WormBase Tree Display for Gene: WBGene00001411
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| WBGene00001411 | SMap | S_parent | Sequence | F35D6 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | fem-1 | Person_evidence | WBPerson261 | |||||
| Sequence_name | F35D6.1 | ||||||||
| Molecular_name | F35D6.1a | ||||||||
| F35D6.1a.1 | |||||||||
| CE07175 | |||||||||
| F35D6.1b | |||||||||
| CE28299 | |||||||||
| F35D6.1b.1 | |||||||||
| Other_name | isx-1 | ||||||||
| CELE_F35D6.1 | Accession_evidence | NDB | BX284604 | ||||||
| Public_name | fem-1 | ||||||||
| DB_info | Database | AceView | gene | 4G298 | |||||
| WormQTL | gene | WBGene00001411 | |||||||
| WormFlux | gene | WBGene00001411 | |||||||
| NDB | locus_tag | CELE_F35D6.1 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00001411|UniProtKB=P17221 | |||||||
| family | PTHR24173 | ||||||||
| NCBI | gene | 177335 | |||||||
| RefSeq | protein | NM_068423.7 | |||||||
| NM_001392312.1 | |||||||||
| SwissProt | UniProtAcc | P17221 | |||||||
| TREEFAM | TREEFAM_ID | TF351376 | |||||||
| UniProt_GCRP | UniProtAcc | P17221 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:24 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | fem | ||||||||
| Reference_allele | WBVar00144434 | ||||||||
| Allele (108) | |||||||||
| Possibly_affected_by | WBVar02158627 | ||||||||
| Legacy_information | e1965mat : XO animals transformed into fertile females if mother homozygous e1965 into intersexes if mother heterozygous e1965/+; XX animals fertile females if mother homozygous fertile females or hermaphrodites if mother heterozygous. ES3 (XO adult) ES2 (XX adult) ME0. NA > 20 (e1991amber (resembles e1965) etc); also many ts alleles eg hc17ts (pka isx-1 : causes only partial XO feminization at 25x XX self fertile at 20x). | ||||||||
| See also e1949, e1974, e1994, e2044, e2066, e2108, e2177, e2179, e2180, e2195, e2196, e2197, e2265, e2266, e2267, e2268, e2287, e2288, e2290, e2350, e2362, e2365, e2367, e2382, hc17 | |||||||||
| [C.elegansII] e1965mat : XO animals transformed into fertile females if mother homozygous, into intersexes if mother heterozygous. XX animals females if mother homozygous, femalesor hermaphrodites if mother heterozygous. Null allele. ES3 (XO adult) ES2 (XX adult) ME0. OA>20: e1991amb (resembles e1965), e1949, etc.; also many ts alleles, hc17ts (pka isx-1, causes only partial XO feminization at 25C, XX self fertile at 20C), e1918ts, e1988ts, e1973ts. Cloned : 2.4 kb transcript, encodes 656 aaprotein with 6 ANK repeats. Antibody staining indicates present in both sexes, both germline and soma. [Doniach and Hodgkin 1984; Spence et al. 1990; AS] | |||||||||
| Strain (16) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (26) | |||||||||
| Ortholog (46) | |||||||||
| Paralog | WBGene00014077 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WBGene00006490 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00016661 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| Structured_description | Concise_description | The fem-1 gene encodes an ankyrin repeat-containing protein orthologous to human FEM1A and is required for masculinization of germline and somatic tissues; FEM-1 is widely expressed and functions as a second messenger in the sex determination pathway, connecting the membrane protein TRA-2A to the transcription factor TRA-1A which it negatively regulates; FEM-1 may also play a role in apoptosis, as it is a substrate for the CED-3 protease and can induce apoptosis when overexpressed in mammalian cells. | Paper_evidence | WBPaper00000724 | |||||
| WBPaper00004180 | |||||||||
| WBPaper00004480 | |||||||||
| WBPaper00005549 | |||||||||
| WBPaper00005643 | |||||||||
| WBPaper00012929 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 16 Jan 2009 00:00:00 | ||||||||
| Automated_description | Enables protein phosphatase binding activity. Involved in several processes, including proteasome-mediated ubiquitin-dependent protein catabolic process; regulation of germ cell proliferation; and sex determination. Located in protein-containing complex. Part of Cul2-RING ubiquitin ligase complex. Expressed in several structures, including germ line. Is an ortholog of human FEM1A (fem-1 homolog A) and FEM1C (fem-1 homolog C). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | F35D6.1a | |||||||
| F35D6.1b | |||||||||
| Corresponding_transcript | F35D6.1a.1 | ||||||||
| F35D6.1b.1 | |||||||||
| Other_sequence | CBC04060_1 | ||||||||
| JI168154.1 | |||||||||
| CBC17707_1 | |||||||||
| Oden_contig21629 | |||||||||
| CR03385 | |||||||||
| CR03262 | |||||||||
| Dviv_isotig20887 | |||||||||
| CRC04185_1 | |||||||||
| Associated_feature (13) | |||||||||
| Experimental_info | RNAi_result (12) | ||||||||
| Expr_pattern | Expr674 | ||||||||
| Expr675 | |||||||||
| Expr676 | |||||||||
| Expr9652 | |||||||||
| Expr1019765 | |||||||||
| Expr1030845 | |||||||||
| Expr1150221 | |||||||||
| Expr2011749 | |||||||||
| Expr2029987 | |||||||||
| Drives_construct | WBCnstr00000635 | ||||||||
| WBCnstr00000636 | |||||||||
| WBCnstr00008964 | |||||||||
| WBCnstr00008968 | |||||||||
| WBCnstr00036965 | |||||||||
| Construct_product | WBCnstr00036965 | ||||||||
| Antibody | WBAntibody00000113 | ||||||||
| Microarray_results (32) | |||||||||
| Expression_cluster (84) | |||||||||
| Interaction (87) | |||||||||
| WBProcess | WBbiopr:00000001 | ||||||||
| WBbiopr:00000014 | |||||||||
| WBbiopr:00000110 | |||||||||
| Map_info | Map | IV | Position | 1.80774 | Error | 0.002897 | |||
| Well_ordered | |||||||||
| Positive | Inside_rearr | idDf3 | |||||||
| Positive_clone | C17E1 | ||||||||
| F35D6 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||||
| Mapping_data | 2_point | 106 | |||||||
| 3378 | |||||||||
| Multi_point | 114 | ||||||||
| 776 | |||||||||
| 777 | |||||||||
| 778 | |||||||||
| 1122 | |||||||||
| 1287 | |||||||||
| 1708 | |||||||||
| Pos_neg_data | 9032 | ||||||||
| 9037 | |||||||||
| 10893 | |||||||||
| Reference (298) | |||||||||
| Picture | WBPicture0000013095 | ||||||||
| Remark | yk13e8.3 removed from sequence list sdm 11/00 | ||||||||
| Method | Gene |
