WormBase Tree Display for Gene: WBGene00001674
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| WBGene00001674 | SMap | S_parent | Sequence | F18G5 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | gpa-12 | Person_evidence | WBPerson625 | |||||
| Sequence_name | F18G5.3 | ||||||||
| Molecular_name | F18G5.3 | ||||||||
| F18G5.3.1 | |||||||||
| CE20692 | |||||||||
| F18G5.3.2 | |||||||||
| Other_name | CELE_F18G5.3 | Accession_evidence | NDB | BX284606 | |||||
| Public_name | gpa-12 | ||||||||
| DB_info | Database | AceView | gene | XJ867 | |||||
| WormQTL | gene | WBGene00001674 | |||||||
| WormFlux | gene | WBGene00001674 | |||||||
| NDB | locus_tag | CELE_F18G5.3 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00001674|UniProtKB=Q19572 | |||||||
| family | PTHR10218 | ||||||||
| NCBI | gene | 181157 | |||||||
| RefSeq | protein | NM_077156.7 | |||||||
| SwissProt | UniProtAcc | Q19572 | |||||||
| UniProt_GCRP | UniProtAcc | Q19572 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:25 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | gpa | ||||||||
| Allele (77) | |||||||||
| Strain | WBStrain00028911 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (25) | |||||||||
| Ortholog (37) | |||||||||
| Paralog (21) | |||||||||
| Structured_description | Concise_description | gpa-12 encodes a member of the G protein alpha subunit family of heterotrimeric GTPases that is orthologous to members of the mammalian Galpha G12/G13 family; GPA-12 activity is required for antifungal innate immunity and genetic analyses indicate that GPA-12 functions upstream of phospholipase Cs PLC-3 and EGL-8 as well as the TPA-1 protein kinase C in this process; genetic analyses also suggest that gpa-12 functions upstream of tpa-1 in pathways that regulated feeding and growth; gpa-12 is expressed in the pharynx and in the hypodermis. | Paper_evidence | WBPaper00033094 | |||||
| WBPaper00003465 | |||||||||
| WBPaper00005783 | |||||||||
| Curator_confirmed | WBPerson48 | ||||||||
| WBPerson1843 | |||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 07 Jun 2013 00:00:00 | ||||||||
| Automated_description | Predicted to enable D5 dopamine receptor binding activity; G-protein beta/gamma-subunit complex binding activity; and GTPase activity. Involved in antifungal innate immune response and positive regulation of gene expression. Located in cytoplasm and nucleus. Expressed in several structures, including excretory cell; intestine; nerve ring; neurons; and pharynx. Is an ortholog of human GNA12 (G protein subunit alpha 12) and GNA13 (G protein subunit alpha 13). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | F18G5.3 | |||||||
| Corresponding_transcript | F18G5.3.1 | ||||||||
| F18G5.3.2 | |||||||||
| Other_sequence (31) | |||||||||
| Associated_feature | WBsf648405 | ||||||||
| Experimental_info | RNAi_result | WBRNAi00031110 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00013525 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00044968 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00063941 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00111937 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr1312 | ||||||||
| Expr2374 | |||||||||
| Expr2813 | |||||||||
| Expr2814 | |||||||||
| Expr2815 | |||||||||
| Expr1010324 | |||||||||
| Expr1030997 | |||||||||
| Expr1148938 | |||||||||
| Expr2012183 | |||||||||
| Expr2030419 | |||||||||
| Drives_construct | WBCnstr00010797 | ||||||||
| WBCnstr00010966 | |||||||||
| WBCnstr00010967 | |||||||||
| WBCnstr00036782 | |||||||||
| Construct_product (11) | |||||||||
| Microarray_results (19) | |||||||||
| Expression_cluster (114) | |||||||||
| Interaction (37) | |||||||||
| Anatomy_function | WBbtf0216 | ||||||||
| WBProcess | WBbiopr:00000039 | ||||||||
| Map_info | Map | X | Position | 0.932478 | Error | 0.021201 | |||
| Positive | Positive_clone | F18G5 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 4361 | |||||||
| 4378 | |||||||||
| 4774 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (43) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
