WormBase Tree Display for Gene: WBGene00002974
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| WBGene00002974 | SMap | S_parent | Sequence | F58D2 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | lev-1 | Person_evidence | WBPerson368 | |||||
| Sequence_name | F09E8.7 | ||||||||
| Molecular_name | F09E8.7a | ||||||||
| F09E8.7a.1 | |||||||||
| CE24888 | |||||||||
| F09E8.7b | |||||||||
| CE43918 | |||||||||
| F09E8.7b.1 | |||||||||
| Other_name | acr-1 | ||||||||
| tmr-1 | |||||||||
| CELE_F09E8.7 | Accession_evidence | NDB | BX284604 | ||||||
| Public_name | lev-1 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:30 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | lev | ||||||||
| Reference_allele | WBVar00143038 | ||||||||
| Allele (119) | |||||||||
| Legacy_information | e211 (pka tmr-1) : almost normal movement in absence of drug uncoordinated but not hypercontracted in 1 mM levamisole. ES2. ME3. NA > 10 (x22 etc.). Also two rare semidominant alleles with uncoordinated phenotype x21 : (uncoordinated Egl-c ME3) x63. | ||||||||
| See also e211, e289 | |||||||||
| [C.elegansII] e211 : (pka tmr-1) almost normal movement in absence of drug uncoordinated but not hypercontracted in 1 mM levamisole. ES2. ME3. OA>10: x22, e289, x577 etc. Also two rare semidominant alleles with uncoordinated phenotype, x21 (uncoordinated Egl-c, ME3), x63. Cloned: corresponds to acr-1, encoding subunit of nicotinic acetylcholine receptor. [Lewis et al. 1980, 1987; ZZ; MQ] | |||||||||
| Strain | WBStrain00003893 | ||||||||
| WBStrain00030691 | |||||||||
| WBStrain00033031 | |||||||||
| WBStrain00040924 | |||||||||
| WBStrain00000741 | |||||||||
| WBStrain00004129 | |||||||||
| WBStrain00004573 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (37) | |||||||||
| Ortholog (46) | |||||||||
| Paralog (100) | |||||||||
| Structured_description | Concise_description | lev-1 encodes a non-alpha subunit of nicotinic acetylcholine receptor (nAChR) which, when mutated, confers resistance to levamisole; LEV-1 is required for completely normal locomotion, regulation of egg-laying behavior, and forms a cation channel when coexpressed with UNC-38 or UNC-63 and UNC-29; LEV-1 falls into the 'UNC-29' class of nAChR subunits, which includes UNC-29, ACR-2, and ACR-3; a LEV-1::GFP fusion protein is expressed in all body wall muscle cells and a subset of ventral cord motor neurons. | Paper_evidence | WBPaper00000031 | |||||
| WBPaper00004660 | |||||||||
| WBPaper00005223 | |||||||||
| WBPaper00024530 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 20 Jun 2008 00:00:00 | ||||||||
| Automated_description | Enables acetylcholine receptor activity and acetylcholine-gated monoatomic cation-selective channel activity. Involved in regulation of egg-laying behavior; regulation of locomotion; and transmembrane transport. Located in neuron projection; neuronal cell body; and postsynaptic membrane. Expressed in body wall musculature; dorsal nerve cord; nerve ring; ventral cord neurons; and ventral nerve cord. Human ortholog(s) of this gene implicated in several diseases, including congenital myasthenic syndrome (multiple); lung disease (multiple); and nicotine dependence. Is an ortholog of human CHRNA1 (cholinergic receptor nicotinic alpha 1 subunit); CHRNA3 (cholinergic receptor nicotinic alpha 3 subunit); and CHRNA6 (cholinergic receptor nicotinic alpha 6 subunit). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:3905 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1957) | ||||
| DOID:5409 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1957) | ||||||
| DOID:3908 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1957) | ||||||
| DOID:3083 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1957) | ||||||
| DOID:10534 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1957) | ||||||
| DOID:0110663 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1955) | ||||||
| DOID:1324 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1957) | ||||||
| DOID:3910 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1957) | ||||||
| DOID:0050742 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1957) | ||||||
| DOID:0110662 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1955) | ||||||
| Molecular_info | Corresponding_CDS | F09E8.7a | |||||||
| F09E8.7b | |||||||||
| Corresponding_transcript | F09E8.7a.1 | ||||||||
| F09E8.7b.1 | |||||||||
| Other_sequence (14) | |||||||||
| Associated_feature | WBsf652327 | ||||||||
| WBsf668451 | |||||||||
| WBsf668452 | |||||||||
| WBsf668453 | |||||||||
| WBsf668454 | |||||||||
| WBsf998352 | |||||||||
| WBsf998353 | |||||||||
| WBsf1018500 | |||||||||
| WBsf231093 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00102763 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00012987 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00001574 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00066400 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00044139 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00066521 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr3395 | ||||||||
| Expr3708 | |||||||||
| Expr3709 | |||||||||
| Expr4346 | |||||||||
| Expr1027358 | |||||||||
| Expr1031374 | |||||||||
| Expr1148107 | |||||||||
| Expr2013085 | |||||||||
| Expr2031317 | |||||||||
| Drives_construct (12) | |||||||||
| Construct_product (14) | |||||||||
| Microarray_results (19) | |||||||||
| Expression_cluster (125) | |||||||||
| Interaction (25) | |||||||||
| Map_info | Map | IV | Position | 8.43149 | Error | 0.004865 | |||
| Well_ordered | |||||||||
| Positive | Inside_rearr | nDf27 | |||||||
| nDf28 | |||||||||
| sDf21 | |||||||||
| Positive_clone | F09E8 | Inferred_automatically | From sequence, transcript, pseudogene data | ||||||
| JF#WA10 | |||||||||
| Mapping_data | 2_point | 228 | |||||||
| 229 | |||||||||
| 347 | |||||||||
| 2726 | |||||||||
| 4660 | |||||||||
| 4661 | |||||||||
| 4666 | |||||||||
| Multi_point (19) | |||||||||
| Pos_neg_data (11) | |||||||||
| Reference (112) | |||||||||
| Method | Gene |
