WormBase Tree Display for Gene: WBGene00001865

WBGene00001865 Evidence: CGC_data_submission
  SMap: S_parent: Sequence: T04A11
  Identity: Version: 1
    Name: CGC_name: him-6 Person_evidence: WBPerson261
      Sequence_name: T04A11.6
      Molecular_name: T04A11.6
        T04A11.6.1
        CE31724
      Other_name: blm-1
        CELE_T04A11.6 Accession_evidence: NDB BX284604
      Public_name: him-6
    DB_info: Database (13)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:25 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info (11)
  Disease_info: Experimental_model: DOID:2717 Homo sapiens Paper_evidence: WBPaper00013454
          Accession_evidence: OMIM 210900
          Curator_confirmed: WBPerson324
          Date_last_updated: 05 Jun 2017 00:00:00
    Potential_model: DOID:2717 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1058)
    Disease_relevance: Mutations in the human BLM gene (a RecQ family DNA helicase) are implicatd in Bloom syndrome, an inherited disorder characterized by short stature, increased sensitivity to sunlight, a greatly increased risk of cancer and infertility; at the cellular level it is characterized by genomic instability, in particular, hyperrecombination between sister chromatids and homologous chromosomes; the C. elegans BLM ortholog, him-6, exhibits DNA-dependent ATPase activity and mutants show an enhanced irradiation sensitivity, a partially defective S-phase checkpoint, and in reduced levels of DNA-damage induced apoptosis. Homo sapiens Paper_evidence: WBPaper00013454
          Accession_evidence: OMIM 604610
          Curator_confirmed: WBPerson324
          Date_last_updated: 05 Jun 2017 00:00:00
  Models_disease_asserted: WBDOannot00000132
    WBDOannot00000436
    WBDOannot00000437
    WBDOannot00000438
  Molecular_info: Corresponding_CDS: T04A11.6
    Corresponding_CDS_history: T04A11.6:wp84
    Corresponding_transcript: T04A11.6.1
    Other_sequence (32)
    Associated_feature: WBsf660814
      WBsf660815
      WBsf998136
      WBsf998137
      WBsf1018380
      WBsf1018381
      WBsf229300
  Experimental_info: RNAi_result: WBRNAi00008018 Inferred_automatically: RNAi_primary
      WBRNAi00075599 Inferred_automatically: RNAi_primary
      WBRNAi00052319 Inferred_automatically: RNAi_primary
      WBRNAi00018100 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr1024637
      Expr1031098
      Expr1155954
      Expr2012431
      Expr2030667
    Drives_construct: WBCnstr00036640
    Construct_product: WBCnstr00036640
    Antibody: WBAntibody00002533
    Microarray_results (20)
    Expression_cluster (125)
    Interaction (123)
  Map_info: Map: IV Position: 5.98937 Error: 0.002716
    Well_ordered
    Positive: Positive_clone: T04A11 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 111
        112
        113
        5281
        5470
      Pos_neg_data: 5444
        5445
        5446
        5447
  Reference: WBPaper00000179
    WBPaper00000565
    WBPaper00000608
    WBPaper00000983
    WBPaper00001168
    WBPaper00001399
    WBPaper00001462
    WBPaper00002023
    WBPaper00002339
    WBPaper00002403
    WBPaper00004349
    WBPaper00004757
    WBPaper00005100
    WBPaper00005486
    WBPaper00005638
    WBPaper00006268
    WBPaper00010013
    WBPaper00010459
    WBPaper00010535
    WBPaper00010644
    WBPaper00011548
    WBPaper00011726
    WBPaper00011743
    WBPaper00013454
    WBPaper00013698
    WBPaper00013934
    WBPaper00014382
    WBPaper00015329
    WBPaper00015479
    WBPaper00015922
    WBPaper00016304
    WBPaper00017230
    WBPaper00018294
    WBPaper00018422
    WBPaper00019088
    WBPaper00019733
    WBPaper00023215
    WBPaper00024765
    WBPaper00025412
    WBPaper00026827
    WBPaper00026934
    WBPaper00027172
    WBPaper00027223
    WBPaper00027275
    WBPaper00028759
    WBPaper00030838
    WBPaper00031857
    WBPaper00031945
    WBPaper00032410
    WBPaper00033816
    WBPaper00034402
    WBPaper00034417
    WBPaper00035505
    WBPaper00037751
    WBPaper00038491
    WBPaper00038960
    WBPaper00043242
    WBPaper00043946
    WBPaper00043947
    WBPaper00043987
    WBPaper00045509
    WBPaper00045518
    WBPaper00049394
    WBPaper00052037
    WBPaper00052345
    WBPaper00053104
    WBPaper00054686
    WBPaper00055090
    WBPaper00057253
    WBPaper00059317
    WBPaper00061201
    WBPaper00061254
    WBPaper00062238
    WBPaper00064114
  Remark: Sequence connection from [Wicky C, Muller F]
  Method: Gene