WormBase Tree Display for Gene: WBGene00001978
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WBGene00001978 | SMap | S_parent | Sequence | R13H4 | |||
---|---|---|---|---|---|---|---|
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | hmp | ||||||
Allele (102) | |||||||
Legacy_information | [C.elegansII] Mutations zygotic lethal, arrest at 1.25-1.5 fold stage with lumps in dorsal hypoderm. Cloned: encodes probable alpha-catenin homolog. [JJ] | ||||||
Strain | WBStrain00001826 | ||||||
WBStrain00022476 | |||||||
WBStrain00024213 | |||||||
WBStrain00030631 | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (27) | |||||||
Ortholog (47) | |||||||
Paralog | WBGene00000832 | Caenorhabditis elegans | From_analysis | TreeFam | |||
WormBase-Compara | |||||||
WBGene00000942 | Caenorhabditis elegans | From_analysis | TreeFam | ||||
WormBase-Compara | |||||||
Structured_description | Concise_description | hmp-1 encodes an alpha-catenin; during development, hmp-1 activity is required for proper enclosure and elongation of the embryo; HMP-1 localizes to hypodermal adherens junctions. | Paper_evidence | WBPaper00003046 | |||
Curator_confirmed | WBPerson1843 | ||||||
Date_last_updated | 11 Jun 2008 00:00:00 | ||||||
Automated_description | Enables actin filament binding activity and beta-catenin binding activity. Involved in several processes, including cortical actin cytoskeleton organization; embryonic morphogenesis; and regulation of actin cytoskeleton organization. Located in adherens junction and apical junction complex. Part of catenin complex. Expressed in several structures, including distal tip cell; germ cell; intestinal cell; neuroblasts; and pharyngeal cell. Human ortholog(s) of this gene implicated in several diseases, including arrhythmogenic right ventricular dysplasia 13; cervix uteri carcinoma in situ; and urinary system cancer (multiple). Is an ortholog of human CTNNA2 (catenin alpha 2). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info | Potential_model | DOID:8991 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2509) | ||
DOID:11054 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2509) | ||||
DOID:0090131 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2510) | ||||
DOID:2671 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2509) | ||||
DOID:0060864 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2509) | ||||
DOID:0110084 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2511) | ||||
DOID:4450 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2509) | ||||
DOID:10283 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2509) | ||||
DOID:3457 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2509) | ||||
Molecular_info | Corresponding_CDS | R13H4.4a | |||||
R13H4.4b | |||||||
R13H4.4c | |||||||
R13H4.4d | |||||||
R13H4.4e | |||||||
R13H4.4f | |||||||
Corresponding_transcript | R13H4.4a.1 | ||||||
R13H4.4b.1 | |||||||
R13H4.4c.1 | |||||||
R13H4.4d.1 | |||||||
R13H4.4e.1 | |||||||
R13H4.4f.1 | |||||||
R13H4.4f.2 | |||||||
Other_sequence (49) | |||||||
Associated_feature (11) | |||||||
Experimental_info | RNAi_result (18) | ||||||
Expr_pattern | Chronogram912 | ||||||
Expr6534 | |||||||
Expr9341 | |||||||
Expr13047 | |||||||
Expr14677 | |||||||
Expr1011130 | |||||||
Expr1031148 | |||||||
Expr1155584 | |||||||
Expr2012529 | |||||||
Expr2030768 | |||||||
Drives_construct | WBCnstr00002622 | ||||||
WBCnstr00004619 | |||||||
WBCnstr00006235 | |||||||
WBCnstr00007873 | |||||||
WBCnstr00008029 | |||||||
WBCnstr00009117 | |||||||
WBCnstr00020495 | |||||||
WBCnstr00036545 | |||||||
Construct_product | WBCnstr00020495 | ||||||
WBCnstr00036545 | |||||||
Antibody | WBAntibody00000167 | ||||||
WBAntibody00001450 | |||||||
WBAntibody00002691 | |||||||
Microarray_results (30) | |||||||
Expression_cluster (135) | |||||||
Interaction (117) | |||||||
WBProcess | WBbiopr:00000017 | ||||||
Map_info | Map | V | Position | 3.46447 | Error | 0.012439 | |
Positive | Positive_clone | R13H4 | Inferred_automatically | From sequence, transcript, pseudogene data | |||
Mapping_data | Multi_point | 4408 | |||||
5036 | |||||||
Pseudo_map_position | |||||||
Reference (108) | |||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||
Method | Gene |