WormBase Tree Display for Gene: WBGene00001827

WBGene00001827 SMap: S_parent: Sequence: C46A5
  Identity: Version: 1
    Name: CGC_name: hcf-1
      Sequence_name: C46A5.9
      Molecular_name: C46A5.9
        C46A5.9.1
        CE26914
      Other_name: CELE_C46A5.9 Accession_evidence: NDB BX284604
      Public_name: hcf-1
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:25 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: hcf
    Allele (41)
    Strain: WBStrain00031490
      WBStrain00040638
    RNASeq_FPKM (74)
    GO_annotation (33)
    Contained_in_operon: CEOP4614
    Ortholog (44)
    Paralog: WBGene00009978 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00013461 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00021751 Caenorhabditis elegans From_analysis: WormBase-Compara
    Structured_description: Concise_description: hcf-1 encodes the C. elegans ortholog of human host cell factor (HCF-1), a transcriptional regulator that associates with histone modification enzymes and plays a role in cell cycle progression; in C. elegans, hcf-1 plays a role in regulation of cell division and mitotic histone modification; in addition, HCF-1 functions in determination of adult lifespan as a negative regulator of DAF-16, with which it physically interacts; HCF-1 is a ubiquitously expressed protein that localizes to the nucleus. Paper_evidence: WBPaper00031249
            WBPaper00032232
          Curator_confirmed: WBPerson1843
          Date_last_updated: 22 Dec 2009 00:00:00
      Automated_description: Enables RNA polymerase II-specific DNA-binding transcription factor binding activity; transcription coregulator activity; and transcription coregulator binding activity. Involved in several processes, including dauer exit; determination of adult lifespan; and regulation of DNA-templated transcription. Acts upstream of or within defense response to other organism and response to endoplasmic reticulum stress. Located in nucleus. Part of transcription regulator complex. Expressed widely. Human ortholog(s) of this gene implicated in methylmalonic acidemia and homocysteinemia cblX type. Is an ortholog of human HCFC1 (host cell factor C1) and HCFC2 (host cell factor C2). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0111814 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4839)
  Molecular_info: Corresponding_CDS: C46A5.9
    Corresponding_transcript: C46A5.9.1
    Other_sequence (31)
    Associated_feature: WBsf651947
      WBsf651948
      WBsf230320
  Experimental_info: RNAi_result: WBRNAi00088935 Inferred_automatically: RNAi_primary
      WBRNAi00042584 Inferred_automatically: RNAi_primary
      WBRNAi00081844 Inferred_automatically: RNAi_primary
      WBRNAi00108478 Inferred_automatically: RNAi_primary
      WBRNAi00081815 Inferred_automatically: RNAi_primary
      WBRNAi00062165 Inferred_automatically: RNAi_primary
      WBRNAi00081891 Inferred_automatically: RNAi_primary
      WBRNAi00012019 Inferred_automatically: RNAi_primary
      WBRNAi00081780 Inferred_automatically: RNAi_primary
      WBRNAi00108483 Inferred_automatically: RNAi_primary
    Expr_pattern (11)
    Drives_construct: WBCnstr00005314
      WBCnstr00009024
      WBCnstr00009025
      WBCnstr00036664
    Construct_product: WBCnstr00005314
      WBCnstr00009025
      WBCnstr00010947
      WBCnstr00036664
    Regulate_expr_cluster (17)
    Antibody: WBAntibody00000977
      WBAntibody00001472
    Microarray_results (22)
    Expression_cluster (152)
    Interaction: WBInteraction000051564
      WBInteraction000051599
      WBInteraction000051628
      WBInteraction000051667
      WBInteraction000121151
      WBInteraction000136993
      WBInteraction000142924
      WBInteraction000163132
      WBInteraction000174685
      WBInteraction000177696
      WBInteraction000177707
      WBInteraction000182558
      WBInteraction000183647
      WBInteraction000194099
      WBInteraction000209853
      WBInteraction000211837
      WBInteraction000216262
      WBInteraction000227481
      WBInteraction000231678
      WBInteraction000233813
      WBInteraction000237043
      WBInteraction000245441
      WBInteraction000247493
      WBInteraction000248891
      WBInteraction000252878
      WBInteraction000254783
      WBInteraction000255517
      WBInteraction000258171
      WBInteraction000261414
      WBInteraction000261482
      WBInteraction000264139
      WBInteraction000269061
      WBInteraction000269084
      WBInteraction000269926
      WBInteraction000271726
      WBInteraction000273551
      WBInteraction000278439
      WBInteraction000278650
      WBInteraction000283895
      WBInteraction000285735
      WBInteraction000287180
      WBInteraction000287231
      WBInteraction000288709
      WBInteraction000289204
      WBInteraction000290176
      WBInteraction000291538
      WBInteraction000293434
      WBInteraction000298172
      WBInteraction000302502
      WBInteraction000305482
      WBInteraction000306442
      WBInteraction000308629
      WBInteraction000310040
      WBInteraction000310440
      WBInteraction000313520
      WBInteraction000315673
      WBInteraction000316375
      WBInteraction000325048
      WBInteraction000330264
      WBInteraction000335457
      WBInteraction000340084
      WBInteraction000344218
      WBInteraction000345852
      WBInteraction000354244
      WBInteraction000359132
      WBInteraction000365162
      WBInteraction000366140
      WBInteraction000370444
      WBInteraction000372258
      WBInteraction000373517
      WBInteraction000374366
      WBInteraction000377285
      WBInteraction000378586
      WBInteraction000383721
      WBInteraction000386061
      WBInteraction000386695
      WBInteraction000388769
      WBInteraction000389019
      WBInteraction000392398
      WBInteraction000395935
      WBInteraction000399288
      WBInteraction000399443
      WBInteraction000400339
      WBInteraction000410795
      WBInteraction000413580
      WBInteraction000428748
      WBInteraction000429395
      WBInteraction000431002
      WBInteraction000432101
      WBInteraction000433135
      WBInteraction000437678
      WBInteraction000445247
      WBInteraction000458042
      WBInteraction000458049
      WBInteraction000459060
      WBInteraction000459582
      WBInteraction000461365
      WBInteraction000461517
      WBInteraction000518425
      WBInteraction000518488
      WBInteraction000539002
      WBInteraction000540852
      WBInteraction000543025
      WBInteraction000543052
      WBInteraction000543085
      WBInteraction000543086
      WBInteraction000549122
      WBInteraction000552156
      WBInteraction000556585
      WBInteraction000556586
      WBInteraction000559133
      WBInteraction000564648
      WBInteraction000564959
      WBInteraction000568877
      WBInteraction000573431
      WBInteraction000574501
      WBInteraction000574784
      WBInteraction000576550
    WBProcess: WBbiopr:00000001
  Map_info: Map: IV Position: 3.47224 Error: 0.000901
    Positive: Positive_clone: C46A5 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4397
        4935
    Pseudo_map_position
  Reference (32)
  Remark: Sequence connection from [Liu Y, Hengartner MO, Herr W]
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene