| WBGene00002239 | SMap | S_parent | Sequence | F13B9 |
|---|
| Identity | Version | 1 |
| | Name | CGC_name | ksr-1 | Person_evidence | WBPerson237 |
| | | Sequence_name | F13B9.5 |
| | | Molecular_name | F13B9.5 |
| | | | F13B9.5.1 |
| | | | CE25854 |
| | | Other_name | sur-3 |
| | | | sar-2 |
| | | | CELE_F13B9.5 | Accession_evidence | NDB | BX284606 |
| | | Public_name | ksr-1 |
| | DB_info | Database (13) |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:27 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | ksr |
| | Allele (175) |
| | Legacy_information | [Kornfeld K] ksr for kinase suppressor of ras. ksr-1 loss-of-function mutations suppress the multivulva phenotype caused by let-60(n1046gf), cause a very low penetrance defect in vulval lineages, and cause about 10% larval lethality with a characteristic rod-like morphology. |
| | | [C.elegansII] pka sur-3, sar-2. Mutations suppress ras mutation,let-60(n1046gf). No phenotype alone in VPC; some larval lethality, Egl and Mig phenotypes. [MT; MH] |
| | Strain | WBStrain00026498 |
| | | WBStrain00026503 |
| | | WBStrain00027335 |
| | | WBStrain00027336 |
| | | WBStrain00027337 |
| | | WBStrain00031627 |
| | RNASeq_FPKM (74) |
| | GO_annotation (25) |
| | Ortholog (40) |
| | Paralog (11) |
| | Structured_description | Concise_description | ksr-1 encodes one of two C. elegans Kinase Suppressor of Ras paralogs; during development, ksr-1 functions singly to control sex myoblast migration and redundantly with ksr-2 to control development of the vulva, excretory system, and male spicules; as ksr-2; ksr-1 doubly mutant animals have severely reduced or absent MPK-1/ERK diphosphorylation levels in somatic tissue, KSR-2 and KSR-1 likely function to positively regulate signaling through the LET-60/Ras pathway; genetic analyses have identified a number of ekl (enhancer of ksr-1 lethality ) mutations that, in combination with a ksr-1 null mutation, result in defects in excretory duct cell fate specification accompanied by larval lethality; the ekl mutations identified gene products that are maternally required for duct cell fate specification and encode proteins likely to be involved in transcriptional and post-transcriptional gene regulation. | Paper_evidence | WBPaper00002350 |
| | | | | | WBPaper00002351 |
| | | | | | WBPaper00005155 |
| | | | | | WBPaper00031487 |
| | | | | Curator_confirmed | WBPerson1843 |
| | | | | Date_last_updated | 12 May 2009 00:00:00 |
| | | Automated_description | Enables mitogen-activated protein kinase kinase binding activity and protein kinase activity. Involved in several processes, including defense response to Gram-positive bacterium; myoblast migration; and positive regulation of vulval development. Predicted to be located in cytoplasm. Human ortholog(s) of this gene implicated in breast adenocarcinoma. Is an ortholog of human KSR1 (kinase suppressor of ras 1). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Disease_info | Potential_model | DOID:3458 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6465) |
| | | DOID:1612 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6465) |
| Molecular_info | Corresponding_CDS | F13B9.5 |
| | Corresponding_transcript | F13B9.5.1 |
| | Other_sequence (19) |
| | Associated_feature | WBsf663032 |
| | | WBsf1006098 |
| | | WBsf1006099 |
| | | WBsf1006100 |
| | | WBsf1023389 |
| | | WBsf1023390 |
| | | WBsf236034 |
| Experimental_info | RNAi_result (11) |
| | Expr_pattern | Expr1011978 |
| | | Expr1031314 |
| | | Expr1148436 |
| | | Expr2012981 |
| | | Expr2031213 |
| | Drives_construct | WBCnstr00036367 |
| | Construct_product | WBCnstr00036367 |
| | Microarray_results (25) |
| | Expression_cluster | WBPaper00032976:dosage_compensated_genes |
| | | WBPaper00033065:cyc-1(RNAi)_upregulated |
| | | WBPaper00036375:enriched_in_PVD_OLL |
| | | WBPaper00037950:A-class-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:all-neurons_L1-larva_expressed |
| | | WBPaper00037950:AVA-neuron_L1-larva_expressed |
| | | WBPaper00037950:BAG-neuron_blastula-embryo_expressed |
| | | WBPaper00037950:dopaminergic-neurons_L1-larva_expressed |
| | | WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed |
| | | WBPaper00037950:excretory-cell_L2-larva_expressed |
| | | WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:hypodermis_L3-L4-larva_expressed |
| | | WBPaper00037950:intestine_L2-larva_expressed |
| | | WBPaper00038438:S.marcescens_24hr_downregulated_TilingArray |
| | | WBPaper00040221:DAF-12_target_ALF4 |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00045521:Gender_Neutral |
| | | WBPaper00045974:NSM_enriched_totalRNA_RNAseq |
| | | WBPaper00046805:csr-1(RNAi)_downregulated_Set1 |
| | | WBPaper00048923:Aging_regulated |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049545:jmjd-3.1(+)_upregulated |
| | | WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated |
| | | WBPaper00050344:AFD-neuron_enriched |
| | | WBPaper00050488:20C_vs_25C_regulated_mir-34(gk437)_adult |
| | | WBPaper00050488:20C_vs_25C_regulated_mir-34(OverExpression)_adult |
| | | WBPaper00050488:20C_vs_25C_regulated_N2_adult |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C |
| | | WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult |
| | | WBPaper00050990:NMDA-neuron_enriched |
| | | WBPaper00050990:NMDA-neuron_expressed |
| | | WBPaper00051404:alg-1(gk214)_upregulated |
| | | WBPaper00051404:alg-2(ok304)_upregulated |
| | | WBPaper00052884:emb-4(hc60)_upregulated |
| | | WBPaper00053302:stavudine_24h_regulated |
| | | WBPaper00053321:PGCs_depleted_NuGen |
| | | WBPaper00053599:female_vs_male_upregulated |
| | | WBPaper00053599:oocyte_vs_mitosis_downregulated |
| | | WBPaper00053810:nuo-6(qm200)_upregulated |
| | | WBPaper00053814:25C_downregulated_OP50 |
| | | WBPaper00055334:DLC-1_interacting |
| | | WBPaper00055482:Tunicamycin_upregulated |
| | | WBPaper00055565:AVK_enriched |
| | | WBPaper00056443:sek-1(km4)_upregulated |
| | | WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated |
| | | WBPaper00056826:hmc_biased |
| | | WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C |
| | | WBPaper00058948:PA14_downregulated |
| | | WBPaper00059328:mrps-5(RNAi)_upregulated_mRNA |
| | | WBPaper00059471:EGL-43_interacting |
| | | WBPaper00059763:neuron_expressed |
| | | WBPaper00060014:set-2(zr2012)_downregulated |
| | | WBPaper00060661:sensory-neuron_enriched |
| | | WBPaper00060811:L1_vs_adult_upregulated_neural |
| | | WBPaper00061340:ABarpaaa_lineage |
| | | WBPaper00061340:AVH_parent |
| | | WBPaper00061340:Parent_of_hyp1V_and_ant_arc_V |
| | | WBPaper00061340:Parent_of_MI_pm1DR |
| | | WBPaper00061527:ldb-1_2877-scd-1_3086 |
| | | WBPaper00061651:ASG_enriched |
| | | WBPaper00062103:neuron_enriched |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20) |
| | | WBPaper00065258:anchor-cell_enriched |
| | | WBPaper00065841:55_0 |
| | | WBPaper00065995:M.humicola-extract_upregulated_old-1(ok1273) |
| | | WBPaper00066062:xrep-4(lax137)_upregulated |
| | | cgc4489_group_19 |
| | | WBPaper00024671:AFD_AWB_vs_unsorted_upregulated |
| | | WBPaper00025141:unc-4::GFP_Enriched_Genes |
| | | WBPaper00026929:sir-2.1_overexpression_regulated |
| | | WBPaper00029437:dcr-1_upregulated |
| | | WBPaper00030839:Embryo_A_Class |
| | | WBPaper00030839:Embryo_Pan_Neuronal |
| | | WBPaper00030839:Larval_Pan_Neuronal |
| | | WBPaper00031252:AIN-2_IP_enriched |
| | | WBPaper00031532:Larva_Pan_Neuronal_Enriched |
| | | WBPaper00035084:L1_enriched_AIN-2_IP |
| | | WBPaper00035084:L4_enriched_AIN-2_IP |
| | | WBPaper00035588:alg-1(-)_upregulated |
| | | WBPaper00036286:Pattern_D |
| | | WBPaper00037695:WC_5-day |
| | | WBPaper00041606:CE_X.nematophila_regulated |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_48h |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_51h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h |
| | | WBPaper00042331:a-SWCNTs_downregulated |
| | | WBPaper00045960:L4-lethargus_upregulated |
| | | WBPaper00048989:N2_rapamycin_downregulated |
| | | [cgc5767]:cluster_60 |
| | | [cgc5767]:expression_class_E |
| | | [cgc5767]:expression_class_E_pi(66_min) |
| | | [cgc5767]:expression_class_M |
| | | [cgc5767]:expression_class_ME |
| | Interaction (99) |
| | WBProcess | WBbiopr:00000071 |
| Map_info | Map | X | Position | -0.200671 | Error | 0.016778 |
| | Well_ordered |
| | Positive | Positive_clone | C33E9 | Person_evidence | WBPerson341 |
| | | | F13B9 | Person_evidence | WBPerson341 |
| | | | | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Mapping_data | Multi_point | 3616 |
| | | | 4468 |
| Reference (102) |
| Method | Gene |
