| WBGene00001518 | SMap | S_parent | Sequence | F47D12 |
|---|
| Identity | Version | 2 |
| | Name | CGC_name | gar-2 | Person_evidence | WBPerson32 |
| | | Sequence_name | F47D12.1 |
| | | Molecular_name (15) |
| | | Other_name | acm-2 | Paper_evidence | WBPaper00027767 |
| | | | | From_analysis | WormAtlas |
| | | | CELE_F47D12.1 | Accession_evidence | NDB | BX284603 |
| | | Public_name | gar-2 |
| | DB_info | Database (11) |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:24 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | | | 2 | 10 Jun 2014 12:12:12 | WBPerson1983 | Event | Acquires_merge | WBGene00043340 |
| | | Acquires_merge | WBGene00043340 |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | gar |
| | Allele (131) |
| | Strain | WBStrain00003713 |
| | | WBStrain00031470 |
| | | WBStrain00022222 |
| | RNASeq_FPKM (74) |
| | GO_annotation (37) |
| | Ortholog (32) |
| | Paralog (20) |
| | Structured_description | Concise_description | gar-2 encodes a novel, seven transmembrane-domain G protein-coupled acetylcholine receptor (AChR); when expressed in Xenopus oocytes treated with acetylcholine, GAR-2 is able to activate a mammalian G protein-activated inwardly rectifying K+ (GIRK1) channel, but not other channels, suggesting that GAR-2 couples to G proteins of the Gi family; pharmacological analyses indicate, however, that GAR-2 exhibits properties distinct from mammalian muscarinic AChRs; gar-2 is expressed from mid-embryogenesis through adulthood with expression seen in ciliated head neurons, ventral cord neurons, and the HSN (hermaphrodite-specific neuron). | Paper_evidence | WBPaper00004388 |
| | | | | Curator_confirmed | WBPerson1843 |
| | | | | Date_last_updated | 02 Nov 2006 00:00:00 |
| | | Automated_description | Enables G protein-coupled acetylcholine receptor activity. Involved in G protein-coupled receptor signaling pathway; negative regulation of cholinergic synaptic transmission; and response to xenobiotic stimulus. Located in axon. Expressed in neurons. | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Molecular_info | Corresponding_CDS | F47D12.1a |
| | | F47D12.1b |
| | | F47D12.1c |
| | | F47D12.1d |
| | | F47D12.1e |
| | Corresponding_CDS_history | F47D12.1c:wp275 |
| | Corresponding_transcript | F47D12.1a.1 |
| | | F47D12.1b.1 |
| | | F47D12.1c.1 |
| | | F47D12.1d.1 |
| | | F47D12.1e.1 |
| | Other_sequence | JI221387.1 |
| | | Dviv_isotig26799 |
| | | GO251308.1 |
| | | JI465005.1 |
| | | CBC06005_1 |
| | | FK808445.1 |
| | Associated_feature (15) |
| Experimental_info | RNAi_result (11) |
| | Expr_pattern | Chronogram723 |
| | | Expr1114 |
| | | Expr8178 |
| | | Expr8179 |
| | | Expr10067 |
| | | Expr1025714 |
| | | Expr1030913 |
| | | Expr1151485 |
| | | Expr2011945 |
| | | Expr2030182 |
| | Drives_construct | WBCnstr00004148 |
| | | WBCnstr00009595 |
| | | WBCnstr00009870 |
| | | WBCnstr00010085 |
| | | WBCnstr00013162 |
| | | WBCnstr00015039 |
| | | WBCnstr00036893 |
| | Construct_product | WBCnstr00001343 |
| | | WBCnstr00036893 |
| | Microarray_results (49) |
| | Expression_cluster | WBPaper00024970:GABAergic_neuron_specific |
| | | WBPaper00033065:cyc-1(RNAi)_upregulated |
| | | WBPaper00035211:age-1_vs_age-1_downregulated |
| | | WBPaper00035211:age-1_vs_N2_downregulated |
| | | WBPaper00036375:enriched_in_PVD_OLL |
| | | WBPaper00037682:sma-2_sma-4_upregulated |
| | | WBPaper00038061:aldicarb_downregulated |
| | | WBPaper00038061:aldicarb_upregulated |
| | | WBPaper00038438:D.coniospora_12hr_downregulated_RNAseq |
| | | WBPaper00038438:E.faecalis_24hr_upregulated_RNAseq |
| | | WBPaper00038438:E.faecalis_24hr_upregulated_TilingArray |
| | | WBPaper00038438:Harposporium_24hr_upregulated_RNAseq |
| | | WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray |
| | | WBPaper00038438:S.marcescens_24hr_upregulated_TilingArray |
| | | WBPaper00042194:nhr-114(RNAi)_downregulated |
| | | WBPaper00042215:wdr-23(tm1817)_upregulated |
| | | WBPaper00042561:smgl-1(RNAi)_upregulated |
| | | WBPaper00044037:eat-2_upregulated |
| | | WBPaper00044578:reduced-humidity_downregulated_microarray |
| | | WBPaper00044656:tatn-1(qd182)_upregulated |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00045417:128Q-huntingtin_downreglated |
| | | WBPaper00048923:Aging_regulated |
| | | WBPaper00048988:neuron_enriched |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049545:jmjd-3.1(+)_upregulated |
| | | WBPaper00049626:UNC-75_target |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050726:OsmoticStress_regulated_Food |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult |
| | | WBPaper00050990:GABAergic-neuron_expressed |
| | | WBPaper00050990:intestine_expressed |
| | | WBPaper00050990:NMDA-neuron_expressed |
| | | WBPaper00053184:sma-2(rax5)_upregulated |
| | | WBPaper00053184:sma-4(rax3)_upregulated |
| | | WBPaper00053302:zidovudine_72h_regulated |
| | | WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_L1_SMARTseq |
| | | WBPaper00053388:dauer_regulated_Cluster4 |
| | | WBPaper00054758:alg-1(gk204)_upregulated |
| | | WBPaper00055103:thoc-5(wy822)_upregulated |
| | | WBPaper00055334:DLC-1_interacting |
| | | WBPaper00055354:Psora-Allantoin_downregulated |
| | | WBPaper00055354:Rapamycin-Allantoin_downregulated |
| | | WBPaper00055354:Rapamycin-Metformin_downregulated |
| | | WBPaper00055354:Rifampicin-Allantoin_downregulated |
| | | WBPaper00055482:pmt-2(RNAi)_upregulated |
| | | WBPaper00055626:pry-1(mu38)_downregulated |
| | | WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047) |
| | | WBPaper00056161:male_enriched_siRNA |
| | | WBPaper00056284:ints-11(RNAi)_downregulated |
| | | WBPaper00056443:sek-1(km4)_upregulated |
| | | WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated |
| | | WBPaper00056855:his-72(uge40)_upregulated |
| | | WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C |
| | | WBPaper00058598:mex-1(or286)_upregulated |
| | | WBPaper00058598:mex-3(eu149)_upregulated |
| | | WBPaper00058598:sin-3(tm1276)_downregulated |
| | | WBPaper00058598:spn-4(tm291)_upregulated |
| | | WBPaper00058948:PA14_downregulated |
| | | WBPaper00059027:neuron-synapses_depleted |
| | | WBPaper00059421:daf-3(mgDf90)_downregulated |
| | | WBPaper00059471:EGL-43_interacting |
| | | WBPaper00059566:wdr-23(mac32)_upregulated |
| | | WBPaper00059664:srbc-48(ac23)_upregulated |
| | | WBPaper00059763:neuron_expressed |
| | | WBPaper00060459:bcat-1(RNAi)_upregulated |
| | | WBPaper00060661:sensory-neuron_enriched |
| | | WBPaper00060811:L1_vs_adult_upregulated_neural |
| | | WBPaper00061203:sin-3(tm1276)_upregulated |
| | | WBPaper00061203:spr-1(ok2144)_upregulated |
| | | WBPaper00061340:AIB |
| | | WBPaper00061340:AIY |
| | | WBPaper00061340:AVD |
| | | WBPaper00061340:hmc_and_homolog |
| | | WBPaper00061340:IL1 |
| | | WBPaper00061340:RIA |
| | | WBPaper00061340:RIM |
| | | WBPaper00061340:RMD |
| | | WBPaper00061340:SIB |
| | | WBPaper00061340:SMD |
| | | WBPaper00061479:hda-1(ne4752)_upregulated |
| | | WBPaper00061479:mep-1(ne4629)_upregulated |
| | | WBPaper00061527:rgs-2_11061-pde-1 |
| | | WBPaper00061651:AIB_enriched |
| | | WBPaper00061651:DA_enriched |
| | | WBPaper00061651:DB_enriched |
| | | WBPaper00061651:PDA_enriched |
| | | WBPaper00061651:RIV_enriched |
| | | WBPaper00061651:SMD_enriched |
| | | WBPaper00061651:VA_enriched |
| | | WBPaper00061651:VB_enriched |
| | | WBPaper00061995:mter-4(syb3662syb3403)_downregulated |
| | | WBPaper00062103:neuron_enriched |
| | | WBPaper00062159:hda-2(ok1479)_upregulated |
| | | WBPaper00062325:muscle_depleted_coding-RNA |
| | | WBPaper00062354:H.zoospora_6h_regulated |
| | | WBPaper00064088:Day-1-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064306:Agaro-oligosaccharides_upregulated |
| | | WBPaper00064494:postdauer_upregulated_AWA |
| | | WBPaper00064721:fasn-1(g14)_downregulated_starved |
| | | WBPaper00065096:25C_vs_20C_downregulated |
| | | WBPaper00065096:Day10_vs_Day1_downregulated |
| | | WBPaper00065581:hpk-1(pk1393)_upregulated |
| | | WBPaper00065749:Heat-Shock_downregulated_endu-2(tm4977) |
| | | WBPaper00065749:Heat-Shock_downregulated_N2 |
| | | WBPaper00065835:Day5_vs_Day1_downregulated |
| | | WBPaper00065841:6_0 |
| | | WBPaper00065841:6_1 |
| | | WBPaper00065841:6_2 |
| | | WBPaper00065841:6_3 |
| | | WBPaper00065841:14_0 |
| | | WBPaper00065841:14_1 |
| | | WBPaper00065841:14_2 |
| | | WBPaper00065841:22_0 |
| | | WBPaper00065841:32_0 |
| | | WBPaper00065841:49_0 |
| | | WBPaper00065841:52_0 |
| | | WBPaper00065841:61_0 |
| | | WBPaper00065841:65_0 |
| | | WBPaper00065841:72_0 |
| | | WBPaper00065841:76_0 |
| | | WBPaper00065841:87_0 |
| | | WBPaper00065841:97_0 |
| | | WBPaper00065841:98_0 |
| | | WBPaper00065841:109_0 |
| | | WBPaper00065841:111_0 |
| | | WBPaper00065841:115_0 |
| | | WBPaper00065841:117_0 |
| | | WBPaper00065841:119_0 |
| | | WBPaper00065841:120_0 |
| | | WBPaper00065841:123_0 |
| | | WBPaper00065841:130_0 |
| | | WBPaper00065841:134_0 |
| | | WBPaper00065841:140_0 |
| | | WBPaper00065841:146_0 |
| | | WBPaper00065993:glp-1(e2141)_upregulated |
| | | cgc4386_cluster_5_5 |
| | | cgc4386_cluster_6_5 |
| | | cgc4489_group_14 |
| | | cgc4489_group_18 |
| | | WBPaper00024671:AFD_AWB_vs_unsorted_upregulated |
| | | WBPaper00025141:unc-4::GFP_Enriched_Genes |
| | | WBPaper00025141:unc-4::GFP_Expressed_Genes |
| | | WBPaper00030839:Embryo_A_Class |
| | | WBPaper00030839:Embryo_Pan_Neuronal |
| | | WBPaper00030839:Larval_A_Class |
| | | WBPaper00030839:Larval_Pan_Neuronal |
| | | WBPaper00031003:0hr_muscle_depleted |
| | | WBPaper00031003:hlh_1_enriched |
| | | WBPaper00031003:total_muscle_depleted |
| | | WBPaper00031252:AIN-1_IP_enriched |
| | | WBPaper00031252:AIN-2_IP_enriched |
| | | WBPaper00031532:Larva_Pan_Neuronal_Enriched |
| | | WBPaper00034739:N2moreDR1350 |
| | | WBPaper00034757:up_by_oxidative_stress |
| | | WBPaper00035084:embryo_enriched_AIN-2_IP |
| | | WBPaper00035084:L1_enriched_AIN-2_IP |
| | | WBPaper00035084:L2_enriched_AIN-2_IP |
| | | WBPaper00035084:L3_enriched_AIN-2_IP |
| | | WBPaper00035084:L4_enriched_AIN-2_IP |
| | | WBPaper00040210:Chlorpyrifos_Diazinon_24C_regulated |
| | | WBPaper00040858:eQTL_age_regulated_aging |
| | | WBPaper00040858:eQTL_age_regulated_developing |
| | | WBPaper00040858:eQTL_regulated_aging |
| | | WBPaper00040858:eQTL_regulated_reproductive |
| | | WBPaper00040876:mir-35_downregulated |
| | | WBPaper00040985:AIN-2_asynchronous_muscle |
| | | WBPaper00041174:genotypic |
| | | WBPaper00041174:genotypic_prime |
| | | WBPaper00041939:EtBr-exposed_vs_UVC-exposed_51h |
| | | WBPaper00042236:flcn-1(ok975)_upregulated |
| | | WBPaper00042548:miRISC_enriched |
| | | WBPaper00045673:colistin_upregulated |
| | | WBPaper00047070:N2_starvation_upregulated |
| | | WBPaper00047070:xpa-1_UV_downregulated |
| | | WBPaper00048989:eat-2(ad465)_rapamycin_upregulated |
| | | WBPaper00056330:mrps-5(RNAi)_upregulated |
| | Interaction (5) |
| Map_info | Map | III | Position | -1.39824 | Error | 0.002289 |
| | Positive | Positive_clone | F47D12 | Inferred_automatically | From CDS info |
| | | | | | From sequence, transcript, pseudogene data |
| | Mapping_data | Multi_point | 4334 |
| | | | 4407 |
| | Pseudo_map_position |
| Reference (31) |
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission |
| | [140610 pad] Gene was missing Acquires_merge Event history data so inferred from Acquires_merge tag. |
| Method | Gene |
