WormBase Tree Display for Gene: WBGene00001648
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| WBGene00001648 | SMap | S_parent | Sequence | C26C6 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | goa-1 | Person_evidence | WBPerson625 | |||||
| Sequence_name | C26C6.2 | ||||||||
| Molecular_name | C26C6.2 | ||||||||
| C26C6.2.1 | |||||||||
| CE05311 | |||||||||
| Other_name | unc-109 | Paper_evidence | WBPaper00050947 | ||||||
| CELE_C26C6.2 | Accession_evidence | NDB | BX284601 | ||||||
| Public_name | goa-1 | ||||||||
| DB_info | Database | AceView | gene | 1I101 | |||||
| WormQTL | gene | WBGene00001648 | |||||||
| WormFlux | gene | WBGene00001648 | |||||||
| NDB | locus_tag | CELE_C26C6.2 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00001648|UniProtKB=P51875 | |||||||
| family | PTHR10218 | ||||||||
| NCBI | gene | 172505 | |||||||
| RefSeq | protein | NM_059707.6 | |||||||
| SwissProt | UniProtAcc | P51875 | |||||||
| UniProt_GCRP | UniProtAcc | P51875 | |||||||
| OMIM | gene | 139311 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:25 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| 2 | 06 Apr 2017 08:54:22 | WBPerson2970 | Event | Acquires_merge | WBGene00006834 | ||||
| Name_change | Other_name | unc-109 | |||||||
| Acquires_merge | WBGene00006834 | ||||||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | goa | ||||||||
| Allele (65) | |||||||||
| Possibly_affected_by | WBVar02157216 | ||||||||
| WBVar02157217 | |||||||||
| WBVar02157218 | |||||||||
| Legacy_information | [Hajdu-Cronin YM] sy192 hyperactive, abnormal male mating efficiency. | ||||||||
| [C.elegansII] sy192 : hyperactive, Egl-c, defective male mating OA3: pk39 (Tc1 insertion, similar phenotypes),n363, n1134 (some axon guidance defects ?) Cloned: encodes homolog of mammalian G protein alpha subunit (>80% identity). goa-1:lacZ expressed in most neurons,some muscle cells, pharynx, distal tip cells. Transgene overexpression leads to lethargy,slow pumping, egg-laying defects, irregular defecation. [Mendel et al. 1995; Segalat et al. 1995; KP; PS] | |||||||||
| n499dm : recessive lethal; n499/+ is uncoordinated | |||||||||
| See also n499 | |||||||||
| [C.elegansII] n499dm : recessive lethal, embryonic arrest; n499/+is uncoordinated, paralysed, muscle defective. ES3. NA1. [Park and Horvitz 1986a] | |||||||||
| Strain (18) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (65) | |||||||||
| Ortholog (67) | |||||||||
| Paralog (21) | |||||||||
| Structured_description | Concise_description | goa-1 encodes an ortholog of the heterotrimeric G protein alpha subunit Go (Go/Gi class); GOA-1 activity is required for regulation of a number of behaviors, including locomotion, egg-laying, male mating, and olfactory-mediated behaviors; GOA-1 activity is also required for asymmetric cell division in the early embryo; goa-1 genetically interacts with the egl-30 pathway, and is expressed in all neurons and sex-specific muscles; GOA-1 physically interacts with RIC-8 and AGS-3, and its activity is modulated by RIC-8 and RGS-7 in in vitro assays. | Paper_evidence | WBPaper00002142 | |||||
| WBPaper00004576 | |||||||||
| WBPaper00004721 | |||||||||
| WBPaper00024480 | |||||||||
| WBPaper00024481 | |||||||||
| WBPaper00027044 | |||||||||
| WBPaper00040078 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 19 Aug 2011 00:00:00 | ||||||||
| Automated_description | Enables several functions, including G protein activity; G protein-coupled acetylcholine receptor activity; and GTP binding activity. Involved in several processes, including detection of cold stimulus involved in thermoception; negative regulation of cholinergic synaptic transmission; and response to monoamine. Located in cell cortex. Expressed in several structures, including neurons; non-striated muscle; pharynx; spermatheca; and vulva. Used to study developmental and epileptic encephalopathy and early infantile epileptic encephalopathy. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 17 and neurodevelopmental disorder with involuntary movements. Is an ortholog of human GNAO1 (G protein subunit alpha o1). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:0050709 | Homo sapiens | Paper_evidence | WBPaper00061915 | ||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 20 Jan 2022 00:00:00 | ||||||||
| DOID:0112202 | Homo sapiens | Paper_evidence | WBPaper00062031 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 04 Feb 2022 00:00:00 | ||||||||
| Potential_model | DOID:0080450 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:4389) | |||||
| DOID:0112276 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:4389) | ||||||
| Models_disease_asserted | WBDOannot00001090 | ||||||||
| WBDOannot00001091 | |||||||||
| WBDOannot00001092 | |||||||||
| WBDOannot00001093 | |||||||||
| WBDOannot00001094 | |||||||||
| WBDOannot00001098 | |||||||||
| WBDOannot00001099 | |||||||||
| WBDOannot00001100 | |||||||||
| WBDOannot00001106 | |||||||||
| WBDOannot00001107 | |||||||||
| Molecular_info | Corresponding_CDS | C26C6.2 | |||||||
| Corresponding_transcript | C26C6.2.1 | ||||||||
| Other_sequence (61) | |||||||||
| Associated_feature (19) | |||||||||
| Experimental_info | RNAi_result (32) | ||||||||
| Expr_pattern (17) | |||||||||
| Drives_construct (12) | |||||||||
| Construct_product (11) | |||||||||
| Antibody | WBAntibody00000782 | ||||||||
| WBAntibody00000789 | |||||||||
| WBAntibody00001004 | |||||||||
| WBAntibody00001370 | |||||||||
| WBAntibody00001627 | |||||||||
| Microarray_results (24) | |||||||||
| Expression_cluster (139) | |||||||||
| Interaction (380) | |||||||||
| Anatomy_function | WBbtf0041 | ||||||||
| WBbtf0182 | |||||||||
| WBbtf0183 | |||||||||
| WBbtf0576 | |||||||||
| WBbtf0989 | |||||||||
| WBProcess | WBbiopr:00000017 | ||||||||
| WBbiopr:00000039 | |||||||||
| WBbiopr:00000120 | |||||||||
| Map_info | Map | I | Position | 2.09878 | Error | 0.001563 | |||
| Well_ordered | |||||||||
| Positive | Positive_clone | C26C6 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| PS#21D12 | |||||||||
| Mapping_data | Multi_point | 3230 | |||||||
| 3231 | |||||||||
| 5023 | |||||||||
| 5547 | |||||||||
| Reference (359) | |||||||||
| Picture | WBPicture0000013094 | ||||||||
| Method | Gene |
