WormBase Tree Display for Gene: WBGene00002228
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| WBGene00002228 | SMap | S_parent | Sequence | C06G3 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | klp-18 | Person_evidence | WBPerson589 | |||||
| Sequence_name | C06G3.2 | ||||||||
| Molecular_name | C06G3.2 | ||||||||
| C06G3.2.1 | |||||||||
| CE07978 | |||||||||
| Other_name | CELE_C06G3.2 | Accession_evidence | NDB | BX284604 | |||||
| Public_name | klp-18 | ||||||||
| DB_info | Database | AceView | gene | 4H807 | |||||
| WormQTL | gene | WBGene00002228 | |||||||
| WormFlux | gene | WBGene00002228 | |||||||
| NDB | locus_tag | CELE_C06G3.2 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00002228|UniProtKB=G5EBX0 | |||||||
| family | PTHR24115 | ||||||||
| NCBI | gene | 177474 | |||||||
| RefSeq | protein | NM_068692.5 | |||||||
| TREEFAM | TREEFAM_ID | TF320478 | |||||||
| TrEMBL | UniProtAcc | G5EBX0 | |||||||
| UniProt_GCRP | UniProtAcc | G5EBX0 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:27 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | klp | ||||||||
| Allele (45) | |||||||||
| Strain | WBStrain00036968 | ||||||||
| WBStrain00007392 | |||||||||
| WBStrain00049767 | |||||||||
| WBStrain00049537 | |||||||||
| WBStrain00049796 | |||||||||
| WBStrain00049736 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (19) | |||||||||
| Ortholog (42) | |||||||||
| Paralog (20) | |||||||||
| Structured_description | Concise_description | klp-18 encodes a kinesin motor protein whose motor domain is most similar to that of the Xenopus and human klp2 proteins; loss of klp-18 activity via RNAi indicates that KLP-18 is required for the assembly of a disordered array of acentrosomal (female meiotic) microtubules into an organized, functional, bipolar spindle; in addition, KLP-18 may also play a role in cortex dynamics during post-meiotic development; antibody staining indicates that during meiosis and mitosis (early embryonic) KLP-18 localizes to: 1) spindles, and especially spindle poles, during prometaphase, metaphase, and early anaphase, and 2) the interzone during late anaphase and telophase; in early embryos, KLP-18 is also seen around the nucleus and cell cortex at sites of cell-cell contact; KLP-18 expression in later embryos and larvae is confined to the germ line which, in adults, stains brightly in both distal and proximal regions. | Paper_evidence | WBPaper00006197 | |||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 15 Nov 2005 00:00:00 | ||||||||
| Automated_description | Predicted to enable ATP hydrolysis activity; microtubule binding activity; and microtubule motor activity. Involved in meiotic spindle assembly. Located in cell cortex; microtubule; and spindle pole. Expressed in Z2; Z3; and germ line. Is an ortholog of human KIF15 (kinesin family member 15). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | C06G3.2 | |||||||
| Corresponding_transcript | C06G3.2.1 | ||||||||
| Other_sequence | XI02457 | ||||||||
| OOC00018_1 | |||||||||
| Tcol_isotig22220 | |||||||||
| CJC11439_1 | |||||||||
| CJC03116_1 | |||||||||
| Associated_feature | WBsf977135 | ||||||||
| WBsf977136 | |||||||||
| WBsf977137 | |||||||||
| WBsf977138 | |||||||||
| WBsf996872 | |||||||||
| WBsf1017643 | |||||||||
| WBsf228493 | |||||||||
| WBsf228494 | |||||||||
| Experimental_info | RNAi_result (23) | ||||||||
| Expr_pattern | Expr2631 | ||||||||
| Expr2632 | |||||||||
| Expr1010889 | |||||||||
| Expr1031305 | |||||||||
| Expr1144008 | |||||||||
| Expr2012961 | |||||||||
| Expr2031193 | |||||||||
| Drives_construct | WBCnstr00036371 | ||||||||
| Construct_product | WBCnstr00036371 | ||||||||
| Antibody | WBAntibody00000693 | ||||||||
| WBAntibody00000694 | |||||||||
| Microarray_results (31) | |||||||||
| Expression_cluster (175) | |||||||||
| Interaction (27) | |||||||||
| Map_info | Map | IV | Position | 3.2795 | Error | 0.000501 | |||
| Positive | Positive_clone | C06G3 | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Pseudo_map_position | |||||||||
| Reference (25) | |||||||||
| Remark | Sequence connection from [Siddiqui SS], [krb 020711] | ||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
