngeal motor neurons; and rect_D. Human ortholog(s) of this gene implicated in enhanced S-cone syndrome and retinitis pigmentosa 37. Is an ortholog of human NR2E3 (nuclear receptor subfamily 2 group E member 3). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Disease_info | Potential_model | DOID:0090059 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:7974) |
| | | DOID:0110399 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:7974) |
| Molecular_info | Corresponding_CDS | F56E3.4a |
| | | F56E3.4b |
| | Corresponding_transcript | F56E3.4a.1 |
| | | F56E3.4b.1 |
| | Other_sequence | SRC02099_1 |
| | | Acan_isotig10071 |
| | | EY464040.1 |
| | | SR01788 |
| | | FC815338.1 |
| | | JI475021.1 |
| | | CRC12381_1 |
| | | JI170219.1 |
| | Associated_feature (11) |
| | Transcription_factor | WBTranscriptionFactor000521 |
| Experimental_info | RNAi_result | WBRNAi00027911 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00048731 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00115862 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00015835 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00048732 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00015837 | Inferred_automatically | RNAi_primary |
| | Expr_pattern (12) |
| | Drives_construct | WBCnstr00002284 |
| | | WBCnstr00004291 |
| | | WBCnstr00012731 |
| | | WBCnstr00013827 |
| | | WBCnstr00036970 |
| | Construct_product | WBCnstr00013827 |
| | | WBCnstr00021906 |
| | | WBCnstr00036970 |
| | Antibody | WBAntibody00000945 |
| | | WBAntibody00002352 |
| | Microarray_results (22) |
| | Expression_cluster | WBPaper00033065:cyc-1(RNAi)_downregulated |
| | | WBPaper00037950:A-class-motor-neurons_L1-larva_expressed |
| | | WBPaper00037950:all-neurons_L1-larva_expressed |
| | | WBPaper00037950:all-neurons_larva_enriched |
| | | WBPaper00037950:all-neurons_larva_SelectivelyEnriched |
| | | WBPaper00037950:AVA-neuron_embryo_enriched |
| | | WBPaper00037950:AVA-neuron_embryo_SelectivelyEnriched |
| | | WBPaper00037950:AVA-neuron_L1-larva_expressed |
| | | WBPaper00037950:AVE-neuron_embryo_enriched |
| | | WBPaper00037950:AVE-neuron_embryo_SelectivelyEnriched |
| | | WBPaper00037950:coelomocytes_L1-larva_expressed |
| | | WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed |
| | | WBPaper00037950:glr-1(+)-neurons_larva_enriched |
| | | WBPaper00037950:glr-1(+)-neurons_larva_SelectivelyEnriched |
| | | WBPaper00037950:hypodermis_L1-larva_expressed |
| | | WBPaper00038438:D.coniospora_12hr_downregulated_RNAseq |
| | | WBPaper00038438:E.faecalis_24hr_upregulated_TilingArray |
| | | WBPaper00045316:prg-1_upregulated_L2 |
| | | WBPaper00045390:ubc-9(RNAi)_downregulated |
| | | WBPaper00048690:gonad-hermaphrodite-biased |
| | | WBPaper00048690:hermaphrodite-Z1-Z4-daughter_enriched |
| | | WBPaper00048988:neuron_enriched |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049545:cco-1(RNAi)_upregulated |
| | | WBPaper00050496:RID_enriched |
| | | WBPaper00050496:unc-39(hp701)_regulated |
| | | WBPaper00050726:OsmoticStress_regulated_Food |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00053302:stavudine_24h_regulated |
| | | WBPaper00053302:zidovudine_72h_regulated |
| | | WBPaper00053771:up_at_dpy-7(e88) |
| | | WBPaper00054758:alg-1(gk204)_upregulated |
| | | WBPaper00055103:thoc-5(wy822)_upregulated |
| | | WBPaper00055354:eat-2(ad1116)_upregulated |
| | | WBPaper00055354:Psora-Allantoin_upregulated |
| | | WBPaper00055354:Rapamycin-Metformin_upregulated |
| | | WBPaper00055354:Rapamycin_downregulated |
| | | WBPaper00055354:Rifampicin_upregulated |
| | | WBPaper00055565:AVK_enriched |
| | | WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047) |
| | | WBPaper00056090:E.faecalis_upregulated_N2 |
| | | WBPaper00056167:Cry5B_upregulated |
| | | WBPaper00056169:rrf-3(pk1426)_upregulated_embryo |
| | | WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated |
| | | WBPaper00057041:unc-70(cas983)_downregulated |
| | | WBPaper00057068:ints-4(RNAi)_upregulated |
| | | WBPaper00057068:ints-4(RNAi)_upregulated_Cadmium |
| | | WBPaper00058598:mex-1(or286)_upregulated |
| | | WBPaper00058598:mex-3(eu149)_upregulated |
| | | WBPaper00058598:sin-3(tm1276)_downregulated |
| | | WBPaper00058598:spn-4(tm291)_upregulated |
| | | WBPaper00058691:set-2(bn129)_upregulated |
| | | WBPaper00058948:PA14_downregulated |
| | | WBPaper00059027:neuron-synapses_depleted |
| | | WBPaper00059421:daf-1(m40);daf-3(mgDf90)_downregulated |
| | | WBPaper00059421:daf-3(mgDf90)_downregulated |
| | | WBPaper00059537:ngn-1(ok2200)_downregulated |
| | | WBPaper00059763:neuron_acr-2(n2420gf)_regulated |
| | | WBPaper00060014:set-2(tm1630)_downregulated |
| | | WBPaper00060014:set-2(zr2012)_downregulated |
| | | WBPaper00060661:sensory-neuron_enriched |
| | | WBPaper00060811:L1_vs_adult_upregulated_neural |
| | | WBPaper00061203:sin-3(tm1276)_upregulated |
| | | WBPaper00061203:spr-1(ok2144)_upregulated |
| | | WBPaper00061340:AIY |
| | | WBPaper00061340:AVA |
| | | WBPaper00061340:AVB |
| | | WBPaper00061340:AVE |
| | | WBPaper00061340:AVK |
| | | WBPaper00061340:DVA |
| | | WBPaper00061340:Parent_of_PVP_and_rect_V |
| | | WBPaper00061340:RIC |
| | | WBPaper00061340:RIC_parent |
| | | WBPaper00061340:SIB |
| | | WBPaper00061439:unc-30(ok613)_upregulated_P.aeruginosa-infection |
| | | WBPaper00061479:hda-1(ne4752)_upregulated |
| | | WBPaper00061527:rab-28-jbts-14_9542 |
| | | WBPaper00061651:I3_enriched |
| | | WBPaper00061651:RIC_enriched |
| | | WBPaper00061995:mter-4(syb3662syb3403)_downregulated |
| | | WBPaper00062103:neuron_enriched |
| | | WBPaper00062159:hda-2(ok1479)_upregulated |
| | | WBPaper00062325:muscle_depleted_coding-RNA |
| | | WBPaper00062440:crh-1(n3315)_downregulated |
| | | WBPaper00062446:nhr-8(hd117)_upregulated |
| | | WBPaper00064306:Agaro-oligosaccharides_upregulated |
| | | WBPaper00064933:bcf-1(ylf1)_upregulated_transcript |
| | | WBPaper00065029:cadmium_upregulated |
| | | WBPaper00065096:25C_vs_20C_downregulated |
| | | WBPaper00065096:Day10_vs_Day1_downregulated |
| | | WBPaper00065258:anchor-cell_enriched |
| | | WBPaper00065560:E.coli-HB101_downregulated_F3 |
| | | WBPaper00065749:endu-2(tm4977)_upregulated |
| | | WBPaper00065749:Heat-Shock_downregulated_N2 |
| | | WBPaper00065841:22_0 |
| | | WBPaper00065841:31_0 |
| | | WBPaper00065841:48_0 |
| | | WBPaper00065841:58_1 |
| | | WBPaper00065841:71_0 |
| | | WBPaper00065841:74_0 |
| | | WBPaper00065841:98_0 |
| | | WBPaper00065993:glp-1(e2141)_downregulated |
| | | cgc4489_group_15 |
| | | cgc4489_group_18 |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00026929:sir-2.1_overexpression_regulated |
| | | WBPaper00030839:Larval_Pan_Neuronal |
| | | WBPaper00045960:L4-lethargus_downregulated |
| | Interaction (20) |
| Map_info | Map | X | Position | -10.7537 | Error | 0.119879 |
| | Well_ordered |
| | Positive | Inside_rearr | syDf1 |
| | | | yDp14 |
| | | Positive_clone | C02A6 | Author_evidence | Wightman BC |
| | | | C38F12 | Author_evidence | Wightman BC |
| | | | F56E3 | Author_evidence | Wightman BC |
| | | | | Inferred_automatically | From sequence, transcript, pseudogene data |
| | | | W05A4 | Author_evidence | Wightman BC |
| | Negative | Negative_clone | C15C7 | Author_evidence | Wightman BC |
| | | | F28B4 | Author_evidence | Wightman BC |
| | | | F40F4 | Author_evidence | Wightman BC |
| | Mapping_data | Multi_point | 3537 |
| | | | 3538 |
| | | | 3539 |
| | | | 3696 |
| | | | 5603 |
| | | Pos_neg_data | 9117 |
| | | | 9118 |
| Reference (56) |
| Method | Gene |
