WormBase Tree Display for Gene: WBGene00001431
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| WBGene00001431 | SMap | S_parent | Sequence | F31D4 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | fkb-6 | Person_evidence | WBPerson466 | |||||
| Sequence_name | F31D4.3 | ||||||||
| Molecular_name | F31D4.3 | ||||||||
| F31D4.3.1 | |||||||||
| CE15929 | |||||||||
| Other_name | CELE_F31D4.3 | Accession_evidence | NDB | BX284605 | |||||
| Public_name | fkb-6 | ||||||||
| DB_info | Database (12) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:24 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | fkb | ||||||||
| Allele (29) | |||||||||
| Legacy_information | [Page AP] F31D4.3. No mutants known. | ||||||||
| Strain | WBStrain00001608 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (11) | |||||||||
| Ortholog (41) | |||||||||
| Paralog | WBGene00001426 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| WBGene00001427 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00001433 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00001428 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00001429 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00001430 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00001432 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| Structured_description | Concise_description | fkb-6 encodes a peptidyl-prolyl cis-trans isomerase that is most closely related to mammalian FK506-binding protein 4; loss of fkb-6 activity via large-scale RNAi screens indicates that fkb-6 is required for embryonic and vulval development as well as wild type brood size; fkb-6 controls chromosome movement during meiotic prophase I, and thus pairing and synapsis; FKB-6 exhibits peptidyl-prolyl cis-trans isomerase activity in vitro, and physically interacts with the Hsp90 ortholog DAF-21; fkb-6 is expressed throughout the life cycle, but is seen predominantly in the adult dorsal, ventral nerve cords and germline with additional expression seen in the pharynx, hypodermis, body wall muscle cells and some somatic and gut cells. | Paper_evidence | WBPaper00005599 | |||||
| WBPaper00024497 | |||||||||
| WBPaper00030836 | |||||||||
| WBPaper00051337 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 12 Sep 2017 00:00:00 | ||||||||
| Automated_description | Enables Hsp90 protein binding activity and peptidyl-prolyl cis-trans isomerase activity. Predicted to be involved in chaperone-mediated protein folding. Predicted to be located in cytoplasm. Expressed in dorsal nerve cord; intestine; and ventral nerve cord. Human ortholog(s) of this gene implicated in major depressive disorder. Is an ortholog of human FKBP4 (FKBP prolyl isomerase 4) and FKBP5 (FKBP prolyl isomerase 5). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:1470 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3721) | ||||
| Molecular_info | Corresponding_CDS | F31D4.3 | |||||||
| Corresponding_transcript | F31D4.3.1 | ||||||||
| Other_sequence (112) | |||||||||
| Associated_feature | WBsf655144 | ||||||||
| WBsf662281 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00014141 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00111652 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00046001 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00106362 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00078330 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00076363 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00031614 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00066128 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00008087 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr4779 | ||||||||
| Expr5924 | |||||||||
| Expr16141 | |||||||||
| Expr1018568 | |||||||||
| Expr1030856 | |||||||||
| Expr1149900 | |||||||||
| Expr2011800 | |||||||||
| Expr2030038 | |||||||||
| Drives_construct | WBCnstr00002447 | ||||||||
| WBCnstr00012239 | |||||||||
| WBCnstr00036954 | |||||||||
| Construct_product | WBCnstr00036954 | ||||||||
| Microarray_results (21) | |||||||||
| Expression_cluster (155) | |||||||||
| Interaction (91) | |||||||||
| Map_info | Map | V | Position | 25.4031 | Error | 0.014716 | |||
| Positive | Positive_clone | F31D4 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference (13) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
