WormBase Tree Display for Gene: WBGene00001872
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| WBGene00001872 | SMap | S_parent | Sequence | ZK1127 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | him-14 | Person_evidence | WBPerson261 | |||||
| Sequence_name | ZK1127.11 | ||||||||
| Molecular_name | ZK1127.11 | ||||||||
| ZK1127.11.1 | |||||||||
| CE24714 | |||||||||
| Other_name | CELE_ZK1127.11 | Accession_evidence | NDB | BX284602 | |||||
| Public_name | him-14 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:26 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | him | ||||||||
| Reference_allele | WBVar00088021 | ||||||||
| Allele (44) | |||||||||
| Legacy_information | [C.elegansII] it44ts : viable self-progeny 2--40% male,95% dead eggs, probable generalized nondisjunction,meiotic defect. OA4: it13, it21, it23, it52 (strongest allele, <3% eggs hatch). [Kemphues et al. 1988] | ||||||||
| Strain | WBStrain00029021 | ||||||||
| WBStrain00023558 | |||||||||
| WBStrain00000291 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (21) | |||||||||
| Ortholog (34) | |||||||||
| Paralog | WBGene00003418 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| WBGene00003421 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00003422 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | him-14 encodes a germline-specific member of the MutS family of DNA mismatch repair (MMR) proteins that is orthologous to human MSH4 and Saccharomyces cerevisiae Msh4p; during the pachytene stage of meiosis, HIM-14 activity is required for promoting crossing over between homologous chromosomes and thus, for chiasmata formation and proper chromosome segregation; in contrast, HIM-14 activity does not appear to be required for mismatch repair, nor for chromosome pairing or synapsis; him-14 mRNA expression is detected exclusively in the germline. | Paper_evidence | WBPaper00001109 | |||||
| WBPaper00003779 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 18 Dec 2006 00:00:00 | ||||||||
| Automated_description | Predicted to enable double-stranded DNA binding activity. Involved in chiasma assembly; embryo development; and resolution of meiotic recombination intermediates. Located in nucleus. Expressed in embryonic cell and gonad. Human ortholog(s) of this gene implicated in primary ovarian insufficiency and spermatogenic failure 2. Is an ortholog of human MSH4 (mutS homolog 4). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:5426 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:7327) | ||||
| DOID:0070164 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:7327) | ||||||
| Molecular_info | Corresponding_CDS | ZK1127.11 | |||||||
| Corresponding_transcript | ZK1127.11.1 | ||||||||
| Other_sequence | CR07984 | ||||||||
| JI167587.1 | |||||||||
| CBC06908_1 | |||||||||
| CRC02643_1 | |||||||||
| Associated_feature | WBsf223282 | ||||||||
| WBsf223283 | |||||||||
| Experimental_info | RNAi_result (36) | ||||||||
| Expr_pattern | Expr12974 | ||||||||
| Expr1025657 | |||||||||
| Expr1031101 | |||||||||
| Expr1162552 | |||||||||
| Expr2012423 | |||||||||
| Expr2030659 | |||||||||
| Drives_construct | WBCnstr00001712 | ||||||||
| WBCnstr00020969 | |||||||||
| WBCnstr00036638 | |||||||||
| Construct_product | WBCnstr00036638 | ||||||||
| Microarray_results (21) | |||||||||
| Expression_cluster (136) | |||||||||
| Interaction (51) | |||||||||
| WBProcess | WBbiopr:00000099 | ||||||||
| Map_info | Map | II | Position | 0.475478 | Error | 0.021331 | |||
| Well_ordered | |||||||||
| Positive | Positive_clone | ZK1127 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | 2_point | 3787 | |||||||
| Multi_point | 1391 | ||||||||
| 4542 | |||||||||
| Pos_neg_data | 4475 | ||||||||
| Reference (40) | |||||||||
| Method | Gene |
