WormBase Tree Display for Gene: WBGene00002235
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| WBGene00002235 | Evidence | CGC_data_submission | |||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | Y54G9A | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | kqt-3 | Person_evidence | WBPerson655 | |||||
| Sequence_name | Y54G9A.3 | ||||||||
| Molecular_name | Y54G9A.3a | ||||||||
| Y54G9A.3a.1 | |||||||||
| CE32760 | |||||||||
| Y54G9A.3b | |||||||||
| CE43414 | |||||||||
| Y54G9A.3c | |||||||||
| CE43403 | |||||||||
| Y54G9A.3a.2 | |||||||||
| Y54G9A.3b.1 | |||||||||
| Y54G9A.3c.1 | |||||||||
| Other_name | CELE_Y54G9A.3 | Accession_evidence | NDB | BX284602 | |||||
| Public_name | kqt-3 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:27 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | kqt | ||||||||
| Allele (544) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (20) | |||||||||
| Ortholog (39) | |||||||||
| Paralog (13) | |||||||||
| Structured_description | Concise_description | kqt-3 encodes one of three C. elegans KCNQ-like potassium channel subunits and, with respect to humans, is most similar to the KCNQ1 channel protein which when mutated leads to inherited long QT syndrome (OMIM:607542); although loss of KQT-3 activity via large-scale RNAi screens results in no obvious abnormalities, KQT-3 likely functions to regulate cellular excitability as expression of KQT-3 in Xenopus oocytes can produce K+ channel currents that functionally resemble vertebrate M-currents; activity of these KQT-3 channels can be suppressed by coexpression with the human M1 muscarinic receptor and treatment with diacylglycerol analogs, although KQT-3 is less sensitive to each of these treatments than KQT-1; a KQT-3::GFP fusion protein is expressed in the anterior- and posterior-most intestinal cells, the anterior and posterior mechanosensory neurons ALM and PLM, amphid and phasmid neurons, and in some additional head neurons. | Paper_evidence | WBPaper00004103 | |||||
| WBPaper00025059 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 10 May 2007 00:00:00 | ||||||||
| Automated_description | Enables potassium channel activity. Involved in G protein-coupled acetylcholine receptor signaling pathway and potassium ion transport. Predicted to be located in plasma membrane and synapse. Predicted to be part of voltage-gated potassium channel complex. Expressed in head neurons; intestine; and sensory neurons. Used to study Jervell-Lange Nielsen syndrome. Human ortholog(s) of this gene implicated in heart conduction disease (multiple); long QT syndrome (multiple); and seminoma. Is an ortholog of human KCNQ1 (potassium voltage-gated channel subfamily Q member 1). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:2842 | Homo sapiens | Paper_evidence | WBPaper00025059 | ||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 03 Oct 2018 00:00:00 | ||||||||
| DOID:2843 | Homo sapiens | Paper_evidence | WBPaper00025059 | ||||||
| Accession_evidence | OMIM | 192500 | |||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 04 Apr 2013 00:00:00 | ||||||||
| Potential_model | DOID:0050793 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6294) | |||||
| DOID:2842 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6294) | ||||||
| DOID:0050650 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6294) | ||||||
| DOID:9352 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6294) | ||||||
| DOID:2843 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6294) | ||||||
| DOID:0060224 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6294) | ||||||
| DOID:0110644 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6294) | ||||||
| DOID:4440 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6294) | ||||||
| Disease_relevance | The kqt genes in elegans (kqt-1, kqt-2, kqt-3) are most similar to the human KCNQ multi-gene family encoding potassium channels; C. elegans kqt-1 defines a subfamily of potassium channel genes along with the human KCNQ2-5 and kqt-3 is most similar to KCNQ1; mutations in human KCNQ genes have been associated with genetic disorders of cardiac arrhythmia and deafness; mutations in KCNQ1 are associated with Atrial fibrillation (familial 3), Jervell and Lange-Nielen syndrome, Long-QT syndrome-1, and Short QT syndrome-2; studies in elegans show that the suppression of KCNQ/KQTchannels by diacylglycerol (DAG) is dependent on the carboxyl terminal domains of the channel subunits and activated protein kinase C. | Homo sapiens | Paper_evidence | WBPaper00025059 | |||||
| Accession_evidence | OMIM | 607554 | |||||||
| 220400 | |||||||||
| 192500 | |||||||||
| 609621 | |||||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 07 May 2012 00:00:00 | ||||||||
| Models_disease_in_annotation | WBDOannot00000064 | ||||||||
| WBDOannot00000302 | |||||||||
| Molecular_info | Corresponding_CDS | Y54G9A.3a | |||||||
| Y54G9A.3b | |||||||||
| Y54G9A.3c | |||||||||
| Corresponding_CDS_history | Y54G9A.3:wp91 | ||||||||
| Corresponding_transcript | Y54G9A.3a.1 | ||||||||
| Y54G9A.3a.2 | |||||||||
| Y54G9A.3b.1 | |||||||||
| Y54G9A.3c.1 | |||||||||
| Other_sequence (57) | |||||||||
| Associated_feature (13) | |||||||||
| Experimental_info | RNAi_result | WBRNAi00057477 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00020995 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00088720 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00088613 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00020994 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00037500 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr3236 | ||||||||
| Expr1017115 | |||||||||
| Expr1031312 | |||||||||
| Expr1160921 | |||||||||
| Expr2012978 | |||||||||
| Expr2031210 | |||||||||
| Drives_construct | WBCnstr00011242 | ||||||||
| Construct_product | WBCnstr00011242 | ||||||||
| WBCnstr00040826 | |||||||||
| Microarray_results (23) | |||||||||
| Expression_cluster (97) | |||||||||
| Interaction (11) | |||||||||
| Map_info | Map | II | Position | 19.5801 | Error | 0.102694 | |||
| Positive | Positive_clone | Y54G9A | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 4469 | |||||||
| Pseudo_map_position | |||||||||
| Reference (19) | |||||||||
| Picture | WBPicture0000013535 | ||||||||
| Remark | Sequence connection from [Wei A] | ||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
