gop-3 encodes an ortholog of the mammalian CGI-51 (comparative gene identification-51) proteins that display a high degree of similarity to the Haemophilus influenza D15 protective surface antigen; loss of gop-3 activity via large-scale RNAi screens indicates that GOP-3 is required for embryonic and larval development, as well as for normal postembryonic growth rates.
Predicted to be involved in mitochondrial respiratory chain complex assembly and protein insertion into mitochondrial outer membrane. Predicted to be located in mitochondrial outer membrane. Human ortholog(s) of this gene implicated in non-alcoholic fatty liver disease. Is an ortholog of human SAMM50 (SAMM50 sorting and assembly machinery component).
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.