| WBGene00001597 | SMap | S_parent | Sequence | T07F8 |
|---|
| Identity | Version | 1 |
| | Name | CGC_name | gld-3 | Person_evidence | WBPerson555 |
| | | Sequence_name | T07F8.3 |
| | | Molecular_name | T07F8.3a |
| | | | T07F8.3a.1 |
| | | | CE42163 |
| | | | T07F8.3b |
| | | | CE28652 |
| | | | T07F8.3b.1 |
| | | Other_name | CELE_T07F8.3 | Accession_evidence | NDB | BX284602 |
| | | Public_name | gld-3 |
| | DB_info | Database | AceView | gene | 2H427 |
| | | | WormQTL | gene | WBGene00001597 |
| | | | WormFlux | gene | WBGene00001597 |
| | | | NDB | locus_tag | CELE_T07F8.3 |
| | | | Panther | gene | CAEEL|WormBase=WBGene00001597|UniProtKB=Q95ZK7 |
| | | | | family | PTHR10627 |
| | | | NCBI | gene | 174174 |
| | | | RefSeq | protein | NM_063078.4 |
| | | | | | NM_063079.8 |
| | | | SwissProt | UniProtAcc | Q95ZK7 |
| | | | TREEFAM | TREEFAM_ID | TF353300 |
| | | | UniProt_GCRP | UniProtAcc | Q95ZK7 |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:25 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | gld |
| | Allele (53) |
| | Strain | WBStrain00022615 |
| | | WBStrain00022623 |
| | | WBStrain00022625 |
| | | WBStrain00003944 |
| | RNASeq_FPKM (74) |
| | GO_annotation (33) |
| | Ortholog (20) |
| | Paralog | WBGene00000246 | Caenorhabditis elegans | From_analysis | Panther |
| | | WBGene00007463 | Caenorhabditis elegans | From_analysis | Panther |
| | Structured_description | Concise_description | gld-3 encodes two KH domain-containing RNA-binding proteins, GLD-3L and GLD-3S, that are homologous to Drosophila Bicaudal-C; gld-3 activity is required for two aspects of germ line development: the sperm/oocyte and mitosis/meiosis decisions; in regulating the sperm/oocyte switch, GLD-3L acts by binding and negatively regulating FBF's regulatory interaction with the fem-3 3'UTR; in regulating the mitosis/meiosis decision, GLD-3 functions with GLD-2, the catalytic subunit of a poly (A) polymerase, and in parallel to GLD-1 and NOS-3, to positively regulate entry into meiosis as germ cells move away from the distal, mitotic region of the gonad; in contrast to the sperm/oocyte decision, gld-3 functions downstream of FBFs, which bind specifically to elements in the gld-3S 3'-UTR to regulate GLD-3 expression, in the mitosis/meiosis decision; gld-3 activity is also required for germline survival and early embryogenesis; GLD-3 is a cytoplasmic protein that is found in the early embryo and in the germline throughout development in both sexes; in the early embryo, GLD-3 is also seen in cytoplasmic particles, some of which are coincident with P granules. | Paper_evidence | WBPaper00005566 |
| | | | | | WBPaper00024407 |
| | | | | | WBPaper00028555 |
| | | | | Curator_confirmed | WBPerson1843 |
| | | | | Date_last_updated | 26 Apr 2007 00:00:00 |
| | | Automated_description | Enables polynucleotide adenylyltransferase activator activity and protein domain specific binding activity. Involved in several processes, including developmental process involved in reproduction; positive regulation of meiotic nuclear division; and vulval development. Located in P granule. Part of RNA-directed RNA polymerase complex. Expressed in germ line and in male. | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Molecular_info | Corresponding_CDS | T07F8.3a |
| | | T07F8.3b |
| | Corresponding_CDS_history | T07F8.3a:wp86 |
| | | T07F8.3a:wp187 |
| | | T07F8.3b:wp86 |
| | Corresponding_transcript | T07F8.3a.1 |
| | | T07F8.3b.1 |
| | Other_sequence | CBC03502_1 |
| | | CBC00759_1 |
| | | CJC14646_1 |
| | | CR09698 |
| | Associated_feature (13) |
| Experimental_info | RNAi_result (26) |
| | Expr_pattern | Expr2269 |
| | | Expr12329 |
| | | Expr1025390 |
| | | Expr1030958 |
| | | Expr1156387 |
| | | Expr2012088 |
| | | Expr2030324 |
| | Construct_product | WBCnstr00021259 |
| | Antibody | WBAntibody00000574 |
| | | WBAntibody00000575 |
| | | WBAntibody00001931 |
| | | WBAntibody00001934 |
| | Microarray_results (30) |
| | Expression_cluster | WBPaper00031040:TGF-beta_adult_downregulated |
| | | WBPaper00032031:DConiospora_upregulated_cDNA_24h |
| | | WBPaper00033065:cyc-1(RNAi)_downregulated |
| | | WBPaper00035269:cde-1_regulated |
| | | WBPaper00037950:AVE-neuron_L1-larva_expressed |
| | | WBPaper00037950:BAG-neuron_blastula-embryo_expressed |
| | | WBPaper00037950:BAG-neuron_embryo_enriched |
| | | WBPaper00037950:bodywall-muscle_L1-larva_expressed |
| | | WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed |
| | | WBPaper00037950:dopaminergic-neurons_L1-larva_expressed |
| | | WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed |
| | | WBPaper00037950:germline-precursors_blastula-embryo_expressed |
| | | WBPaper00037950:germline-precursors_embryo_enriched |
| | | WBPaper00037950:hypodermis_embryo_enriched |
| | | WBPaper00037950:hypodermis_L1-larva_expressed |
| | | WBPaper00037950:hypodermis_L3-L4-larva_expressed |
| | | WBPaper00037950:intestine_L1-larva_expressed |
| | | WBPaper00037950:pharyngeal-muscle_embryo_enriched |
| | | WBPaper00037950:pharyngeal-muscle_L1-larva_expressed |
| | | WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed |
| | | WBPaper00038118:aak-2(gt33)_upregulated |
| | | WBPaper00044656:tatn-1(qd182)_downregulated |
| | | WBPaper00044736:rising_dev_expression |
| | | WBPaper00045420:fertilization_downregulated_transcript |
| | | WBPaper00045521:Gender_Neutral |
| | | WBPaper00045571:germline-ablation_downregulated |
| | | WBPaper00045774:clk-1_upregulated |
| | | WBPaper00046497:B.thuringiensis_0.1mix_downregulated_6h |
| | | WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h |
| | | WBPaper00046497:B.thuringiensis_0.5mix_downregulated_6h |
| | | WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h |
| | | WBPaper00048611:MnCl2_downregulated |
| | | WBPaper00048762:FOG-3_associated |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049498:npr-1(ur89)_regulated_3 |
| | | WBPaper00049905:Age_variant_expression |
| | | WBPaper00049920:Glucose-Diet_downregulated_hyl-2(tm2031) |
| | | WBPaper00049942:HeatShock_upregulated_hsf-1(RNAi) |
| | | WBPaper00049942:hsf-1(RNAi)_upregulated |
| | | WBPaper00050412:cco-1(RNAi)_upregulated_N2 |
| | | WBPaper00050488:20C_vs_25C_regulated_mir-34(OverExpression)_adult |
| | | WBPaper00050488:20C_vs_25C_regulated_N2_adult |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C |
| | | WBPaper00050522:mafr-1(tm6082)_downregulated |
| | | WBPaper00050859:downregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050859:downregulated_P-granule(-)GFP(-)_vs_control_day1-adult |
| | | WBPaper00050859:downregulated_P-granule(-)GFP(-)_vs_control_day2-adult |
| | | WBPaper00050990:GABAergic-neuron_expressed |
| | | WBPaper00050990:hypodermis_expressed |
| | | WBPaper00051039:germline_enriched |
| | | WBPaper00051265:F4_hrde-1(tm1200)_upregulated |
| | | WBPaper00051265:F4_morc-1(tm6048)_upregulated |
| | | WBPaper00051310:LIN-41_interacting |
| | | WBPaper00052884:emb-4(hc60)_downregulated |
| | | WBPaper00053184:sma-2(rax5)_downregulated |
| | | WBPaper00053184:sma-4(rax3)_downregulated |
| | | WBPaper00053302:zidovudine_72h_regulated |
| | | WBPaper00053321:PGCs_enriched_NuGen |
| | | WBPaper00053388:dauer_regulated_Cluster2 |
| | | WBPaper00053599:female_vs_male_upregulated |
| | | WBPaper00053599:oocyte_vs_mitosis_downregulated |
| | | WBPaper00053606:N2_vs_elt-2(ca15);elt-7(tm840)_upregulated |
| | | WBPaper00053606:N2_vs_elt-2(ca15)_upregulated |
| | | WBPaper00053713:Pheromone-induced_postdauer_vs_control_upregulated |
| | | WBPaper00053713:Starvation-induced_postdauer_vs_control_downregulated |
| | | WBPaper00053814:25C_downregulated_PY79 |
| | | WBPaper00054191:H3.3(null)_L1_upregulated |
| | | WBPaper00055334:DLC-1_interacting |
| | | WBPaper00055354:eat-2(ad1116)_upregulated |
| | | WBPaper00055354:Metformin_downregulated |
| | | WBPaper00055354:Rapamycin-Allantoin_upregulated |
| | | WBPaper00055354:Rapamycin-Metformin_downregulated |
| | | WBPaper00055354:Rapamycin_upregulated |
| | | WBPaper00055354:Rifampicin_downregulated |
| | | WBPaper00055648:germline_expressed |
| | | WBPaper00055862:antimycin_damt-1(gk961032)_regulated |
| | | WBPaper00055971:nhl-2(ok818)_25C_upregulated |
| | | WBPaper00056034:pals-22(jy3)_downregulated |
| | | WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047) |
| | | WBPaper00056139:soil-microbiota_downregulated |
| | | WBPaper00056284:ints-5(RNAi)_downregulated |
| | | WBPaper00056290:hsp-6(mg585)_downregulated |
| | | WBPaper00056443:sek-1(km4)_downregulated |
| | | WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated |
| | | WBPaper00056826:hmc_biased |
| | | WBPaper00057041:spc-1(cas971)_upregulated |
| | | WBPaper00057041:unc-70(cas983)_upregulated |
| | | WBPaper00057154:HeatShock_downregulated_mRNA |
| | | WBPaper00057154:HeatShock_upregulated_miRNA-target |
| | | WBPaper00058598:mex-3(eu149)_downregulated |
| | | WBPaper00058598:sin-3(tm1276)_upregulated |
| | | WBPaper00058691:sin-3(tm1276)_upregulated |
| | | WBPaper00058725:sftb-1(cer6)_downregulated |
| | | WBPaper00058725:sftb-1(cer39)_downregulated |
| | | WBPaper00058886:anp-1(ok608)_downregulated |
| | | WBPaper00059027:neuron-synapses_enriched |
| | | WBPaper00059174:MEG-3_interacting |
| | | WBPaper00059605:MUT-16_interacting |
| | | WBPaper00059664:srbc-48(ac23)_downregulated |
| | | WBPaper00060014:set-2(tm1630)_upregulated |
| | | WBPaper00060278:atp-2(RNAi)_upregulated |
| | | WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi) |
| | | WBPaper00060358:B.thuringiensis_pathogen_regulated_N2 |
| | | WBPaper00060445:ikb-1(nr2027)_upregulated_L4 |
| | | WBPaper00060445:nfki-1(cer1)_ikb-1(nr2027)_upregulated_L4 |
| | | WBPaper00060445:nfki-1(cer1)_upregulated_L4 |
| | | WBPaper00060459:bcat-1(RNAi)_downregulated |
| | | WBPaper00060661:sensory-neuron_depleted |
| | | WBPaper00060683:hlh-11(ko1)_downregulated |
| | | WBPaper00060811:L1_vs_adult_downregulated_neural |
| | | WBPaper00060909:atfs-1(cmh15)_upregulated |
| | | WBPaper00060909:atfs-1(et18)_upregulated |
| | | WBPaper00061007:S.aquatilis_downregulated |
| | | WBPaper00061203:sin-3(tm1276)_downregulated |
| | | WBPaper00061203:spr-1(ok2144)_downregulated |
| | | WBPaper00061274:hypergravity_15xg_upregulated |
| | | WBPaper00061274:microgravity_upregulated |
| | | WBPaper00061340:Germline |
| | | WBPaper00061439:unc-30(ok613)_downregulated |
| | | WBPaper00061439:unc-30(ok613)_downregulated_P.aeruginosa-infection |
| | | WBPaper00061466:nath-10(icb102)_upregulated |
| | | WBPaper00061527:C41G7.3_2766-ani-2_2946 |
| | | WBPaper00061527:daf-18_2911-ced-2_4092 |
| | | WBPaper00061527:let-99_22121-B0238.9_11154 |
| | | WBPaper00062123:GLH-1_interacting |
| | | WBPaper00062159:hda-2(ok1479)_downregulated |
| | | WBPaper00062325:muscle_depleted_coding-RNA |
| | | WBPaper00062440:crh-1(n3315)_upregulated |
| | | WBPaper00064005:starvation_downregulated_aptf-1(gk794)_mRNA |
| | | WBPaper00064071:NHR-49_interacting |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_glp-1(e2141) |
| | | WBPaper00064088:Day-1-adult_vs_L4_upregulated_fem-3(q20) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064088:Day-3-adult_vs_L4_upregulated_fem-3(q20) |
| | | WBPaper00064229:B.thuringiensis-Cry5Ba_downregulated |
| | | WBPaper00064403:Heat-killed-E.Coli_upregulated |
| | | WBPaper00064716:paraquat_upregulated |
| | | WBPaper00064871:hypoxia_upregulated_F1 |
| | | WBPaper00065096:25C_vs_20C_upregulated |
| | | WBPaper00065096:Day10_vs_Day1_upregulated |
| | | WBPaper00065258:anchor-cell_depleted |
| | | WBPaper00065373:Cisplatin_upregulated_WT |
| | | WBPaper00065975:P-body_vs_WholeAnimal_enriched |
| | | WBPaper00065984:pals-17(syb3980)_upregulated |
| | | WBPaper00065993:glp-1(e2141)_downregulated |
| | | WBPaper00066110:Doxorubicin_downregulated_diploid |
| | | WBPaper00066110:tetraploid_vs_diploid_downregulated |
| | | WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14 |
| | | WBPaper00025032:cluster_6 |
| | | WBPaper00026929:Resveratrol_regulated_daf-16 |
| | | WBPaper00026929:sir-2.1_overexpression_regulated |
| | | WBPaper00028948:cep-1(gk138)+UV_upregulated |
| | | WBPaper00030985:Enterococcus_faecalis_downregulated |
| | | WBPaper00030985:Serratia_marcesens_upregulated |
| | | WBPaper00031252:AIN-1_IP_enriched |
| | | WBPaper00032948:FedUp |
| | | WBPaper00034661:AgNPs_downregulated |
| | | WBPaper00035084:L2_enriched_AIN-2_IP |
| | | WBPaper00035873:dpy-9_regulated |
| | | WBPaper00035873:dpy-10_regulated |
| | | WBPaper00035905:FBF-1_Associated |
| | | WBPaper00036123:Atrazine_regulated |
| | | WBPaper00036123:Cadmium_regulated |
| | | WBPaper00036130:mir-243_down_regulated |
| | | WBPaper00037611:GLD-2-associated |
| | | WBPaper00037611:RNP-8-associated |
| | | WBPaper00037695:LD_3-day |
| | | WBPaper00037695:WC_5-day |
| | | WBPaper00037695:WC_CC_6-day |
| | | WBPaper00037901:GLD-1_mRNA_targets |
| | | WBPaper00040603:tdp-1(lf)_up_vs_N2_FC_1.2 |
| | | WBPaper00040858:eQTL_age_regulated_developing |
| | | WBPaper00040858:eQTL_regulated_developing |
| | | WBPaper00040858:eQTL_regulated_juvenile |
| | | WBPaper00040876:mir-35_upregulated |
| | | WBPaper00040963:TA300_down |
| | | WBPaper00041002:HF_3d_0.2mM_Down |
| | | WBPaper00041002:HF_3d_2.0mM_Down |
| | | WBPaper00041002:HF_11d_2.0mM_Up |
| | | WBPaper00041002:HQ_3d_2.0mM_Down |
| | | WBPaper00041606:CE_S.marcescens_regulated |
| | | WBPaper00041606:CE_X.nematophila_regulated |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_48h |
| | | WBPaper00041939:EtBr-exposed_vs_UVC-exposed_3h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h |
| | | WBPaper00045263:0.1mM-paraquat_upregulated |
| | | WBPaper00045263:nuo-6(qm200)_upregulated |
| | | WBPaper00045673:colistin_downregulated |
| | | WBPaper00046548:dafachronic-acid_downregulated |
| | | WBPaper00048989:eat-2(ad465)_rapamycin_upregulated |
| | | WBPaper00048989:N2_allantoin_upregulated |
| | | WBPaper00048989:N2_rapamycin_downregulated |
| | | WBPaper00051387:Triclosan_downregulated |
| | | WBPaper00055435:AuNPs_downregulated |
| | | WBPaper00056330:mrps-5(RNAi)_downregulated |
| | | [cgc5767]:expression_class_M |
| | | [cgc5767]:expression_class_SM |
| | | [cgc6390]:Cluster_E |
| | | [cgc6390]:intrinsic |
| | Interaction (112) |
| Map_info | Map | II | Position | 0.495502 | Error | 0.000121 |
| | Positive | Positive_clone | T07F8 | Inferred_automatically | From CDS info |
| | | | | | From sequence, transcript, pseudogene data |
| | Mapping_data | Multi_point | 4349 |
| | | | 4350 |
| | Pseudo_map_position |
| Reference (75) |
| Picture | WBPicture0000013095 |
| Remark | Sequence connection on the basis of PMID 12239571 [021008 ck1] |
| | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission |
| Method | Gene |
