WormBase Tree Display for Gene: WBGene00001487
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| WBGene00001487 | SMap | S_parent | Sequence | T04B2 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | frk-1 | Person_evidence | WBPerson575 | |||||
| Sequence_name | T04B2.2 | ||||||||
| Molecular_name | T04B2.2a | ||||||||
| T04B2.2a.1 | |||||||||
| CE03609 | |||||||||
| T04B2.2a.2 | |||||||||
| T04B2.2b | |||||||||
| T04B2.2c | |||||||||
| Other_name | CELE_T04B2.2 | Accession_evidence | NDB | BX284604 | |||||
| Public_name | frk-1 | ||||||||
| DB_info | Database (13) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:24 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | frk | ||||||||
| Allele (33) | |||||||||
| Legacy_information | frk-1 stands for fer-related kinase (this gene is a member of the fes/fps family of non-receptor tyrosine kinases of which the human homolog, fer, is a member as well) | ||||||||
| Strain | WBStrain00035871 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (42) | |||||||||
| Ortholog (42) | |||||||||
| Paralog (59) | |||||||||
| Structured_description | Concise_description | frk-1 encodes a non-receptor tyrosine kinase orthologous to the human proto-oncogene Fer; frk-1 is an essential gene required early for embryonic cell proliferation and later in embryonic epidermal cells for enclosure, morphogenesis and late stages of differentiation; FRK-1's role in embryonic development is independent of its kinase domain, and when expressed in cultured mammalian cells, FRK-1 disrupts cell adhesion; FRK-1 is initially expressed in all cells of the early embryo where it localizes to nuclei and points of cell-cell contact; later expression is seen in epithelial cells, body wall muscle, and the adult germline, including mature sperm; FRK-1 expression in epidermal cells requires activity of the ELT-1 GATA transcription factor, and FRK-1 localization to the plasma membrane requires PAT-3/Beta-integrin, JAC-1/p120 catenin, and HMP-2/Beta-catenin with which FRK-1 interacts in vitro. | Paper_evidence | WBPaper00026609 | |||||
| Curator_confirmed | WBPerson48 | ||||||||
| WBPerson1843 | |||||||||
| Date_last_updated | 04 May 2007 00:00:00 | ||||||||
| Automated_description | Enables beta-catenin binding activity and protein kinase activity. Involved in several processes, including embryonic body morphogenesis; negative regulation of canonical Wnt signaling pathway; and regulation of epidermal cell differentiation. Located in several cellular components, including cell-cell junction; nucleus; and plasma membrane. Expressed in several structures, including germ line; hermaphrodite gonad; hypodermis; intestine; and sperm. Human ortholog(s) of this gene implicated in esophagus squamous cell carcinoma; hepatocellular carcinoma; and lung adenocarcinoma. Is an ortholog of human FER (FER tyrosine kinase) and FES (FES proto-oncogene, tyrosine kinase). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:3748 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3657) | ||||
| DOID:3910 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3657) | ||||||
| DOID:684 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3657) | ||||||
| Molecular_info | Corresponding_CDS | T04B2.2a | |||||||
| Corresponding_CDS_history | T04B2.2b:wp243 | ||||||||
| Corresponding_transcript | T04B2.2b | ||||||||
| T04B2.2c | |||||||||
| T04B2.2a.1 | |||||||||
| T04B2.2a.2 | |||||||||
| Other_sequence (46) | |||||||||
| Associated_feature | WBsf228922 | ||||||||
| Experimental_info | RNAi_result (23) | ||||||||
| Expr_pattern | Expr3701 | ||||||||
| Expr12446 | |||||||||
| Expr12447 | |||||||||
| Expr1025217 | |||||||||
| Expr1030888 | |||||||||
| Expr1155979 | |||||||||
| Expr2011880 | |||||||||
| Expr2030118 | |||||||||
| Drives_construct | WBCnstr00021086 | ||||||||
| WBCnstr00036915 | |||||||||
| Construct_product | WBCnstr00036915 | ||||||||
| Antibody | WBAntibody00000861 | ||||||||
| WBAntibody00000862 | |||||||||
| Microarray_results (22) | |||||||||
| Expression_cluster (170) | |||||||||
| Interaction (162) | |||||||||
| WBProcess | WBbiopr:00000073 | ||||||||
| Map_info | Map | IV | Position | 4.4713 | Error | 0.000971 | |||
| Positive | Positive_clone | T04B2 | Author_evidence | Rothman JR | |||||
| Inferred_automatically | From sequence, transcript, pseudogene data | ||||||||
| Pseudo_map_position | |||||||||
| Reference (12) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
