WormBase Tree Display for Gene: WBGene00001405
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| WBGene00001405 | Evidence | Paper_evidence | WBPaper00005794 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | C04F12 | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | fce-1 | |||||||
| Sequence_name | C04F12.10 | ||||||||
| Molecular_name | C04F12.10 | ||||||||
| C04F12.10.1 | |||||||||
| CE19683 | |||||||||
| Other_name | Ce-face-1 | ||||||||
| CELE_C04F12.10 | Accession_evidence | NDB | BX284601 | ||||||
| Public_name | fce-1 | ||||||||
| DB_info | Database (13) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:24 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | fce | ||||||||
| Allele (25) | |||||||||
| Strain | WBStrain00002799 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (18) | |||||||||
| Contained_in_operon | CEOP1560 | ||||||||
| Ortholog (40) | |||||||||
| Structured_description | Concise_description | fce-1 encodes an ortholog of 'farnesylated-proteins converting enzyme 1' (FACE-1), and thus probably enables post-translational processing of proteins (such as LET-60/RAS) carrying a C-terminal CaaX motif; FCE-1 protein probably accounts for the EDTA-sensitive, tosylphenylalanylchloromethane-insensitive component of CaaX-proteolytic activity in membrane extracts from C. elegans, and FCE-1 can cleave a farnesylated peptide in vitro; the S. cerevisiae homolog of FCE-1 (Ste24p) cleaves the precursor of yeast a-factor mating pheromone after its farnesylated cysteine residue, and transgenic FCE-1 rescues a mating defect of mutant yeast lacking both the Ste24p and the Rce1p CaaX-proteases. | Paper_evidence | WBPaper00003125 | |||||
| WBPaper00005794 | |||||||||
| Curator_confirmed | WBPerson567 | ||||||||
| Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
| Automated_description | Enables metalloendopeptidase activity. Involved in CAAX-box protein processing. Located in membrane. Expressed in head. Human ortholog(s) of this gene implicated in mandibuloacral dysplasia type B lipodystrophy and restrictive dermopathy 1. Is an ortholog of human ZMPSTE24 (zinc metallopeptidase STE24). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0081129 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12877) | ||||
| DOID:0060762 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12877) | ||||||
| DOID:0070369 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12877) | ||||||
| Molecular_info | Corresponding_CDS | C04F12.10 | |||||||
| Corresponding_transcript | C04F12.10.1 | ||||||||
| Other_sequence (69) | |||||||||
| Associated_feature | WBsf034262 | ||||||||
| WBsf984788 | |||||||||
| WBsf220134 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00088976 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00028438 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00002901 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00039624 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00061387 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00076076 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00116823 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Chronogram1634 | ||||||||
| Expr5144 | |||||||||
| Expr1017723 | |||||||||
| Expr1030842 | |||||||||
| Expr1143723 | |||||||||
| Expr2011742 | |||||||||
| Expr2029980 | |||||||||
| Drives_construct | WBCnstr00003326 | ||||||||
| Microarray_results (21) | |||||||||
| Expression_cluster (75) | |||||||||
| Interaction (66) | |||||||||
| Map_info | Map | I | Position | 3.86008 | Error | 0.001181 | |||
| Positive | Positive_clone | C04F12 | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Pseudo_map_position | |||||||||
| Reference | WBPaper00005794 | ||||||||
| WBPaper00038491 | |||||||||
| WBPaper00041771 | |||||||||
| WBPaper00055090 | |||||||||
| WBPaper00064339 | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
