WormBase Tree Display for Gene: WBGene00002993

WBGene00002993 SMap: S_parent: Sequence: F59G1
  Identity: Version: 1
    Name: CGC_name: lin-4 Person_evidence: WBPerson261
      Sequence_name: F59G1.6
      Molecular_name: F59G1.6
        F59G1.6a
        F59G1.6b
      Other_name: CELE_F59G1.6 Accession_evidence: NDB BX284602
      Public_name: lin-4
    DB_info: Database: SignaLink mirna cel-lin-4
        NDB locus_tag CELE_F59G1.6
        NCBI gene 266860
        RefSeq protein NR_000799.2
        RNAcentral URSid URS00001E2999
            URS0000278C03
            URS0000779DBB
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:30 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001265
    Gene_class: lin
    Reference_allele: WBVar00143592
    Allele (12)
    Legacy_information: e912pdi : heterochronic retarded adult hermaphrodites long abnormal movement vulvaless lack adult cuticle ES3 (adult) ES1 (larvae); HME0 (20x)/HME1 (15x) adult males lack copulatory structures ME0. NA1 (rare mutation).
      See also e912, n408, n409, n410
      [C.elegansII] e912pdi : heterochronic, retarded adult hermaphrodites long abnormal movement vulvaless lack adult cuticle ES3 (adult) ES1 (larvae); HME0 (20C)/HME1 (15C) adult males lack copulatory structures ME0. OA1: ma161 (resembles e912). Cloned: encodes two small RNAs with nocoding potential. [Lee et al. 1993; Wightman et al. 1993; GR; VT]
    Strain: WBStrain00026764
      WBStrain00026863
      WBStrain00027055
      WBStrain00027229
      WBStrain00027586
      WBStrain00040213
      WBStrain00004403
      WBStrain00006311
      WBStrain00051497
      WBStrain00051632
    RNASeq_FPKM (74)
    GO_annotation (16)
    Structured_description: Concise_description: lin-4 encodes a small non-coding temporal RNA (stRNA); lin-4 activity is required for regulating the timing of fate specification in neuronal and hypodermal lineages during postembryonic development; in the hypodermis, lin-4 represses translation of the lin-14 and lin-28 mRNAs, and in the ventral nerve cord, lin-4 regulates the expression of hbl-1 mRNA; in vitro, lin-4 binds the lin-14 mRNA 3' UTR to form an RNA duplex; lin-4 expression is temporally regulated, beginning at the end of the L1 larval stage and increasing to highest levels in adult animals; lin-4 is conserved in mammals and Drosophila, where it is known as miR-125. Paper_evidence: WBPaper00000496
            WBPaper00002609
            WBPaper00002728
            WBPaper00003583
            WBPaper00005159
            WBPaper00005825
            WBPaper00005909
          Curator_confirmed: WBPerson1843
          Date_last_updated: 18 Aug 2008 00:00:00
      Automated_description: Enables mRNA 3'-UTR binding activity. Involved in several processes, including egg-laying behavior; mating; and negative regulation of gene expression. Part of polysome. Expressed in several structures, including P5.p hermaphrodite; P7.p hermaphrodite; gonad; neurons; and ventral nerve cord. Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_transcript: F59G1.6
      F59G1.6a
      F59G1.6b
    Associated_feature: WBsf034324
      WBsf977968 Paper_evidence: WBPaper00044681
      WBsf979102
    Gene_product_binds: WBsf019183
      WBsf019184
      WBsf132693
  Experimental_info: Expr_pattern (14)
    Drives_construct: WBCnstr00000927
      WBCnstr00000928
      WBCnstr00004691
      WBCnstr00005149
      WBCnstr00005518
      WBCnstr00007615
      WBCnstr00015029
      WBCnstr00016040
      WBCnstr00019505
      WBCnstr00020503
    Construct_product: WBCnstr00000927
      WBCnstr00000928
      WBCnstr00007618
      WBCnstr00007620
      WBCnstr00007623
      WBCnstr00016930
    Regulate_expr_cluster: WBPaper00026952:class_A
      WBPaper00026952:class_B
      WBPaper00026952:class_C
      WBPaper00026952:class_D
      WBPaper00026952:class_E
      WBPaper00026952:class_F
      WBPaper00026952:class_G
      WBPaper00026952:class_H
    Expression_cluster (16)
    Interaction: WBInteraction000000072
      WBInteraction000000338
      WBInteraction000000656
      WBInteraction000000657
      WBInteraction000000660
      WBInteraction000000663
      WBInteraction000001130
      WBInteraction000001393
      WBInteraction000001410
      WBInteraction000002110
      WBInteraction000002111
      WBInteraction000002113
      WBInteraction000002114
      WBInteraction000002115
      WBInteraction000002472
      WBInteraction000002533
      WBInteraction000003081
      WBInteraction000003087
      WBInteraction000003096
      WBInteraction000003113
      WBInteraction000003121
      WBInteraction000003122
      WBInteraction000003133
      WBInteraction000003140
      WBInteraction000003141
      WBInteraction000003161
      WBInteraction000003162
      WBInteraction000003171
      WBInteraction000003172
      WBInteraction000003176
      WBInteraction000003181
      WBInteraction000003217
      WBInteraction000003241
      WBInteraction000003273
      WBInteraction000003274
      WBInteraction000003285
      WBInteraction000003286
      WBInteraction000003297
      WBInteraction000003316
      WBInteraction000003317
      WBInteraction000003329
      WBInteraction000003330
      WBInteraction000003338
      WBInteraction000003381
      WBInteraction000003423
      WBInteraction000003425
      WBInteraction000003429
      WBInteraction000003430
      WBInteraction000003432
      WBInteraction000003433
      WBInteraction000003434
      WBInteraction000003442
      WBInteraction000003452
      WBInteraction000003453
      WBInteraction000003492
      WBInteraction000003493
      WBInteraction000003524
      WBInteraction000003525
      WBInteraction000003546
      WBInteraction000003627
      WBInteraction000003648
      WBInteraction000003703
      WBInteraction000003732
      WBInteraction000003733
      WBInteraction000003738
      WBInteraction000003739
      WBInteraction000003740
      WBInteraction000003762
      WBInteraction000003763
      WBInteraction000003764
      WBInteraction000003782
      WBInteraction000003827
      WBInteraction000003828
      WBInteraction000003853
      WBInteraction000003924
      WBInteraction000003925
      WBInteraction000003964
      WBInteraction000003965
      WBInteraction000003975
      WBInteraction000003976
      WBInteraction000003995
      WBInteraction000004002
      WBInteraction000004003
      WBInteraction000004066
      WBInteraction000004067
      WBInteraction000004068
      WBInteraction000004077
      WBInteraction000004078
      WBInteraction000004097
      WBInteraction000004098
      WBInteraction000004101
      WBInteraction000004110
      WBInteraction000004113
      WBInteraction000005059
      WBInteraction000005060
      WBInteraction000005061
      WBInteraction000005095
      WBInteraction000005709
      WBInteraction000005710
      WBInteraction000005711
      WBInteraction000005712
      WBInteraction000005713
      WBInteraction000005714
      WBInteraction000005715
      WBInteraction000005716
      WBInteraction000005719
      WBInteraction000005720
      WBInteraction000005721
      WBInteraction000009829
      WBInteraction000029218
      WBInteraction000029219
      WBInteraction000029284
      WBInteraction000029751
      WBInteraction000029765
      WBInteraction000029776
      WBInteraction000029781
      WBInteraction000029907
      WBInteraction000030145
      WBInteraction000031025
      WBInteraction000031061
      WBInteraction000031062
      WBInteraction000031063
      WBInteraction000031064
      WBInteraction000052731
      WBInteraction000052732
      WBInteraction000052862
      WBInteraction000501659
      WBInteraction000501674
      WBInteraction000501894
      WBInteraction000502199
      WBInteraction000502200
      WBInteraction000502235
      WBInteraction000502727
      WBInteraction000503772
      WBInteraction000504426
      WBInteraction000504445
      WBInteraction000504446
      WBInteraction000504651
      WBInteraction000504890
      WBInteraction000504891
      WBInteraction000518629
      WBInteraction000518746
      WBInteraction000518747
      WBInteraction000520122
      WBInteraction000520754
      WBInteraction000520756
      WBInteraction000520758
      WBInteraction000520827
      WBInteraction000520828
      WBInteraction000523994
      WBInteraction000524191
      WBInteraction000524192
      WBInteraction000525154
      WBInteraction000525158
      WBInteraction000541192
      WBInteraction000541194
      WBInteraction000542163
      WBInteraction000542496
    WBProcess: WBbiopr:00000031
      WBbiopr:00000057
      WBbiopr:00000081
      WBbiopr:00000083
  Map_info: Map: II Position: -0.85522 Error: 0.001406
    Well_ordered
    Positive: Inside_rearr: arDp2
      Positive_clone: C02B6
        F59G1 Inferred_automatically: From sequence, transcript, pseudogene data
    Negative: Outside_rearr: ccDf5
    Mapping_data: 2_point: 40
        777
        4220
      Multi_point (15)
      Pos_neg_data: 3708
        4223
        4224
        5921
        9121
        10365
    Landmark_gene
  Reference (400)
  Remark: Rfam accession number: MI0000002
  Method: Gene