WormBase Tree Display for Gene: WBGene00001609
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| WBGene00001609 | SMap | S_parent | Sequence | CHROMOSOME_III | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | glp-1 | Person_evidence | WBPerson320 | |||||
| Sequence_name | F02A9.6 | ||||||||
| Molecular_name | F02A9.6 | ||||||||
| F02A9.6.1 | |||||||||
| CE00237 | |||||||||
| Other_name | emb-33 | ||||||||
| CELE_F02A9.6 | Accession_evidence | NDB | BX284603 | ||||||
| Public_name | glp-1 | ||||||||
| DB_info | Database (12) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:25 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | glp | ||||||||
| Reference_allele | WBVar00240992 | ||||||||
| Allele (128) | |||||||||
| Possibly_affected_by | WBVar02153027 | ||||||||
| WBVar02153028 | |||||||||
| WBVar02158429 | |||||||||
| WBVar02158430 | |||||||||
| Legacy_information | g60ts mm : at 25x 100% eggs arrest at lima bean or earlier misplaced gut granule birefringence. Escapers have abnormal gonadogenesis. L1 temperature shift-up results in viable adult F1 Emb. At 16x viable. NA1. | ||||||||
| See also e2072, e2141, e2142, e2144 | |||||||||
| [C.elegansII] q46 : germ cells divide only a few times in both XX and XO forming 10-20 sperm; somatic gonad superficially wildtype. Mosaic analysis indicates germline focus. ES3 (adult). OA>10: q35, q50 (both have weaker phenotype than q46, some oocyte production, fertilized eggs arrest during embryogenesis);e2072 (Mel, late embryonic arrest, no AB derived pharyngeal cells, variable hypodermal defects),e2141ts, e2144ts (both Mel at 25C), g60ts,mm (pka emb-33, at 25C 100% eggs arrest at lima bean or earlier, misplaced gut granule birefringence. Escapers have abnormal gonadogenesis. L1 temperature shift-up results in viable adult F1 Emb. At 16C viable).Also gf alleles, q35sd (causes Muv, extra vulval differentiation, mimics lin-12(gf)); oz112gf (dominant germ line tumorous inboth sexes, some Muv, extra vulval differentiation).See also sog, ego, lag, lin-12 etc.; lag functions redundant with lin-12. Cloned: 4.4 kb transcripts, encodes 1295 aatransmembrane receptor, closely related to LIN-12, Drosophila Notch, etc.; extracellular 10 EGF-like repeats, other repeats; intracellular 6 ANK repeats, etc. Antibody staining indicates GLP-1 membrane-associated in early embryo, AB descendants, mitotic germ cells, not detected in gametes.Very extensive developmental and molecular analysis. [Austen and Kimble 1987, 1989; Priess et al. 1987; Yochem and Greenwald 1989; Crittenden et al. 1994; JK; BS; GE; JR; GS] | |||||||||
| Strain (260) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (52) | |||||||||
| Ortholog (50) | |||||||||
| Paralog | WBGene00000185 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WBGene00000792 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| WBGene00001148 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WBGene00003001 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Inparanoid_8 | |||||||||
| WormBase-Compara | |||||||||
| WBGene00019901 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WBGene00018041 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WBGene00012917 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WBGene00004963 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WBGene00021400 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| Structured_description | Concise_description | glp-1 encodes an N-glycosylated transmembrane protein that, along with LIN-12, comprises one of two C. elegans members of the LIN-12/Notch family of receptors; from the N- to the C-terminus, GLP-1 is characterized by ten extracellular EGF-like repeats, three LIN-12/Notch repeats, a CC-linker, a transmembrane domain, a RAM domain, six intracellular ankyrin repeats, and a PEST sequence; in C. elegans, GLP-1 activity is required for cell fate specification in germline and somatic tissues; in the germline, GLP-1, acting as a receptor for the DSL family ligand LAG-2, is essential for mitotic proliferation of germ cells and maintenance of germline stem cells; in somatic tissues, maternally provided GLP-1, acting as a receptor for the DSL family ligand APX-1, is required for inductive interactions that specify the fates of certain embryonic blastomeres; GLP-1 is also required for some later embryonic cell fate decisions, and in these decisions its activity is functionally redundant with that of LIN-12; GLP-1 expression is regulated temporally and spatially via translational control, as GLP-1 mRNA, present ubiquitously in the germline and embryo, yields detectable protein solely in lateral, interior, and endomembranes of distal, mitotic germ cells, and then predominantly in the AB blastomere and its descendants in the early embryo; proper spatial translation of glp-1 mRNA in the embryo is dependent upon genes such as the par genes, that are required for normal anterior-posterior asymmetry in the early embryo; signaling through GLP-1 controls the activity of the downstream Notch pathway components LAG-3 and LAG-1, the latter being predicted to function as part of a transcriptional feedback mechanism that positively regulates GLP-1 expression; signaling through the DNA-binding protein LAG-1 is believed to involve a direct interaction between LAG-1 and the GLP-1 RAM and ankyrin domains | Paper_evidence | WBPaper00001007 | |||||
| WBPaper00001008 | |||||||||
| WBPaper00002045 | |||||||||
| WBPaper00002479 | |||||||||
| WBPaper00002638 | |||||||||
| WBPaper00002654 | |||||||||
| WBPaper00002730 | |||||||||
| WBPaper00004520 | |||||||||
| WBPaper00005695 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 30 Jul 2004 00:00:00 | ||||||||
| Automated_description | Enables RNA polymerase II-specific DNA-binding transcription factor binding activity and transcription coactivator activity. Involved in several processes, including cytoplasmic streaming; positive regulation of cell population proliferation; and regulation of gene expression. Located in cytoplasm; endomembrane system; and lateral plasma membrane. Part of RNA polymerase II transcription regulator complex. Expressed in several structures, including AB lineage cell; anus; germ line; neurons; and somatic nervous system. Used to study cancer and obesity. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); and hematologic cancer (multiple). Is an ortholog of several human genes including NOTCH1 (notch receptor 1); NOTCH2 (notch receptor 2); and NOTCH3 (notch receptor 3). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:162 | Homo sapiens | Paper_evidence | WBPaper00046966 | ||||
| WBPaper00060633 | |||||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 24 Jun 2021 00:00:00 | ||||||||
| DOID:9970 | Homo sapiens | Paper_evidence | WBPaper00061889 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 28 Jun 2022 00:00:00 | ||||||||
| Potential_model (23) | |||||||||
| Models_disease_in_annotation | WBDOannot00000350 | ||||||||
| WBDOannot00001256 | |||||||||
| Models_disease_asserted | WBDOannot00000951 | ||||||||
| WBDOannot00000952 | |||||||||
| WBDOannot00000953 | |||||||||
| WBDOannot00000956 | |||||||||
| WBDOannot00000957 | |||||||||
| WBDOannot00000960 | |||||||||
| WBDOannot00000963 | |||||||||
| WBDOannot00000964 | |||||||||
| Molecular_info | Corresponding_CDS | F02A9.6 | |||||||
| Corresponding_transcript | F02A9.6.1 | ||||||||
| Other_sequence | CRC02162_1 | ||||||||
| CR05082 | |||||||||
| CBC01038_1 | |||||||||
| CRC03670_1 | |||||||||
| CR05539 | |||||||||
| Associated_feature (23) | |||||||||
| Experimental_info | RNAi_result (62) | ||||||||
| Expr_pattern (23) | |||||||||
| Drives_construct (11) | |||||||||
| Construct_product (14) | |||||||||
| Regulate_expr_cluster (12) | |||||||||
| Antibody (12) | |||||||||
| Microarray_results (19) | |||||||||
| Expression_cluster (168) | |||||||||
| Interaction (882) | |||||||||
| WBProcess | WBbiopr:00000001 | ||||||||
| WBbiopr:00000017 | |||||||||
| WBbiopr:00000032 | |||||||||
| WBbiopr:00000072 | |||||||||
| Map_info | Map | III | Position | 0.163759 | Error | 0.002428 | |||
| Well_ordered | |||||||||
| Positive | Positive_clone | F02A9 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| GS#L162 | |||||||||
| Negative | Outside_rearr | tnDf2 | |||||||
| Mapping_data | 2_point | 592 | |||||||
| 593 | |||||||||
| Multi_point (12) | |||||||||
| Pos_neg_data | 4714 | ||||||||
| 8636 | |||||||||
| 9452 | |||||||||
| Reference (900) | |||||||||
| Remark | yk9h8.5,yk9h8.3 removed from sequence list sdm 11/00 | ||||||||
| Method | Gene |
