WormBase Tree Display for Gene: WBGene00002125

WBGene00002125 SMap: S_parent: Sequence: F22F4
  Identity: Version: 1
    Name: CGC_name: inx-3 Person_evidence: WBPerson247
      Sequence_name: F22F4.2
      Molecular_name: F22F4.2
        F22F4.2.1
        CE33055
      Other_name: opu-3
        CELE_F22F4.2 Accession_evidence: NDB BX284606
      Public_name: inx-3
    DB_info: Database: AceView gene XG615
        WormQTL gene WBGene00002125
        WormFlux gene WBGene00002125
        NDB locus_tag CELE_F22F4.2
        Panther gene CAEEL|WormBase=WBGene00002125|UniProtKB=Q19746
          family PTHR11893
        NCBI gene 180866
        RefSeq protein NM_076601.7
        SwissProt UniProtAcc Q19746
        UniProt_GCRP UniProtAcc Q19746
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:26 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: inx
    Allele (31)
    Legacy_information: [Barnes TM] opu for OPUS protein.
    Strain: WBStrain00035658
      WBStrain00007118
    RNASeq_FPKM (74)
    GO_annotation (20)
    Ortholog (46)
    Paralog (24)
    Structured_description: Automated_description: Enables actin filament binding activity and gap junction channel activity. Involved in embryonic morphogenesis and positive regulation of pharyngeal pumping. Located in cytoplasm and gap junction. Expressed in several structures, including arcade cell; cephalic sheath cell; neurons; pharyngeal cell; and rectum. Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: F22F4.2
    Corresponding_CDS_history: F22F4.2:wp92
    Corresponding_transcript: F22F4.2.1
    Other_sequence (47)
    Associated_feature (13)
  Experimental_info: RNAi_result: WBRNAi00027681 Inferred_automatically: RNAi_primary
      WBRNAi00092183 Inferred_automatically: RNAi_primary
      WBRNAi00062020 Inferred_automatically: RNAi_primary
      WBRNAi00027295 Inferred_automatically: RNAi_primary
      WBRNAi00025189 Inferred_automatically: RNAi_primary
      WBRNAi00066626 Inferred_automatically: RNAi_primary
      WBRNAi00013776 Inferred_automatically: RNAi_primary
      WBRNAi00066688 Inferred_automatically: RNAi_primary
      WBRNAi00045349 Inferred_automatically: RNAi_primary
    Expr_pattern (11)
    Drives_construct: WBCnstr00000925
      WBCnstr00010537
      WBCnstr00010849
      WBCnstr00013438
      WBCnstr00016939
      WBCnstr00036434
    Construct_product: WBCnstr00010849
      WBCnstr00036434
      WBCnstr00038753
    Antibody: WBAntibody00000617
    Microarray_results (21)
    Expression_cluster: WBPaper00024505:pharyngeal_enriched
      WBPaper00028788:MPK-1_Response_Weak
      WBPaper00031040:TGF-beta_adult_downregulated
      WBPaper00033065:cyc-1(RNAi)_downregulated
      WBPaper00033065:isp-1-1(qm150)_upregulated
      WBPaper00037682:sma-2_upregulated
      WBPaper00037849:sam-10(js94)_upregulated
      WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
      WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
      WBPaper00037950:hypodermis_L1-larva_expressed
      WBPaper00037950:hypodermis_L3-L4-larva_expressed
      WBPaper00037950:intestine_L1-larva_expressed
      WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
      WBPaper00038168:lin-15B(n744)_upregulated
      WBPaper00040209:B.thuringiensis_downregulated_MY15
      WBPaper00040209:B.thuringiensis_downregulated_MY18
      WBPaper00040209:B.thuringiensis_downregulated_N2
      WBPaper00042477:rsr-2(RNAi)_upregulated_TilingArray
      WBPaper00043945:MeHg_upregulated
      WBPaper00044260:1-methylnicotinamide_downregulated
      WBPaper00044260:nicotic-acid_downregulated
      WBPaper00044316:CH3HgCl_7.5uM_downregulated
      WBPaper00044578:reduced-humidity_downregulated_microarray
      WBPaper00044656:tatn-1(qd182)_downregulated
      WBPaper00044736:oscillating_dev_expression
      WBPaper00044786:emr-1(gk119)_downregulated
      WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_downregulated
      WBPaper00045257:bar-1(ga80)_upregulated
      WBPaper00045417:128Q-huntingtin_downreglated
      WBPaper00045420:fertilization_downregulated_transcript
      WBPaper00045420:fertilization_upregulated_protein
      WBPaper00045521:Oogenic
      WBPaper00045618:puf-8_downregulated
      WBPaper00045729:gld-2(RNAi)_downregulated
      WBPaper00045934:wrn-1(gk99)_upregulated
      WBPaper00046337:monosomal_N2_vs_daf-2_upregulated
      WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h
      WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h
      WBPaper00046509:htz-1(ok3099)_downregulated
      WBPaper00046509:lin-35(n745)_downregulated
      WBPaper00048988:neuron_expressed
      WBPaper00049377:MWCNT_downregulated
      WBPaper00049545:jmjd-3.1(+)_downregulated
      WBPaper00049905:Age_variant_expression
      WBPaper00049954:BPS_upregulated
      WBPaper00050080:rbr-2(tm3141)_downregulated
      WBPaper00050234:lin-28(RNAi)_upregulated
      WBPaper00050370:dpy-21(e428)_L3_upregulated
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
      WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C
      WBPaper00050522:mafr-1(tm6082)_downregulated
      WBPaper00050712:RC301_vs_DA650_4h-PA_upregulated
      WBPaper00050726:OsmoticStress_regulated_Food
      WBPaper00050726:OsmoticStress_regulated_NoFood
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050990:GABAergic-neuron_enriched
      WBPaper00050990:GABAergic-neuron_expressed
      WBPaper00051039:germline_enriched
      WBPaper00051265:F4_morc-1(tm6048)_upregulated
      WBPaper00051404:alg-1(gk214)_upregulated
      WBPaper00052884:emb-4(hc60)_downregulated
      WBPaper00052987:UV_upregulated_xpc-1;csb-1
      WBPaper00053184:sma-4(rax3)_downregulated
      WBPaper00053295:lin-22(ot269)_downregulated
      WBPaper00053321:embryo-to-L1_downregulated_WT_SMARTseq
      WBPaper00053321:lin-15B(RNAi)_downregulated_starved-L1_Truseq
      WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_fed-L1_Truseq
      WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_L1_SMARTseq
      WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_starved-L1_Truseq
      WBPaper00053321:PGCs_depleted_NuGen
      WBPaper00053388:dauer_regulated_Cluster1
      WBPaper00053402:cco-1(RNAi)_upregulated
      WBPaper00053599:female_vs_male_upregulated
      WBPaper00053599:mitosis_vs_meiosis_downregulated
      WBPaper00053599:oocyte_vs_mitosis_downregulated
      WBPaper00053606:N2_vs_elt-2(ca15);elt-7(tm840)_upregulated
      WBPaper00053606:N2_vs_elt-2(ca15)_upregulated
      WBPaper00053615:SMO-1_target
      WBPaper00053814:15C_downregulated_OP50
      WBPaper00053814:15C_downregulated_PY79
      WBPaper00054493:hpl-2(tm1489)_downregulated
      WBPaper00055013:hmg-3(bar24)_upregulated
      WBPaper00055354:Rapamycin-Rifampicin-Psora_downregulated
      WBPaper00055354:Rifampicin-Psora_downregulated
      WBPaper00055386:daf-2(e1370)_downregulated
      WBPaper00055386:eat-2(ad465)_downregulated
      WBPaper00055482:Tunicamycin_upregulated
      WBPaper00055626:pry-1(mu38)_downregulated
      WBPaper00055648:germline_expressed
      WBPaper00055648:nerve-ring_expressed
      WBPaper00055804:FBF-1-FBF-2-associated_oogenic-enriched
      WBPaper00055862:antimycin_damt-1(gk961032)_regulated
      WBPaper00055971:nhl-2(ok818)_20C_upregulated
      WBPaper00055971:nhl-2(ok818)_25C_upregulated
      WBPaper00056034:pals-22(jy3)_downregulated
      WBPaper00056139:soil-microbiota_upregulated
      WBPaper00056161:hermaphrodite_enriched_siRNA
      WBPaper00056167:Cry5B_upregulated
      WBPaper00056290:hsp-6(mg585)_upregulated
      WBPaper00056443:sek-1(km4)_upregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
      WBPaper00056855:his-72(uge40)_downregulated
      WBPaper00057006:DietaryRestriction_downregulated
      WBPaper00057041:spc-1(cas971)_upregulated
      WBPaper00057041:unc-70(cas983)_upregulated
      WBPaper00057288:Cold_downregulated_transcript
      WBPaper00057288:iff-1(RNAi)_downregulated_transcript
      WBPaper00059027:neuron-synapses_enriched
      WBPaper00059328:mrps-5(RNAi)_upregulated_mRNA
      WBPaper00059471:EGL-43_interacting
      WBPaper00059664:srbc-48(ac23)_downregulated
      WBPaper00059728:5ug_cholesterol_downregulated
      WBPaper00059728:20ug_cholesterol_downregulated
      WBPaper00059763:neuron_expressed
      WBPaper00060445:ikb-1(nr2027)_upregulated_L4
      WBPaper00060445:nfki-1(cer1)_upregulated_L4
      WBPaper00060459:bcat-1(RNAi)_downregulated
      WBPaper00060634:fhod-1(tm2363)_upregulated
      WBPaper00060661:sensory-neuron_depleted
      WBPaper00060683:hlh-11(ko1)_downregulated
      WBPaper00060764:swsn-1(os22ts)_downregulated
      WBPaper00060909:atfs-1(cmh15)_upregulated
      WBPaper00061007:HB101_downregulated
      WBPaper00061007:S.aquatilis_downregulated
      WBPaper00061274:hypergravity_15xg_upregulated
      WBPaper00061274:microgravity_upregulated
      WBPaper00061340:AVH_parent
      WBPaper00061340:Body_wall_muscle
      WBPaper00061340:Excretory_cell_parent
      WBPaper00061340:GLR
      WBPaper00061340:mc1
      WBPaper00061340:mc3
      WBPaper00061340:Neuroblast_AFD_RMD
      WBPaper00061340:Neuroblast_ASE_ASJ_AUA
      WBPaper00061340:Neuroblast_ASG_AWA
      WBPaper00061340:Neuroblast_AVG_RIR
      WBPaper00061340:Parents_of_PHsh_hyp8_hyp9
      WBPaper00061340:Parents_of_U_F_B_DVA
      WBPaper00061340:Parent_of_AMsh_URB
      WBPaper00061340:Parent_of_exc_duct_pore_DB_1_3
      WBPaper00061340:Parent_of_exc_gland_AVK
      WBPaper00061340:Parent_of_K_Kprime
      WBPaper00061340:Parent_of_PVP_and_rect_V
      WBPaper00061340:Parent_of_tail_spike_and_hyp10
      WBPaper00061340:Pharyngeal_intestinal_valve
      WBPaper00061340:pm8
      WBPaper00061340:RID_parent
      WBPaper00061424:Diet_MYb120_downregulated
      WBPaper00061424:Diet_MYb131_upregulated
      WBPaper00061527:ZK1053.4-C08F1.6
      WBPaper00061613:human-alpha-Synuclein(A53T)_upregulated
      WBPaper00061613:human-amyloid-beta_alpha-Synuclein(A53T)_upregulated
      WBPaper00061613:human-amyloid-beta_upregulated
      WBPaper00061753:csr-1(tor159)_downregulated_25C
      WBPaper00061753:csr-1(tor159)_upregulated_20C
      WBPaper00061818:ELKS-1_interacting
      WBPaper00062146:MOG-7-degron_2h_regulated
      WBPaper00062156:jmjd-5(zr1234)_updownregulated
      WBPaper00062159:hda-2(ok1479)_downregulated
      WBPaper00062325:muscle_depleted_coding-RNA
      WBPaper00062456:doxycycline_downregulated_CB4856_protein
      WBPaper00062456:doxycycline_downregulated_CB4856_transcript
      WBPaper00062456:doxycycline_downregulated_N2_transcript
      WBPaper00062520:qui-1(db104)_downregulated
      WBPaper00062585:hlh-26(ok1453)_downregulated_E.faecium
      WBPaper00062587:lsl-1(ljm1)_downregulated
      WBPaper00062587:lsl-1(tm4769)_downregulated
      WBPaper00062590:Aging_upregulated_body-wall-muscle
      WBPaper00062669:extracellular-vesicle_protein
      WBPaper00064005:starvation_downregulated_aptf-1(gk794)_mRNA
      WBPaper00064005:starvation_downregulated_N2_mRNA
      WBPaper00064071:NHR-49_interacting
      WBPaper00064201:SNA-3_interacting
      WBPaper00064229:B.thuringiensis-Cry5Ba_downregulated
      WBPaper00064315:mes-3(bn199)_upregulated_EGCs
      WBPaper00064315:mes-4(bn73)_upregulated_EGCs
      WBPaper00064403:Heat-killed-E.Coli_upregulated
      WBPaper00064505:tamoxifen_upregulated
      WBPaper00064716:paraquat_upregulated
      WBPaper00064769:him-17(me24)_downregulated
      WBPaper00064871:hypoxia_downregulated_F1
      WBPaper00064933:bcf-1(ylf1)_upregulated_transcript
      WBPaper00065096:25C_vs_20C_upregulated
      WBPaper00065096:Day10_vs_Day1_upregulated
      WBPaper00065096:npr-8(ok1439)_downregulated_Day1_25C
      WBPaper00065096:npr-8(ok1439)_downregulated_Day10_20C
      WBPaper00065096:npr-8(ok1439)_downregulated_Day10_25C
      WBPaper00065096:npr-8(ok1439)_upregulated_Day1_20C
      WBPaper00065158:25C_vs_15C_upregulated_AFD
      WBPaper00065158:25C_vs_15C_upregulated_WholeAnimal
      WBPaper00065158:AFD_depleted
      WBPaper00065373:sek-1(km4)_upregulated_cisplatin
      WBPaper00065373:sek-1(km4)_upregulated_Ref
      WBPaper00065835:Day11_vs_Day1_upregulated
      WBPaper00065841:1_0
      WBPaper00065841:1_2
      WBPaper00065841:7_4
      WBPaper00065841:24_1
      WBPaper00065841:25_1
      WBPaper00065841:26_2
      WBPaper00065841:31_0
      WBPaper00065841:78_0
      WBPaper00065926:pgph-2(overepxreesion)_upregulated_glucose
      WBPaper00065975:P-body_vs_oocyte_enriched
      WBPaper00065975:P-body_vs_WholeAnimal_enriched
      WBPaper00065984:pals-17(syb3980)_upregulated
      WBPaper00065993:glp-1(e2141)_downregulated
      WBPaper00066093:E.coli-purE_downregulated
      WBPaper00066110:Cisplatin_downregulated_diploid
      WBPaper00066110:Doxorubicin_downregulated_diploid
      WBPaper00066110:tetraploid_vs_diploid_downregulated
      WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14
      WBPaper00066204:CdCl2_downregulated_mRNA
      cgc4386_cluster_6_2
      cgc4489_group_9
      WBPaper00005475:Aging-regulated
      WBPaper00024671:AFD_AWB_vs_unsorted_upregulated
      WBPaper00025032:cluster_2
      WBPaper00025032:cluster_7
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00026929:Resveratrol_regulated_daf-16
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00027111:rrf-2(ok210)_upregulated
      WBPaper00029437:dcr-1_upregulated
      WBPaper00030985:Enterococcus_faecalis_upregulated
      WBPaper00030985:Erwinia_carotovora_upregulated
      WBPaper00031003:0hr_muscle_depleted
      WBPaper00031003:24hr_muscle_depleted
      WBPaper00031003:total_muscle_depleted
      WBPaper00032062:age_regulated_genes
      WBPaper00032165:differentially_expressed_with_age_medoid_1
      WBPaper00034739:N2lessDR1350
      WBPaper00035873:dpy-9_regulated
      WBPaper00035873:dpy-10_regulated
      WBPaper00035905:FBF-1_Associated
      WBPaper00036130:mir-243_down_regulated
      WBPaper00036286:Pattern_D
      WBPaper00036383:ash-2_Day8_regulated
      WBPaper00038172:crh-1null_up_regulated
      WBPaper00039866:ClassComp_daf-19_upregulated
      WBPaper00039866:SAM_daf-19_upregulated
      WBPaper00040210:Chlorpyrifos_24C_regulated
      WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2
      WBPaper00040963:Q100_down
      WBPaper00040963:Q200_down
      WBPaper00041002:HF_3d_0.2mM_Down
      WBPaper00041002:HF_3d_2.0mM_Down
      WBPaper00041606:CE_S.marcescens_regulated
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00041960:daf-16_fasting_upregulated
      WBPaper00041960:kgb-1_fasting_upregulated
      WBPaper00041960:N2_fasting_upregulated
      WBPaper00041960:N2_fasting_upregulated_9hto12h
      WBPaper00041960:N2_fasting_upregulated_anytime
      WBPaper00042258:DA1877_downregulated_GravidAdult
      WBPaper00045263:0.1mM-paraquat_upregulated
      WBPaper00045263:isp-1(qm150)_upregulated
      WBPaper00045263:nuo-6(qm200)_upregulated
      WBPaper00045263:ProLongevity-mtROS_upregulated
      WBPaper00046083:pmk-1(km25)_OP50_upregulated
      WBPaper00048567:dnj-14_downregulated
      WBPaper00048989:N2_rapamycin_downregulated
      WBPaper00050538:Fasting_upregulated
      WBPaper00051387:Triclosan_downregulated
      WBPaper00053550:daf-19(m86)_upregulated_3-fold-embryo
      WBPaper00056330:mrps-5(RNAi)_downregulated
      WBPaper00057098:SiO2-nanoparticles_upregulated
      [cgc5767]:cluster_2
      [cgc5767]:expression_class_E
      [cgc5767]:expression_class_E_pi(23_min)
      [cgc5767]:expression_class_M
      [cgc5767]:expression_class_ME
      [cgc6390]:Cluster_E
      [cgc6390]:intrinsic
    Interaction (150)
  Map_info: Map: X Position: -3.91398 Error: 0.016666
    Positive: Positive_clone: F22F4 Person_evidence: WBPerson43
          Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4443
        4456
    Pseudo_map_position
  Reference (15)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene