WormBase Tree Display for Gene: WBGene00001841

WBGene00001841 Evidence: CGC_data_submission
  SMap: S_parent: Sequence: C36B7
  Identity: Version: 1
    Name: CGC_name: hen-1 Person_evidence: WBPerson309
      Sequence_name: C36B7.7
      Molecular_name: C36B7.7
        C36B7.7.1
        CE04178
      Other_name: CELE_C36B7.7 Accession_evidence: NDB BX284606
      Public_name: hen-1
    DB_info: Database: AceView gene XH732
        WormQTL gene WBGene00001841
        WormFlux gene WBGene00001841
        NDB locus_tag CELE_C36B7.7
        Panther gene CAEEL|WormBase=WBGene00001841|UniProtKB=G5ECA8
          family PTHR21105
        NCBI gene 191666
        RefSeq protein NM_076799.7
        TREEFAM TREEFAM_ID TF318904
        TrEMBL UniProtAcc G5ECA8
        UniProt_GCRP UniProtAcc G5ECA8
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:25 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: hen
    Allele (200)
    Strain: WBStrain00022193
    RNASeq_FPKM (74)
    GO_annotation (11)
    Ortholog (11)
    Paralog: WBGene00020505 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
    Structured_description: Concise_description: hen-1 encodes a secreted protein that contains a low-density lipoprotein (LDL) receptor motif A; HEN-1 activity is required for integration of sensory stimuli and behavioral plasticity; a hen-1::GFP reporter is expressed in pharyngeal muscles, the vulva, and weakly in a subset of neurons; antibodies to HEN-1 protein detect expression exclusively in the AIY and ASE neurons, where HEN-1 appears to localize to cell bodies and in a punctate pattern in nerve ring axons at sites of synapse formation; HEN-1 expression in AIY appears to be under the control of the TTX-3 LIM domain transcription factor. Paper_evidence: WBPaper00004727
            WBPaper00005300
          Curator_confirmed: WBPerson48
            WBPerson1843
          Date_last_updated: 06 Nov 2007 00:00:00
      Automated_description: Predicted to enable transmembrane receptor protein tyrosine kinase activator activity. Involved in dauer larval development and nervous system process. Located in axon and neuronal cell body. Expressed in neurons; pharyngeal muscle cell; and vulva. Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: C36B7.7
    Corresponding_transcript: C36B7.7.1
  Experimental_info: RNAi_result: WBRNAi00042048 Inferred_automatically: RNAi_primary
      WBRNAi00011685 Inferred_automatically: RNAi_primary
      WBRNAi00029605 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr1911
      Expr1912
      Expr4411
      Expr1017068
      Expr1146048
      Expr2012397
      Expr2030633
      Marker48
    Drives_construct: WBCnstr00004840
      WBCnstr00010515
      WBCnstr00011976
      WBCnstr00036653
    Construct_product: WBCnstr00036653
    Antibody: WBAntibody00000523
    Microarray_results (17)
    Expression_cluster: WBPaper00031040:Cluster_5
      WBPaper00033065:clk-1(qm30)_upregulated
      WBPaper00033065:cyc-1(RNAi)_downregulated
      WBPaper00035211:age-1_vs_age-1_downregulated
      WBPaper00035211:age-1_vs_N2_downregulated
      WBPaper00037950:A-class-motor-neurons_L2-larva_expressed
      WBPaper00037950:all-neurons_L1-larva_expressed
      WBPaper00037950:all-neurons_larva_enriched
      WBPaper00037950:all-neurons_larva_SelectivelyEnriched
      WBPaper00037950:AVA-neuron_L1-larva_expressed
      WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed
      WBPaper00038438:D.coniospora_12hr_downregulated_RNAseq
      WBPaper00038438:E.faecalis_24hr_upregulated_RNAseq
      WBPaper00038438:Harposporium_24hr_upregulated_RNAseq
      WBPaper00038438:P.lumniescens_24hr_upregulated_RNAseq
      WBPaper00038438:S.marcescens_24hr_upregulated_RNAseq
      WBPaper00044005:DAF-16_upregulated
      WBPaper00044578:reduced-humidity_downregulated_microarray
      WBPaper00044736:flat_dev_expression
      WBPaper00045420:fertilization_downregulated_transcript
      WBPaper00045571:germline-ablation_upregulated
      WBPaper00045971:tunicamycin_upregulated_RtcB(null)
      WBPaper00047131:daf-2(e1370)_upregulated_N2-background
      WBPaper00047132:skn-1(RNAi)_downregulated
      WBPaper00048690:hermaphrodite-Z1-Z4-daughter_enriched
      WBPaper00048690:male-Z1-Z4-daughter_enriched
      WBPaper00048988:neuron_enriched
      WBPaper00048988:neuron_expressed
      WBPaper00049377:MWCNT_downregulated
      WBPaper00049635:dop-1(vs100)_downregulated
      WBPaper00049736:daf-2(e1370)_upregulated_15deg-then-25deg(12hr)
      WBPaper00050096:P.aeruginosa_downregulated
      WBPaper00050163:chd-3(eh4);let-418(RNAi)_downregulated_24-cell-embryo
      WBPaper00050163:chd-3(eh4);let-418(RNAi)_downregulated_100-cell-embryo
      WBPaper00050163:chd-3(eh4)_downregulated_24-cell-embryo
      WBPaper00050163:chd-3(eh4)_downregulated_100-cell-embryo
      WBPaper00050163:let-418(RNAi)_downregulated_24-cell-embryo
      WBPaper00050344:AFD-neuron_enriched
      WBPaper00050344:ASER-neuron_enriched
      WBPaper00050344:PLM-neuron_enriched
      WBPaper00050370:dpy-21(e428)_L3_upregulated
      WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C
      WBPaper00050561:indole_10-fold_downregulated
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050990:arcade_intestinal-valve_expressed
      WBPaper00050990:GABAergic-neuron_expressed
      WBPaper00053302:alovudine_72h_regulated
      WBPaper00053302:zidovudine_72h_regulated
      WBPaper00053318:Aging_upregulated_mRNA_N2
      WBPaper00053318:mir-71(n4115)_upregulated_mRNA
      WBPaper00053388:dauer_regulated_Cluster4
      WBPaper00055013:hmg-3(bar24)_upregulated
      WBPaper00055060:flr-1(RNAi)_downregulated
      WBPaper00055354:eat-2(ad1116)_downregulated
      WBPaper00055354:Psora-Allantoin_downregulated
      WBPaper00055354:Psora_downregulated
      WBPaper00055354:Rapamycin-Allantoin_downregulated
      WBPaper00055354:Rapamycin-Metformin_downregulated
      WBPaper00055354:Rapamycin-Psora-Allantoin_downregulated
      WBPaper00055354:Rapamycin-Psora_downregulated
      WBPaper00055354:Rapamycin-Rifampicin-Allantoin_downregulated
      WBPaper00055354:Rapamycin-Rifampicin-Psora_downregulated
      WBPaper00055354:Rapamycin-Rifampicin_downregulated
      WBPaper00055354:Rapamycin_downregulated
      WBPaper00055354:Rifampicin-Allantoin_downregulated
      WBPaper00055354:Rifampicin-Psora_downregulated
      WBPaper00055354:Rifampicin_downregulated
      WBPaper00055626:pry-1(mu38)_upregulated
      WBPaper00055827:daf-2(e1370)_upregulated
      WBPaper00055827:pfd-6(gk493446)_upregulated
      WBPaper00055971:nhl-2(ok818)_20C_upregulated
      WBPaper00055971:nhl-2(ok818)_25C_upregulated
      WBPaper00056284:ints-1(RNAi)_upregulated
      WBPaper00056550:ceh-60(ok1485)_downregulated_AdultDay1
      WBPaper00056550:ceh-60(ok1485)_downregulated_AdultDay4
      WBPaper00056826:SGP_biased
      WBPaper00057006:DietaryRestriction_downregulated
      WBPaper00057265:metaformin_downregulated_OP50
      WBPaper00057265:metaformin_downregulated_OP50-MR
      WBPaper00058598:mex-3(eu149)_upregulated
      WBPaper00058711:skn-1(lax188)_downregulated
      WBPaper00058948:PA14_downregulated
      WBPaper00059839:S.maltophilia_regulated
      WBPaper00060358:B.thuringiensis_non-pathogen_regulated_elt-2(RNAi)
      WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
      WBPaper00060459:bcat-1(RNAi)_upregulated
      WBPaper00060661:sensory-neuron_enriched
      WBPaper00060703:nas-38(ok3407)_upregulated
      WBPaper00061341:28C_24h_upregulated
      WBPaper00061341:28C_48h_upregulated
      WBPaper00061527:C17H12.6-swt-6
      WBPaper00061530:nhr-49(e2144)_downregulated
      WBPaper00061651:AFD_enriched
      WBPaper00061651:AIY_enriched
      WBPaper00061651:ASER_enriched
      WBPaper00061651:AWC_ON_enriched
      WBPaper00061651:RIC_enriched
      WBPaper00061651:RIR_enriched
      WBPaper00061952:daf-18(nr2037)_downregulated
      WBPaper00062103:neuron_enriched
      WBPaper00062184:PA14_upregulated
      WBPaper00062325:muscle_depleted_coding-RNA
      WBPaper00062590:Aging_upregulated_neuron
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_fem-3(q20)
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_fem-3(q20)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_glp-1(e2141)
      WBPaper00064716:paraquat_downregulated
      WBPaper00064769:him-17(me24)_upregulated
      WBPaper00065005:sams-3(RNAi)_upregulated
      WBPaper00065096:25C_vs_20C_downregulated
      WBPaper00065096:Day10_vs_Day1_upregulated
      WBPaper00065096:npr-8(ok1439)_upregulated_Day1_25C
      WBPaper00065258:anchor-cell_enriched
      WBPaper00065581:hpk-1(pk1393)_downregulated
      WBPaper00065749:endu-2(tm4977)_upregulated
      WBPaper00065749:Heat-Shock_downregulated_endu-2(tm4977)
      WBPaper00065841:35_1
      WBPaper00065841:35_2
      WBPaper00065841:35_3
      WBPaper00065841:35_4
      WBPaper00065841:48_0
      WBPaper00065841:106_0
      WBPaper00065841:112_0
      WBPaper00065975:P-body_vs_WholeAnimal_depleted
      WBPaper00065993:glp-1(e2141)_upregulated
      WBPaper00066118:cyclobutrifluram_downregulated
      WBPaper00066146:germline-inx-14(RNAi)_upregulated_PA14
      WBPaper00066232:hsf-1(RNAi)_upregulated_ash-2
      cgc4489_group_18
      WBPaper00005124:progesterone_10-7M_regulated
      WBPaper00025141:unc-4::GFP_Enriched_Genes
      WBPaper00025141:unc-4::GFP_Expressed_Genes
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00028789:PA14_vs_OP50_downregulated_8hr
      WBPaper00029437:dcr-1_upregulated
      WBPaper00030839:Embryo_A_Class
      WBPaper00030839:Larval_Pan_Neuronal
      WBPaper00031184:acrylamide_upregulated
      WBPaper00032062:age_regulated_genes
      WBPaper00035479:daf-16(RNAi)_downregulated
      WBPaper00036123:Cadmium_regulated
      WBPaper00036286:Pattern_D
      WBPaper00036464:S.aureus-RN6390_regulated
      WBPaper00037695:WC_5-day
      WBPaper00038462:aging_downregulated
      WBPaper00040858:eQTL_age_regulated_aging
      WBPaper00040858:eQTL_age_regulated_developing
      WBPaper00040858:eQTL_regulated_aging
      WBPaper00040858:eQTL_regulated_developing
      WBPaper00040858:eQTL_regulated_reproductive
      WBPaper00040963:TA200_down
      WBPaper00040963:TA300_down
      WBPaper00041002:HF_11d_0.2mM_Up
      WBPaper00044535:male_downregulated
      WBPaper00045263:nuo-6(qm200)_upregulated
      WBPaper00045294:50uM_DBAA_upregulated
      WBPaper00045673:colistin_upregulated
      WBPaper00045807:microcystin-LR_upregulated
      WBPaper00046853:AOBr_M.aeruginosa-batch-culture_upregulated
      WBPaper00048989:eat-2(ad465)_downregulated_in-DMSO
      WBPaper00050767:Octopamine_induced
      WBPaper00053550:daf-19(m86)_upregulated_AdultDay2
    Interaction (24)
    Anatomy_function: WBbtf0093
      WBbtf0094
      WBbtf0095
      WBbtf0096
      WBbtf0097
      WBbtf0098
      WBbtf0099
      WBbtf0100
  Map_info: Map: X Position: -1.85356 Error: 0.009919
    Positive: Positive_clone: C36B7 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4400
    Pseudo_map_position
  Reference (47)
  Remark: Sequence connection from [Katsura I]
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene