WormBase Tree Display for Gene: WBGene00001518
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WBGene00001518 | SMap | S_parent | Sequence | F47D12 | |||
---|---|---|---|---|---|---|---|
Identity | Version | 2 | |||||
Name | CGC_name | gar-2 | Person_evidence | WBPerson32 | |||
Sequence_name | F47D12.1 | ||||||
Molecular_name (15) | |||||||
Other_name | acm-2 | Paper_evidence | WBPaper00027767 | ||||
From_analysis | WormAtlas | ||||||
CELE_F47D12.1 | Accession_evidence | NDB | BX284603 | ||||
Public_name | gar-2 | ||||||
DB_info | Database (11) | ||||||
Species | Caenorhabditis elegans | ||||||
History (2) | |||||||
Status | Live | ||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | gar | ||||||
Allele (131) | |||||||
Strain | WBStrain00003713 | ||||||
WBStrain00031470 | |||||||
WBStrain00022222 | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (37) | |||||||
Ortholog (32) | |||||||
Paralog (20) | |||||||
Structured_description | Concise_description | gar-2 encodes a novel, seven transmembrane-domain G protein-coupled acetylcholine receptor (AChR); when expressed in Xenopus oocytes treated with acetylcholine, GAR-2 is able to activate a mammalian G protein-activated inwardly rectifying K+ (GIRK1) channel, but not other channels, suggesting that GAR-2 couples to G proteins of the Gi family; pharmacological analyses indicate, however, that GAR-2 exhibits properties distinct from mammalian muscarinic AChRs; gar-2 is expressed from mid-embryogenesis through adulthood with expression seen in ciliated head neurons, ventral cord neurons, and the HSN (hermaphrodite-specific neuron). | Paper_evidence | WBPaper00004388 | |||
Curator_confirmed | WBPerson1843 | ||||||
Date_last_updated | 02 Nov 2006 00:00:00 | ||||||
Automated_description | Enables G protein-coupled acetylcholine receptor activity. Involved in G protein-coupled receptor signaling pathway; negative regulation of cholinergic synaptic transmission; and response to xenobiotic stimulus. Located in axon. Expressed in neurons. | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Molecular_info | Corresponding_CDS | F47D12.1a | |||||
F47D12.1b | |||||||
F47D12.1c | |||||||
F47D12.1d | |||||||
F47D12.1e | |||||||
Corresponding_CDS_history | F47D12.1c:wp275 | ||||||
Corresponding_transcript | F47D12.1a.1 | ||||||
F47D12.1b.1 | |||||||
F47D12.1c.1 | |||||||
F47D12.1d.1 | |||||||
F47D12.1e.1 | |||||||
Other_sequence | JI221387.1 | ||||||
Dviv_isotig26799 | |||||||
GO251308.1 | |||||||
JI465005.1 | |||||||
CBC06005_1 | |||||||
FK808445.1 | |||||||
Associated_feature (15) | |||||||
Experimental_info (7) | |||||||
Map_info | Map | III | Position | -1.39824 | Error | 0.002289 | |
Positive | Positive_clone | F47D12 | Inferred_automatically | From CDS info | |||
From sequence, transcript, pseudogene data | |||||||
Mapping_data | Multi_point | 4334 | |||||
4407 | |||||||
Pseudo_map_position | |||||||
Reference (31) | |||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||
[140610 pad] Gene was missing Acquires_merge Event history data so inferred from Acquires_merge tag. | |||||||
Method | Gene |