WormBase Tree Display for Gene: WBGene00001400
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WBGene00001400 | SMap | S_parent | Sequence | F56E3 | |||
---|---|---|---|---|---|---|---|
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | fax | ||||||
Allele (57) | |||||||
Legacy_information | [Wightman B] Mutations cause a weak kinker phenotype and defects in axon guidance of HSNL, AVKR, PVQL axons. | ||||||
[Wightman B] encoded by F56E3.4 nuclear hormone receptor, mutants are Unc, egg-laying constitutive, and have defects in axon pathfinding in the ventral nerve cord. | |||||||
Strain | WBStrain00027632 | ||||||
WBStrain00001394 | |||||||
WBStrain00027630 | |||||||
WBStrain00028736 | |||||||
WBStrain00028744 | |||||||
WBStrain00031525 | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation | 00014093 | ||||||
00014094 | |||||||
00014095 | |||||||
00014096 | |||||||
00014097 | |||||||
00014098 | |||||||
00014099 | |||||||
00014100 | |||||||
00014101 | |||||||
00014102 | |||||||
00014103 | |||||||
00014104 | |||||||
00014105 | |||||||
00014106 | |||||||
00014107 | |||||||
00014108 | |||||||
00014109 | |||||||
00014110 | |||||||
00014111 | |||||||
00014112 | |||||||
00014113 | |||||||
00014114 | |||||||
00014115 | |||||||
00014116 | |||||||
00014117 | |||||||
00014118 | |||||||
00014119 | |||||||
00014120 | |||||||
00014121 | |||||||
00108663 | |||||||
00108664 | |||||||
00108665 | |||||||
00108666 | |||||||
Ortholog (34) | |||||||
Paralog (43) | |||||||
Structured_description | Concise_description | fax-1 encodes a conserved nuclear receptor that contains two C4-type zinc fingers and is orthologous to the vertebrate photoreceptor-specific nuclear receptor PNR (OMIM:604485, mutated in enhanced S-cone syndrome and retinitis pigmentosa); fax-1 is required for normal locomotion and neuron fate specification, including specification of the AVA, AVE, and AVK interneurons and proper axon pathfinding of the AVK, HSNL, and PVQL axons; expression of reporter gene fusions in fax-1 mutants suggests that fax-1 functions by regulating expression of a number of downstream targets, including nmr-1 and nmr-2, opt-3, flp-1, and ncs-1; in some neurons, fax-1 regulates expression combinatorially with unc-42, which encodes a paired-like homeodomain protein that additionally, regulates fax-1 expression in AVK neurons; FAX-1 exhibits sequence-specific DNA binding in vitro and the FAX-1 DNA binding domain, when fused to the GAL4 transcriptional activator, can positively regulate transcription in yeast one-hybrid assays; FAX-1 is expressed in the nuclei of 18 neurons, including the AVK, AVA, AVB, and AVE interneurons, beginning at mid-embryogenesis and continuing through larval and adult stages; FAX-1 is also seen in two non-neuronal cell types: the distal tip cells (DTCs), from L2 to L4 larval stages, and two pairs of vulval cells in L4 animals. | Paper_evidence | WBPaper00003941 | |||
WBPaper00026828 | |||||||
WBPaper00031380 | |||||||
Curator_confirmed | WBPerson1843 | ||||||
WBPerson1823 | |||||||
WBPerson567 | |||||||
Date_last_updated | 09 Oct 2008 00:00:00 | ||||||
Automated_description | Enables DNA-binding transcription factor activity, RNA polymerase II-specific and sequence-specific DNA binding activity. Involved in several processes, including neuron differentiation; positive regulation of transcription by RNA polymerase II; and regulation of locomotion. Located in nucleus. Expressed in several structures, including CEP; hermaphrodite distal tip cell; interneuron; pharyngeal motor neurons; and rect_D. Human ortholog(s) of this gene implicated in enhanced S-cone syndrome and retinitis pigmentosa 37. Is an ortholog of human NR2E3 (nuclear receptor subfamily 2 group E member 3). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info | Potential_model | DOID:0090059 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:7974) | ||
DOID:0110399 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:7974) | ||||
Molecular_info | Corresponding_CDS | F56E3.4a | |||||
F56E3.4b | |||||||
Corresponding_transcript | F56E3.4a.1 | ||||||
F56E3.4b.1 | |||||||
Other_sequence | SRC02099_1 | ||||||
Acan_isotig10071 | |||||||
EY464040.1 | |||||||
SR01788 | |||||||
FC815338.1 | |||||||
JI475021.1 | |||||||
CRC12381_1 | |||||||
JI170219.1 | |||||||
Associated_feature (11) | |||||||
Transcription_factor | WBTranscriptionFactor000521 | ||||||
Experimental_info | RNAi_result | WBRNAi00027911 | Inferred_automatically | RNAi_primary | |||
WBRNAi00048731 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00115862 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00015835 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00048732 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00015837 | Inferred_automatically | RNAi_primary | |||||
Expr_pattern (12) | |||||||
Drives_construct | WBCnstr00002284 | ||||||
WBCnstr00004291 | |||||||
WBCnstr00012731 | |||||||
WBCnstr00013827 | |||||||
WBCnstr00036970 | |||||||
Construct_product | WBCnstr00013827 | ||||||
WBCnstr00021906 | |||||||
WBCnstr00036970 | |||||||
Antibody | WBAntibody00000945 | ||||||
WBAntibody00002352 | |||||||
Microarray_results (22) | |||||||
Expression_cluster (108) | |||||||
Interaction (20) | |||||||
Map_info | Map | X | Position | -10.7537 | Error | 0.119879 | |
Well_ordered | |||||||
Positive | Inside_rearr | syDf1 | |||||
yDp14 | |||||||
Positive_clone | C02A6 | Author_evidence | Wightman BC | ||||
C38F12 | Author_evidence | Wightman BC | |||||
F56E3 | Author_evidence | Wightman BC | |||||
Inferred_automatically | From sequence, transcript, pseudogene data | ||||||
W05A4 | Author_evidence | Wightman BC | |||||
Negative | Negative_clone | C15C7 | Author_evidence | Wightman BC | |||
F28B4 | Author_evidence | Wightman BC | |||||
F40F4 | Author_evidence | Wightman BC | |||||
Mapping_data | Multi_point | 3537 | |||||
3538 | |||||||
3539 | |||||||
3696 | |||||||
5603 | |||||||
Pos_neg_data | 9117 | ||||||
9118 | |||||||
Reference (56) | |||||||
Method | Gene |