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WormBase Tree Display for Gene: WBGene00002069

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Name Class

WBGene00002069SMapS_parentSequenceC04F12
IdentityVersion1
NameCGC_nameikb-1Person_evidenceWBPerson1122
Sequence_nameC04F12.3
Molecular_nameC04F12.3
C04F12.3.1
CE19676
Other_nameCELE_C04F12.3Accession_evidenceNDBBX284601
Public_nameikb-1
DB_infoDatabase (11)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:26WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classikb
Allele (53)
Possibly_affected_byWBVar02153293
StrainWBStrain00029112
WBStrain00051604
WBStrain00051846
RNASeq_FPKM (74)
GO_annotation00018666
00018667
00018668
00018669
00018670
00018671
00018672
00018673
00109966
Ortholog (33)
ParalogWBGene00006780Caenorhabditis elegansFrom_analysisPanther
WBGene00012124Caenorhabditis elegansFrom_analysisPanther
WBGene00011240Caenorhabditis elegansFrom_analysisPanther
WBGene00007252Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
Structured_descriptionConcise_descriptionikb-1 encodes an ortholog of human BCL3 (OMIM:109560) that physically interacts with the checkpoint protein MRT-2; ikb-1(nr2019) and ikb-1(nr2027) mutants display no obvious phenotype other than shortened lifespan; mutation of BCL3 is frequently associated with recurring translocations found in the neoplastic cells of patients with chronic lymphocytic leukemia, and has been implicated in cell cycle control (perhaps via apoptosis).Paper_evidenceWBPaper00004589
WBPaper00004692
WBPaper00005039
Curator_confirmedWBPerson567
Date_last_updated17 Jun 2004 00:00:00
Automated_descriptionPredicted to enable NF-kappaB binding activity. Involved in defense response to Gram-negative bacterium. Located in cytoplasm. Human ortholog(s) of this gene implicated in common variable immunodeficiency 10. Is an ortholog of human NFKB2 (nuclear factor kappa B subunit 2).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_modelDOID:0081152Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:7795)
Molecular_infoCorresponding_CDSC04F12.3
Corresponding_transcriptC04F12.3.1
Other_sequence (38)
Associated_featureWBsf643607
WBsf643608
WBsf656781
WBsf984774
WBsf984775
WBsf1010411
WBsf1010412
WBsf218325
Experimental_infoRNAi_resultWBRNAi00002902Inferred_automaticallyRNAi_primary
WBRNAi00114630Inferred_automaticallyRNAi_primary
WBRNAi00028440Inferred_automaticallyRNAi_primary
WBRNAi00039630Inferred_automaticallyRNAi_primary
WBRNAi00091427Inferred_automaticallyRNAi_primary
WBRNAi00075903Inferred_automaticallyRNAi_primary
WBRNAi00067972Inferred_automaticallyRNAi_primary
WBRNAi00001332Inferred_automaticallyRNAi_primary
Expr_patternExpr9563
Expr15289
Expr1026817
Expr1031222
Expr1143726
Expr2012714
Expr2030950
Drives_constructWBCnstr00036478
Construct_productWBCnstr00014128
WBCnstr00036478
Regulate_expr_clusterWBPaper00060445:ikb-1(nr2027)_downregulated_L1
WBPaper00060445:ikb-1(nr2027)_downregulated_L4
WBPaper00060445:ikb-1(nr2027)_upregulated_L1
WBPaper00060445:ikb-1(nr2027)_upregulated_L4
WBPaper00060445:nfki-1(cer1)_ikb-1(nr2027)_downregulated_L4
WBPaper00060445:nfki-1(cer1)_ikb-1(nr2027)_upregulated_L4
Microarray_results (19)
Expression_cluster (210)
InteractionWBInteraction000007426
WBInteraction000028640
WBInteraction000029880
WBInteraction000030193
WBInteraction000030895
WBInteraction000030896
WBInteraction000030897
WBInteraction000030898
WBInteraction000030899
WBInteraction000030900
WBInteraction000030901
WBInteraction000030902
WBInteraction000030903
WBInteraction000030904
WBInteraction000134052
WBInteraction000134053
WBInteraction000134554
WBInteraction000136778
WBInteraction000140928
WBInteraction000144078
WBInteraction000147096
WBInteraction000147172
WBInteraction000149426
WBInteraction000183333
WBInteraction000189249
WBInteraction000204548
WBInteraction000217605
WBInteraction000217945
WBInteraction000222264
WBInteraction000226794
WBInteraction000247913
WBInteraction000251937
WBInteraction000253223
WBInteraction000269060
WBInteraction000273970
WBInteraction000306564
WBInteraction000322036
WBInteraction000327126
WBInteraction000332183
WBInteraction000358887
WBInteraction000364511
WBInteraction000381918
WBInteraction000384180
WBInteraction000384181
WBInteraction000384182
WBInteraction000384183
WBInteraction000384184
WBInteraction000398162
WBInteraction000427867
WBInteraction000431610
WBInteraction000444450
WBInteraction000459914
WBInteraction000461122
WBInteraction000507236
WBInteraction000507237
WBInteraction000507243
WBInteraction000507244
WBInteraction000507245
WBInteraction000507246
WBInteraction000507247
WBInteraction000508321
WBInteraction000508322
WBInteraction000508323
WBInteraction000508325
WBInteraction000508326
WBInteraction000513695
WBInteraction000513696
WBInteraction000513698
WBInteraction000513699
WBInteraction000513700
WBInteraction000513701
WBInteraction000513702
WBInteraction000513703
WBInteraction000513704
WBInteraction000513705
WBInteraction000513706
WBInteraction000513707
WBInteraction000513708
WBInteraction000513709
WBInteraction000513710
WBInteraction000513711
WBInteraction000513712
WBInteraction000513713
WBInteraction000513714
WBInteraction000513715
WBInteraction000513716
WBInteraction000513717
WBInteraction000513719
WBInteraction000513720
WBInteraction000513721
WBInteraction000513722
WBInteraction000513724
WBInteraction000513725
WBInteraction000513726
WBInteraction000513727
WBInteraction000516300
WBInteraction000516301
WBInteraction000516302
WBInteraction000516303
WBInteraction000516304
WBInteraction000516367
WBInteraction000516368
WBInteraction000516369
WBInteraction000516370
WBInteraction000516371
WBInteraction000516372
WBInteraction000516373
WBInteraction000516374
WBInteraction000516375
WBInteraction000516376
WBInteraction000516377
WBInteraction000516378
WBInteraction000516379
WBInteraction000516380
WBInteraction000516381
WBInteraction000521042
WBInteraction000521514
WBInteraction000534777
WBInteraction000534778
WBInteraction000539834
WBInteraction000547089
WBInteraction000547090
WBInteraction000550934
WBInteraction000569839
WBInteraction000569841
WBInteraction000569843
WBInteraction000580097
WBProcessWBbiopr:00000039
Map_infoMapIPosition3.85381Error0.000485
PositivePositive_cloneC04F12Inferred_automaticallyFrom sequence, transcript, pseudogene data
Mapping_dataMulti_point4781
Pseudo_map_position
Reference (18)
RemarkMap position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene